2014 Sleep Regulation and Function Gordon Research Conference

2014年睡眠调节与功能戈登研究会议

• 批准号: 8824984
• 负责人: MARK R OPP
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8824984
• 关键词: Alzheimer' s Disease; Area; Assimilations; Astrocytes; Automobile Driving; Biological Clocks; Biological Models; Biological Neural Networks; Brain; Circadian Rhythms; Communities; Complement; Complex; Data; Discipline; Disease; Dissection; Elements; Genetic; Health; Huntington Disease; In Vitro; Invertebrates; Lead; Link; Malignant Neoplasms; Mammals; Methodology; Methods; Molecular Biology; Molecular Genetics; Neurobiology; Neurons; Neurosciences; Oral; Organism; Parkinson Disease; Pathway interactions; Phenotype; Process; Property; Regulation; Research; Research Personnel; Rest; Role; Science; Scientist; Sleep; Sleep Disorders; Structure; Synapses; Systems Biology; Techniques; Time; Training; Wakefulness; Whole Organism; Work; abstracting; base; career; fly; in vivo; innovation; insight; mathematical model; meetings; neurobiological mechanism; next generation; posters; programs; relating to nervous system; sleep regulation; symposium; symptom management; theories; tool; trend

DESCRIPTION (provided by applicant): Sleep Regulation and Function 2014: The inaugural Gordon Research Conference on "Sleep Regulation and Function" will be held in 2014. The focus of this conference is "Emerging Themes and Paradigm Shifts". During the past two decades we have witnessed a paradigm shift in the conceptualization of how sleep is regulated. In contrast to the traditional view that the brain imposes sleep on the organism, this new paradigm views sleep as a homeostatically regulated, use-dependent process that first emerges at the level of simple neuronal networks. At this level, activity and rest alternate both in neural networks and in invertebrates. In more complex organisms, the alternation between sleep and wakefulness is regulated by neural structures and neuromodulatory pathways that orchestrate and synchronize local sleep processes. The hypothesis that sleep is a local-use dependent process is now reflected in research programs ranging from synaptic scaling and plasticity to oscillating networks in vitro. The importance of gliotransmission and neural-glial interactions for normal brain function and for the regulation of sleep is an emerging theme within the field. Newly characterized sleep phenotypes under conditions of impaired gliotransmission suggest that astrocytes do much more than simply provide support for neurons. Within the context of paradigm shifts and emerging themes, a research program has emerged in which investigators from many different backgrounds ask basic questions about the regulation and function of sleep at a local level as well as at the level of the whole organism. Investigators use a wide range of methodologies developed within the disciplines of molecular biology, genetics, systems biology, neuroscience, mathematical modeling and others. Although the aforementioned paradigm shift and emerging theme will be highlights of the conference, their relatedness to other topics of sleep research will be emphasized in sessions on model systems; the genetics of sleep; and molecular-genetic dissection of complex networks. The objectives of the conference are to; bring together scientists from within and outside the sleep research community who will contribute to a highly integrated conference; provide a forum for discussion of the latest research in the field; and contribute to the training of the next generation of sleep researchers.

描述（由申请人提供）：睡眠调节和功能2014年：首届戈登研究会议“睡眠调节和功能”将在2014年举行。本次会议的重点是“新兴主题和范式转变”。在过去的二十年里，我们目睹了睡眠如何调节的概念化的范式转变。与传统的认为睡眠是大脑强加给生物体的观点相反，这种新的范式将睡眠视为一种自我平衡调节的、依赖于使用的过程，这种过程首先出现在简单的神经元网络水平上。在这个水平上，活动和休息在神经系统中交替进行 网络和无脊椎动物。在更复杂的生物体中，睡眠和清醒之间的交替是由神经结构和神经调节通路调节的，这些神经结构和神经调节通路协调和同步局部睡眠过程。睡眠是一个局部使用依赖性过程的假设现在反映在从突触缩放和可塑性到体外振荡网络的研究计划中。神经胶质传递和神经胶质相互作用对于 正常的脑功能和睡眠调节是该领域的新兴主题。在神经胶质传递受损的情况下，新的特征性睡眠表型表明星形胶质细胞不仅仅是简单地为神经元提供支持。在范式转变和新兴主题的背景下，出现了一个研究计划，来自许多不同背景的研究人员在局部水平以及整个生物体水平上询问有关睡眠调节和功能的基本问题。研究人员使用分子生物学，遗传学，系统生物学，神经科学，数学建模等学科内开发的各种方法。虽然上述范式转变和新出现的主题将是会议的亮点，但它们与睡眠研究其他主题的相关性将在模型系统、睡眠遗传学和复杂网络的分子遗传学解剖等会议中得到强调。会议的目标是：汇集睡眠研究界内外的科学家，他们将为一个高度综合的会议做出贡献;提供一个讨论该领域最新研究的论坛;并为下一代睡眠研究人员的培训做出贡献。