Stress-Evoked Muscle Activity in Occupational Myalgia

职业性肌痛中压力诱发的肌肉活动

• 批准号: 8497419
• 负责人: Katrina S. Monroe
• 金额: $ 17.98万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2014-08-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8497419
• 关键词: Address; Advisory Committees; Age; Anxiety; Biomechanics; Case-Control Studies; Chronic; Chronic neck pain; Clinical; Clinical Trials; Controlled Study; Developed Countries; Development; Diagnostic; Disease; Eligibility Determination; Employment; Epidemiologic Studies; Exhibits; Future; Goals; Health; Individual; Intervention; Joints; Modeling; Muscle; Musculoskeletal Diseases; Musculoskeletal Pain; Myalgia; Neck Pain; Occupational; Occupations; Pain; Patients; Play; Population; Prevalence; Prevention; Prevention strategy; Prospective Studies; Protocols documentation; Psychosocial Factor; Psychosocial Stress; Research; Research Design; Research Priority; Risk; Risk Factors; Role; Sensory; Stress; Subgroup; Testing; Work; Workload; Workplace; bone; chronic pain; clinical decision-making; design; diagnostic accuracy; effective therapy; high risk; improved; modifiable risk; multidisciplinary; prevent; psychosocial; response; screening; sex; stress management; tool; trait; trapezius muscle; treatment strategy

DESCRIPTION (provided by applicant): The increasing prevalence of musculoskeletal disorders in the workplace has been identified as one of the most costly health concerns faced by industrialized nations. Epidemiologic studies suggest that both physical and psychosocial factors play a critical role in the development of work-related neck pain, yet interactions among these risk factors remain poorly understood. The underlying cause of chronic neck pain remains undiagnosed for the majority of cases, likely resulting in suboptimal treatment for many individual patients. The overall goal of this project is to assess the validity of a new screening protocol to identify stress-evoked muscle activity that may either cause or exacerbate neck pain in susceptible individuals. Aim 1 will use a case- control study design to assess the discriminant and concurrent validity of a standardized screening protocol to detect elevated psychomotor responses to stress in subjects with and without chronic neck pain. Aim 2 will use a prospective study design to determine the predictive validity of this screening protocol by assessing the risk of developing chronic neck pain in asymptomatic office workers during the first year of employment in a high-risk occupation. This aim will also determine the diagnostic cutoff score for stress-evoked muscle activity that best predicts the future development of chronic neck pain. Findings from this project will inform the design of future clinical trials by providing a validated tool to identify subgroups of individuals that are most likely to benefit from stress-management interventions to prevent or treat chronic neck pain, which will ultimately improve clinical decision-making for practitioners who treat this disorder. This project will also provide new information on modifiable physical and psychosocial risk factors for chronic neck pain, consistent with research priorities outlined by a multidisciplinary task force of experts in the field.

描述（由申请人提供）：工作场所肌肉骨骼疾病的日益普遍已被确定为工业化国家面临的最昂贵的健康问题之一。流行病学研究表明，身体和心理社会因素在工作相关颈部疼痛的发展中起着关键作用，但这些危险因素之间的相互作用仍然知之甚少。慢性颈部疼痛的根本原因在大多数病例中仍未得到诊断，这可能导致许多个体患者的治疗效果不佳。该项目的总体目标是评估一种新的筛查方案的有效性，以确定可能导致或加剧易感个体颈部疼痛的应激诱发肌肉活动。目标1将使用病例对照研究设计来评估标准化筛选方案的判别和并行有效性，以检测患有和不患有慢性颈痛的受试者对压力的心理反应升高。目标2将采用前瞻性研究设计，通过评估无症状办公室工作人员在高风险职业中就业的第一年内发生慢性颈部疼痛的风险，来确定该筛查方案的预测有效性。这一目标还将确定最能预测慢性颈痛未来发展的应激诱发肌肉活动的诊断临界评分。该项目的研究结果将通过提供一种经过验证的工具来确定最有可能从压力管理干预措施中受益的个体亚组，从而为未来的临床试验设计提供信息，以预防或治疗慢性颈部疼痛，这将最终改善治疗这种疾病的从业者的临床决策。该项目还将提供关于慢性颈部疼痛的可改变的身体和心理社会风险因素的新信息，与该领域多学科专家工作队概述的研究优先事项一致。