Race, Childhood Social Disadvantage, and the Adult Brain: HANDLS BRAINCHILD.

种族、童年社会弱势和成人大脑：HANDLS BRAINCHILD。

• 批准号: 8766303
• 负责人: Danielle Lathel Beatty Moody
• 金额: $ 12.3万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8766303
• 关键词: Accounting; Address; Adolescent; Adult; African American; Age; Aging; Alcohol or Other Drugs use; Ancillary Study; Anger; Anisotropy; Back; Baltimore; Behavioral; Blood Pressure; Body mass index; Brain; Brain Diseases; Brain Pathology; Build-it; C-reactive protein; Cerebrovascular Disorders; Childhood; Cholesterol; Clinical; Cognitive; Cognitive aging; Coronary heart disease; Data; Dementia; Development; Development Plans; Diet; Diffusion; Diffusion Magnetic Resonance Imaging; Disadvantaged; Discrimination; Disease; Distal; Education; Elderly; Employee Strikes; Environment; Epidemiology; Exposure to; Future; Glucose; Goals; Health; Hostility; Impaired cognition; Insulin; Intervention; Intramural Research Program; Investigation; Legal; Lesion; Life; Life Cycle Stages; Link; Literature; Longevity; Magnetic Resonance Imaging; Maryland; Measures; Mediator of activation protein; Mentored Research Scientist Development Award; Minority; Morbidity - disease rate; National Institute on Aging; Neighborhoods; Occupational; Outcome; Participant; Pathway interactions; Physical Function; Physical activity; Precipitating Factors; Prevalence; Prevention strategy; Preventive Intervention; Process; Protocols documentation; Psychosocial Factor; Race; Race Relations; Research; Resources; Risk; Risk Factors; Role; Socioeconomic Status; Stress; Stroke; Training; age related; aging brain; arm; career; career development; cerebrovascular; depressive symptoms; early onset; experience; functional decline; functional outcomes; gray matter; health disparity; healthy aging; heart disease risk; indexing; low socioeconomic status; middle age; mortality; prevent; programs; psychosocial; public health relevance; response; social; theories; vigilance; white matter

DESCRIPTION (provided by applicant): The objective of the proposed career development plan is to launch the candidate's independent research career investigating the mechanisms by which racial disparities in exposure to early life social disadvantage (ELSD) promote accelerated subclinical and clinical brain pathology in African Americans (AA) across the life course. There are pronounced AA-White disparities in brain health endpoints including stroke, dementia, and cognitive decline. Recent data suggest that earlier disparities in brain health are also noted on magnetic resonance imaging (MRI). Exposure to greater ELSD - characterized by harsher residential and neighborhood environments and lower parental socioeconomic status (SES) - may chart a course towards an accelerated onset of and more severe brain pathology observed in AAs as characterized by multiple MRI-assessed indicators of subclinical brain pathology including lower gray matter (GM) volumes, greater white matter lesion volumes and lesser WM integrity. This application was originally submitted in response to the NIA K01 PAR- 09-136, "Promoting Careers in Aging and Health Disparities Research" that sought to delineate social factors that precipitate late life health disparities among minorities and elders from disadvantaged backgrounds. Due to discontinuation of that PAR, the current application is a resubmission to the NIA K01 PA-11-190, Mentored Research Scientist Development Award. This K01 will allow the candidate to extend her prior training on the relation of psychosocial factors to coronary heart disease risk among adolescent and early to midlife AAs by providing training in (1) the life course perspective and accelerated theories of aging, particularly as applied to racial disparities in social disadvantage and health, and (2) the brain and related vasculature, and MRI- indicators of brain pathology including subclinical cerebrovascular disease. The proposed project will be a substudy to the ongoing HANDLS SCAN project - itself an ancillary study to the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) study, a 20-year epidemiological investigation conducted by the NIA Intramural Research Program that assesses health disparities in > 3,500 AA and White adults (ages 30-64 at baseline) living in Baltimore, MD. In up to 400 HANDLS participants, HANDLS SCAN examines the relations of race and adult SES to MRI-indicators of brain pathology that may underlie risk for stroke, dementia, and cognitive and functional decline. In the proposed study, 300 HANDLS SCAN participants will complete measures of ELSD to determine: (1) whether ELSD is related to MRI-indicators of brain pathology predictive of future stroke, cognitive, and functional decline, and whether these associations are more pronounced in AAs than in White adults, and (2) explore potential psychosocial, behavioral, and biomedical mediators of these associations. The interdisciplinary training outlined in this application will allow the candidate o carve out a unique and unmatched research program that is desperately warranted by the pronounced prevalence of cerebrovascular and other brain disease in AAs. The interrelations among life course social disadvantage, accelerated aging, and brain health endpoints have been grossly understudied and are crucial to developing appropriate prevention and intervention strategies geared toward reducing and ultimately eliminating race-related health disparities in brain aging.

