Renal Sympathetic Denervation in Congestive Heart Failure
充血性心力衰竭中的肾交感神经去神经支配
基本信息
- 批准号:8588995
- 负责人:
- 金额:$ 36.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAcuteAreaCardiacCardiovascular DiseasesCathetersClinicClinicalClinical ResearchClinical SciencesClinical TrialsCollaborationsCommunity HospitalsCongestive Heart FailureDevelopmentDiagnosisEnrollmentEnvironmentEvaluationFunctional disorderGoalsHeart failureHypertensionIncidenceInstitutionInstitutional Review BoardsInstructionInvestigationJointsKidneyLeadLeadershipMeasurementMediatingMedical centerNatriuresisNatriuretic PeptidesNerveOutcomeParticipantPatientsPerformancePhaseProcessProductionProspective StudiesRandomized Clinical TrialsRecruitment ActivityRefractoryRenal functionResearchResearch InfrastructureResearch PersonnelResearch SubjectsRoleSafetySympathectomySymptomsSyndromeSystemTechniquesTestingTherapeuticTranslational ResearchTubular formationUniversitiesUniversity Hospitalsaging populationbasedesignexperiencehemodynamicsimprovedinterestmedical schoolsmeetingsnovelnovel strategiesnovel therapeuticsoutreachpatient populationtooltreatment as usual
项目摘要
This proposal represents a joint effort combining the vast infrastructure, extensive clinical and research
experience, as well as large patient volumes in heart failure at the Cleveland Clinic, together with the clinical
trial expertise and diverse patient populations at University Hospitals and MetroHealth Medical Center to
establish the Cleveland Regional Clinical Center (RCC). Led by Drs. W. H. Wilson Tang and Randall C.
Starting and joined by Drs. James Fang and Mark Dunlap as co-investigators, and taking advantage of the
Cleveland Clinical and Translational Sciences Collaborative (CTSC) that recently integrated the research
infrastructure our three institutions, our goal is to participate in the Heart Failure Clinical Research Network
to test new hypotheses and therapies to advance the management of heart failure. In particular, we hope to
expand our longstanding academic interest in developing strategies to alleviate cardio-renal compromise in
congestive heart failure. Our proposed project serves as a mechanistic study to discern the possible role of
renal sympathetic nerves in mediating cardiac and/or renal complications of the cardio-renal syndrome.
Utilizing a novel, catheter-based renal sympathetic denervation (RSD) technique currently under
investigation for treatment of refractory hypertension (Symplicity Catheter System), we test the hypothesis
that in patients with hypertensive heart failure recently admitted for congestive heart failure that RSD may
provide incremental improvement in neurohormonal profile, improve cardio-renal function, and facilitate
symptomatic relief over usual care. Our consortium provides a unique opportunity to contribute to the overall
Network with clinical trials expertise and leadership in heart failure to fulfill the scientific requirements, and
the diverse and broad regional patient populations across a wide range of practice settings with proven
abilities to recruit and fulfill the performance requirements, and to test a novel treatment approach to tackle
one of the most challenging aspects of contemporary heart failure.
这项提案代表了一项联合努力,将庞大的基础设施、广泛的临床和研究
经验,以及克利夫兰诊所心力衰竭的大量患者,以及临床
大学医院和MetroHealth医疗中心的试验专业知识和多样化的患者人群,
克利夫兰地区临床中心(Cleveland Regional Clinical Center,RCC)由W博士领导。H. Wilson Tang和Randall C.
由James Fang博士和Mark Dunlap博士作为共同研究者开始并加入,并利用
克利夫兰临床和转化科学合作组织(CTSC)最近整合了这项研究
我们的三个机构的基础设施,我们的目标是参与心力衰竭临床研究网络
测试新的假设和疗法,以推进心力衰竭的管理。特别是,我们希望
扩大我们长期以来在制定战略,以减轻心肾损害的学术兴趣,
充血性心力衰竭。我们提出的项目作为一个机制研究,以辨别可能的作用,
肾交感神经介导心肾综合征的心脏和/或肾脏并发症。
利用一种新的,基于导管的肾交感神经去神经(RSD)技术,目前正在
研究治疗难治性高血压(Symplicity导管系统),我们测试假设
在最近因充血性心力衰竭入院的高血压心力衰竭患者中,RSD可能
提供神经激素谱的增量改善,改善心肾功能,并促进
症状缓解优于常规护理。我们的联盟提供了一个独特的机会,有助于整体
与心力衰竭的临床试验专业知识和领导能力建立网络,以满足科学要求,
广泛的实践环境中的多样化和广泛的区域患者人群,
招募和满足性能要求的能力,以及测试新的治疗方法来解决
当代心力衰竭最具挑战性的方面之一。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Randall Carson Starling其他文献
Randall Carson Starling的其他文献
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{{ truncateString('Randall Carson Starling', 18)}}的其他基金
Renal Sympathetic Denervation in Congestive Heart Failure
充血性心力衰竭中的肾交感神经去神经支配
- 批准号:
8198004 - 财政年份:2012
- 资助金额:
$ 36.11万 - 项目类别:
Renal Sympathetic Denervation in Congestive Heart Failure
充血性心力衰竭中的肾交感神经去神经支配
- 批准号:
8403727 - 财政年份:2012
- 资助金额:
$ 36.11万 - 项目类别:
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