(Basic Shared Resources) Analytical Biochemistry

（基础共享资源）分析生物化学

• 批准号: 8633118
• 负责人: Douglas Yee
• 金额: $ 10.85万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8633118
• 关键词: 1,3-Butadiene; 2-butenal; Acetylcysteine; Acrolein; Analytical Biochemistry; Analytical Chemistry; Aromatic Polycyclic Hydrocarbons; Benzene; Biological Markers; Butanones; Cancer Center; Cancer Center Support Grant; Carcinogens; Cardiovascular system; Chemoprevention; Chromatography; Consult; Contract Services; Coupled; DNA Adducts; Doctor of Philosophy; Equipment; Ethylene Oxide; Etiology; Funding; Gas Chromatography; Glucuronides; Head; High Pressure Liquid Chromatography; Human Resources; Liquid Chromatography; Maintenance; Malignant Neoplasms; Mass Spectrum Analysis; Mission; N' -nitrosonornicotine; Nature; Nicotine; Nitrosamines; Nucleic Acids; Nucleosides; Oligonucleotides; Organic Chemistry; Peptides; Plasma; Prevention; Proteins; Proteomics; Research; Research Activity; Research Personnel; Resource Sharing; Resources; Scientist; Services; Site; Techniques; Tobacco; Tobacco-Associated Carcinogen; Universities; Urine; carcinogenesis; cost; cost effective; design; experience; instrument; instrumentation; mass spectrometer; member; method development; operation; programs; repaired; small molecule; toxicant; urinary

The mission ofthe Analytical Biochemistry Shared Resource is to provide high-quality analytical services to members ofthe Masonic Cancer Center (MCC) by providing state-of-the-art chromatographic, mass spectrometric, and related techniques, in a timely and cost-efficient manner. The Resource provides ¿ mass spectrometry services ¿ analytical biochemistry services, emphasizing tobacco carcinogen and toxicant biomarker analyses ¿ chromatography services: on-site consulting for the maintenance and service of high-performance liquid chromatography and gas chromatography equipment Stephen Hecht, PhD, the director of Analytical Biochemistry, has many years of experience in analytical organic chemistry and mass spectrometry. Four other staff members also bring decades of experience with mass spectrometry (Dr. Peter Villalta and Brock Matter), nicotine metabolites (Dr. Sharon Murphy), and chromatography (Steven Carmelia). Analytical Biochemistry remains an outstanding and extensively used resource that serves members of almost all ofthe MCC Programs as well as other researchers at the University. The specialized nature of the facility enables services to be provided at very cost-effective rates, while providing users access to equipment in a timely manner. Most instruments are maintained and repaired by Resource staff, avoiding the need for costly service contracts. Members ofthe MCC rely on Analytical Biochemistry staff for guidance on related projects, method development, and troubleshooting of instruments. This heavily used and technically outstanding facility continues to provide crucial services to its highly productive users.

分析生物化学共享资源的使命是通过提供最先进的色谱，质谱和相关技术，及时和经济高效地为共济会癌症中心（MCC）的成员提供高质量的分析服务。资源提供质谱服务分析生物化学服务，强调烟草致癌物和有毒生物标志物分析色谱服务：高效液相色谱和气相色谱设备的维护和服务现场咨询Stephen Hecht博士，分析生物化学主任，在分析有机化学和质谱方面拥有多年的经验。另外四名工作人员也带来了数十年的质谱（Peter Villalta博士和Brock Matter）、尼古丁代谢物（Sharon Murphy博士）和色谱（Steven Carmelia）方面的经验。分析生物化学仍然是一个杰出的和广泛使用的资源，服务于几乎所有MCC项目的成员以及大学的其他研究人员。该设施的专门性质使其能够以极具成本效益的费率提供服务，同时使用户能够及时使用设备。大多数仪器由资源部门的工作人员维护和修理，避免了签订昂贵的服务合同的需要。MCC的成员依靠分析生物化学工作人员在相关项目、方法开发和仪器故障排除方面的指导。这个大量使用和技术出色的设施继续为其高生产力用户提供关键服务。