Development of Shared Resources

7.5.4.1说明和任务 有几种方法可以优化新的癌症治疗方法。药物调度与药代动力学 问题显然与结果有关。例如，剂量密集型计划在乳房治疗中提供了优越的结果 癌症辅助治疗。药物代谢和药物水平不足，如他莫昔芬所建议的那样， 也可能对结果产生不利影响。 了解和确定抗癌药物治疗反应的变异性来源是一个 对临床研究人员提出了重大挑战。可变性的来源可能不明显，因此， 需要一些技术来帮助识别、解释和评估可变性，以确保正确解释 临床试验结果。发展中的临床药理共享资源将为肿瘤中心提供 成员： ？提供咨询服务，协助设计、实施和数据解释药动学， 药效学和药理学研究* ？为研究样本的药物分析和药物定量的开发提供分析服务， ？样品采集服务，协助获取、处理和储存本地和 多中心药理学研究。

7.5.4.1 DESCRIPTION AND MISSION There are several ways that new cancer therapeutics can be optimized. Drug scheduling and pharmacokinetic issues clearly relate to outcome. For example* dose-dense scheduling provides superior outcomes in breast cancer adjuvant therapy. Drug metabolism and inadequate drug levels, as has been suggested for tamoxifen, may also adversely affect outcome. Understanding and identifying sources of variability in responsiveness to anti-cancer drug therapy is a significant challenge to clinical investigators. The source of variability may not be obvious and thus, techniques to help identify, explain and evaluate the variability are needed to assure proper interpretation of clinical trial results. The developing Clihical Pharmacology Shared Resource will provide to Cancer Center members: ¿ consultion services to assist in the design, conduct and data interpretation of pharmacokinetic, pharmacodynamic and pharmacogenetjc studies* ¿ analytical services for development of drug assays and drug quantification of study specimens, ¿ sample acquisition services to assist in obtaining, processing and storage of samples for local and multi-center pharmacology studies.