Training in the Molecular Basis of Skin/Mucosa Parthobiology

描述（由申请人提供）：俄勒冈州健康与科学大学（OHSU）皮肤科系建议继续其“皮肤病理学分子基础培训”计划，目标是培养高素质的博士前和博士后研究人员，从事实验皮肤病学和相关上皮疾病，特别是癌症和炎性疾病的学术事业。具体来说，我们的目标是：1。让学员进一步了解粘膜和皮肤疾病的分子途径，发展和使用推进该领域所需的专业方法，并提供洞察力并最终应用于临床问题; 2，促进我们的导师/学员实验室之间的互动，丰富皮肤病学领域，并增加其范围和对理解和治疗疾病的影响。该计划提供了一个导师的核心，包括来自皮肤病学研究部门和5个基础科学部门的国际公认的教师研究人员，他们通过该计划进行互动和合作，以形成对上皮癌变和炎症性疾病的关注。该培训计划旨在通过以下方式实现这些目标：1）让学员和导师参与讨论，互动/合作，并分享上皮癌变和表面上皮炎性疾病多个领域的想法和方法（通过每月轮换所有受训人员和辅导员参加的受训人员数据介绍、共同辅导，和共享专业资源）和2）通过与临床皮肤科医生和肿瘤科医生的密切互动，使受训者接触到基础科学向临床治疗的转化（通过我们每月的翻译主题论坛和期刊俱乐部与居民和科学家的联合演讲促进）。该项目涵盖了皮肤和粘膜癌发生、稳态、致癌和肿瘤抑制机制（Trim32，Wnt，TGF？1/SMAD、c-Myc、Ras和B-Raf、胰岛素样生长因子、Cox 2、Piasy、p73、抑制性SMAD）以及癌症和炎症性疾病中的细胞因子，并促进共享专门的研究资源，供学员项目使用（皮肤、结肠和头颈部癌症及炎性疾病的上皮靶向基因开关模型;非侵入性光学成像;上皮和免疫群体的专门细胞分离;我们的分子分析资源包含新鲜冷冻保存的人类肿瘤标本和正常粘膜和皮肤对照）。每年任命两名博士前和三名博士后MD，PhD或MD/PhD候选人，根据他们的能力，他们为该领域带来的特殊经验以及他们进行皮肤/粘膜研究的愿望进行强有力的临床转化成分和对癌症和炎症领域的调查皮肤病学的影响潜力。 相关性：该计划研究身体表面器官（皮肤，口腔和肠粘膜）的癌症和炎症性疾病，以了解它们是如何在组织，细胞，分子和生化水平上引起的，并发现新的治疗方法。皮肤是一个很好的模型，因为我们可以看到癌症和炎症性疾病从最早期开始发展，并且很容易看到对新治疗的反应;然而，我们的小组正在开发非侵入性成像，使我们能够看到口腔和肠道疾病，并将病理与成人干细胞，癌症基因表达和炎症促进分子的变化联系起来。这些和相关上皮细胞的癌症构成了人类癌症的大部分，其中最致命的癌症在美国每年影响超过680，000人，其中近300，000人死亡，而仅牛皮癣（一种皮肤炎性疾病）每年影响美国约750万人，

DESCRIPTION (provided by applicant): The Oregon Health & Science University (OHSU) Department of Dermatology proposes continuation of its "Training in the Molecular Basis of Skin Pathobiology" program with objectives to train highly qualified predoctoral and postdoctoral researchers for academic careers in experimental dermatology and related epithelial disorders, in particular cancer and inflammatory disease. Specifically we aim: 1. to engage trainees in furthering an understanding of the molecular pathways that underlie mucosal and skin disease, in evolving and using specialized approaches needed to advance the field, and in providing insight and ultimately application to clinical problems; and 2, to foster interactions among our mentor/trainee laboratories that enrich the dermatology field and increase its scope and impact on understanding and treating disease. The proposed program offers a core of mentors including internationally recognized faculty researchers from the Dermatology research division and 5 basic science departments who through this program interact and collaborate to form a focus on epithelial carcinogenesis and inflammatory disease. The training program is designed to achieve these aims by 1) engaging trainees and mentors in discussion, interaction/collaboration and sharing ideas and approaches in multiple areas of epithelial carcinogenesis and inflammatory disease of surface epithelia (facilitated through monthly rotation of trainee presentations of data attended by all trainees and mentors, co-mentoring, and sharing specialized resources) and 2) exposing trainees to translation of basic science to clinical treatment through close interaction with clinical dermatologists and oncologists (facilitated through our monthly translational topics forum and journal clubs with joint presentations of residents and scientists). This program spans skin and mucosal carcinogenesis, homeostatic, oncogenic and tumor suppressor mechanisms (Trim32, Wnt, TGF¿1/SMAD, c-Myc, Ras and B-Raf, insulin-like growth factors, Cox2, Piasy, p73, inhibitory SMADs), and cytokines in cancer and inflammatory disorders, and fosters sharing of specialized research resources for use in trainee projects (epithelial-targeted gene-switch models of skin, colon, and head and neck cancer and inflammatory disease; non-invasive optical imaging; specialized cell isolation of epithelial and immune populations; and our Molecular Profiling Resource containing freshly cryopreserved human tumor specimens and normal mucosa and skin controls). Two predoctoral and three postdoctoral MD, PhD or MD/PhD candidates are appointed each year, selected for their aptitude, the special experience they bring to the field and their desire to carry out skin/mucosa research with a strong clinical translational component and potential for impact on investigative dermatology in the areas of cancer and inflammation. RELEVANCE: This program studies cancer and inflammatory diseases of surface organs of the body (skin, oral and intestinal mucosa), to understand how they are caused at the tissue, cellular, molecular and biochemical levels, and to discover new treatments. Skin is a good model because we can see cancer and inflammatory diseases develop from their earliest stages and easily see responses to new treatments; however our group is developing non-invasive imaging that allows us to see oral and intestinal disease as well and to connect the pathology with changes in adult stem cells, cancer gene expression and inflammation-promoting molecules at these organ sites. Cancers of these and related epithelia make up the majority of human cancers, the most deadly of these affecting over 680,000 people a year in the US, with nearly 300,000 deaths, while psoriasis alone (a skin inflammatory disease) affects ~ 7.5 million people in the US annually,