描述（由申请人提供）：拟议的职业发展计划的目的是启动候选人的独立研究职业，调查了暴露于早期生活社会劣势（ELSD）中的种族差异（ELSD）在整个生活过程中促进非洲美国人（AA）的加速亚临床和临床脑病理学的机制。大脑健康终点（包括中风，痴呆和认知能力下降）中有明显的AA-White差异。最近的数据表明，在磁共振成像（MRI）上还指出了脑部健康方面的早期差异。暴露于更大的ELSD（以更苛刻的住宅和邻里环境以及较低的父母社会经济地位（SES）为特征）可能会绘制在AAS中观察到的加速和更严重的脑病理学的课程，其特征是多种MRI -MIRI评估的亚细脑病理学指标，包括较低的灰色物质（包括较低的灰色物质（GM）沃姆斯，较大的白色物质，更差的白色物质和较差的白色物质和差异。该申请最初是针对NIA K01 PAR-09-136提交的，“促进衰老和健康差异研究的职业”，该研究旨在描绘社会因素，这些因素会导致少数群体和长者之间在弱势背景中造成后期生活健康差异。由于中止该标准杆，当前的应用程序是对NIA K01 PA-11-11-190的重新提交，这是研究科学家发展奖。该K01将允许候选人通过在（1）（1）（1）生活课程的观点和加速衰老理论的培训中培训在青少年和中年AA的冠状动脉疾病风险上的先前培训，尤其是在社会障碍和关系中的培训，尤其是在社会障碍和健康方面应用的，以及MR脑血管疾病。拟议的项目将是正在进行的Handls扫描项目的一个体系 - 本身是一项辅助研究，对整个生命周期多样性的健康衰老研究（Handls）研究（Handls）研究，这是一项由NIA内壁内研究计划进行的20年流行病学研究，可评估> 3,500 AA和白人成人（AA和白人成人30-6-64-64 baltim in Baltim in Baltim in Mase），评估了> 3,500 AA和白人成人的健康状况。在多达400名Handls参与者中，Handls扫描检查了种族和成人SES与脑病理学的MRI指导者的关系，这些关系可能是中风，痴呆症以及认知和功能下降的风险。在拟议的研究中，300个Handls扫描参与者将完成ELSD的措施，以确定：（1）ELSD是否与脑病理学的MRI鉴定剂相关，可预测未来中风，认知和功能下降的脑病理学，以及这些关联在AAS中是否比白人成人和（2）探索潜在的心理社会式化合物在AAS中更为明显。本应用程序中概述的跨学科培训将使候选人o制定一项独特而无与伦比的研究计划，该计划被AAS中脑血管和其他脑部疾病的明显流行迫切保证。生活过程之间的相互关系社会劣势，加速衰老和大脑健康终点已严格研究，对于制定适合减少和最终消除与种族相关的健康差异的适当预防和干预策略至关重要。