Molecular mechanisms for copper trafficking across membranes.

铜跨膜运输的分子机制。

• 批准号: DP140102746
• 负责人: Prof Megan Maher
• 金额: $ 23.28万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102746
• 关键词: Molecular; mechanisms; copper; trafficking; across

Copper is a trace metal that is essential for all forms of life, however it is toxic in excess. Tightly controlled protein-based metalloregulatory systems are responsible for copper uptake and homeostasis in all cells. Components of these systems are integral membrane transport proteins, which include the Ctr proteins that are solely responsible for copper uptake into eukaryotic cells. This project aims to define the molecular mechanisms by which the Ctr proteins transport copper across eukaryotic cell membranes, by solving their three-dimensional structures by X-ray crystallography.

铜是一种微量金属，对所有形式的生命都是必不可少的，但过量则有毒。严格控制的蛋白质为基础的金属调节系统负责铜的吸收和稳态在所有的细胞。这些系统的组分是整合的膜转运蛋白，其包括Ctr蛋白，其仅负责铜摄取到真核细胞中。该项目旨在通过X射线晶体学解决其三维结构来确定Ctr蛋白跨真核细胞膜运输铜的分子机制。