Implementation of an Elementary and Robust Implantable Sensor for Musculoskeletal

用于肌肉骨骼的基本且稳健的植入式传感器的实现

• 批准号: 8511155
• 负责人: ERIC H LEDET
• 金额: $ 16.42万
• 依托单位: RENSSELAER POLYTECHNIC INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8511155
• 关键词: Activities of Daily Living; Animal Model; Arthrodesis; Back; Biomechanics; Caliber; Caregivers; Caring; Cervical; Cervical spine; Clinical; Clinical Research; Custom; Data; Diagnosis; Diagnostic; Economic Burden; Electronics; Fracture Healing; Frequencies; Goat; Harvest; Healed; Health; Histology; Housing; Implant; Individual; Insula of Reil; Intervertebral disc structure; Joints; Life; Link; Measures; Medical; Medicine; Modification; Motion; Muscle; Musculoskeletal; Musculoskeletal Diseases; Orthopedics; Outcome; Patient Care; Patients; Pattern; Performance; Physical environment; Posture; Reading; Recurrence; Rehabilitation therapy; Reporting; Research; Saline; Sampling; Spinal; Spinal Fusion; Spinal Injuries; System; Technology; Telemetry; Temperature; Testing; Thick; Time; Tissues; Treatment Protocols; United States; Vertebral column; Wireless Technology; Work; base; biomaterial compatibility; burden of illness; clinical application; clinical practice; clinically relevant; cost; healing; improved; in vivo; in vivo Model; instrument; meetings; novel; outcome forecast; pre-clinical; pressure; public health relevance; response; sensor; time use; tool

DESCRIPTION (provided by applicant): The clinical utility of smart implants to facilitate personalized medicine in musculoskeletal disease is vast. On a patient-specific basis, the implant's physical environment provides a wealth of diagnostic data regarding the progression of healing and prognosis of an outcome. Customized care through personalized medicine reduces costs and improves outcomes by facilitating better diagnoses and optimal treatment regimens for individual patients. Previous smart implant systems used for research have not been adaptable to daily clinical practice due to complexity, cost, and the required modification of host implants. In this project, we will develop and implement a simple, robust, inexpensive, battery-less, telemetry-less, single component implantable sensor with no electrical connections for musculoskeletal smart implants. We will demonstrate that the sensor meets the criteria to facilitate personalized musculoskeletal medicine in daily clinical practice. The sensors will be integrated into spinal implants to (a) objectively correlate in vivo force to progress of spinal fusion, and (b) quantify real time in vivo multi-axial interbody force (axial and shear) during dynamic activities in the goat cervical spine.

描述（由申请人提供）：智能植入物在促进肌肉骨骼疾病个性化治疗方面的临床效用是巨大的。在患者特定的基础上，植入物的物理环境提供了大量关于愈合进展和预后结果的诊断数据。通过个性化医疗提供定制化护理，为个体患者提供更好的诊断和最佳治疗方案，从而降低成本并改善结果。先前用于研究的智能植入物系统由于复杂性、成本和所需的修改而不适用于日常临床实践。 宿主植入物在这个项目中，我们将开发和实现一种简单，坚固，廉价，无电池，无遥测，单组件植入式传感器，没有肌肉骨骼智能植入物的电气连接。我们将证明传感器符合标准，以促进个性化的肌肉骨骼医学在日常临床实践中。传感器将集成到脊柱植入物中，以（a）客观地将体内力与脊柱融合的进展相关联，以及（B）量化山羊颈椎动态活动期间的真实的体内多轴椎间力（轴向和剪切力）。