2014 Sleep Regulation and Function Gordon Research Conference

2014年睡眠调节与功能戈登研究会议

• 批准号: 8646096
• 负责人: MARK R OPP
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8646096
• 关键词: Alzheimer' s Disease; Area; Assimilations; Astrocytes; Automobile Driving; Biological Clocks; Biological Models; Biological Neural Networks; Brain; Circadian Rhythms; Communities; Complement; Complex; Data; Discipline; Disease; Dissection; Elements; Genetic; Huntington Disease; In Vitro; Invertebrates; Lead; Link; Malignant Neoplasms; Mammals; Methodology; Methods; Molecular Biology; Molecular Genetics; Neurobiology; Neurons; Neurosciences; Oral; Organism; Parkinson Disease; Pathway interactions; Phenotype; Process; Property; Regulation; Research; Research Personnel; Rest; Role; Science; Scientist; Sleep; Sleep Disorders; Structure; Synapses; Systems Biology; Techniques; Time; Training; Wakefulness; Whole Organism; Work; abstracting; base; career; fly; in vivo; innovation; insight; mathematical model; meetings; neurobiological mechanism; next generation; posters; programs; public health relevance; relating to nervous system; sleep regulation; symposium; symptom management; theories; tool; trend

DESCRIPTION (provided by applicant): Sleep Regulation and Function 2014: The inaugural Gordon Research Conference on "Sleep Regulation and Function" will be held in 2014. The focus of this conference is "Emerging Themes and Paradigm Shifts". During the past two decades we have witnessed a paradigm shift in the conceptualization of how sleep is regulated. In contrast to the traditional view that the brain imposes sleep on the organism, this new paradigm views sleep as a homeostatically regulated, use-dependent process that first emerges at the level of simple neuronal networks. At this level, activity and rest alternate both in neural networks and in invertebrates. In more complex organisms, the alternation between sleep and wakefulness is regulated by neural structures and neuromodulatory pathways that orchestrate and synchronize local sleep processes. The hypothesis that sleep is a local-use dependent process is now reflected in research programs ranging from synaptic scaling and plasticity to oscillating networks in vitro. The importance of gliotransmission and neural-glial interactions for normal brain function and for the regulation of sleep is an emerging theme within the field. Newly characterized sleep phenotypes under conditions of impaired gliotransmission suggest that astrocytes do much more than simply provide support for neurons. Within the context of paradigm shifts and emerging themes, a research program has emerged in which investigators from many different backgrounds ask basic questions about the regulation and function of sleep at a local level as well as at the level of the whole organism. Investigators use a wide range of methodologies developed within the disciplines of molecular biology, genetics, systems biology, neuroscience, mathematical modeling and others. Although the aforementioned paradigm shift and emerging theme will be highlights of the conference, their relatedness to other topics of sleep research will be emphasized in sessions on model systems; the genetics of sleep; and molecular-genetic dissection of complex networks. The objectives of the conference are to; bring together scientists from within and outside the sleep research community who will contribute to a highly integrated conference; provide a forum for discussion of the latest research in the field; and contribute to the training of the next generation of sleep researchers.

描述（申请人提供）：睡眠调节与功能2014：首届“睡眠调节与功能”戈登研究会议将于2014年举行。本次会议的重点是“新兴主题和范式转变”。在过去的二十年里，我们目睹了睡眠是如何被调节的概念的范式转变。与大脑将睡眠强加于有机体的传统观点相反，这种新范式认为睡眠是一个自我调节的、依赖于使用的过程，首先出现在简单的神经网络层面。在这个层次上，活动和休息交替进行