Training in the Molecular Basis of Skin/Mucosa Pathobiology

描述（由申请人提供）：OHSU皮肤病学部门提议继续其为期10年的“皮肤/粘膜病理生物学分子基础培训”计划，目的是为学术事业培养高素质的博士前和博士后研究人员，从而更好地理解和治疗皮肤，口腔和肠道癌症。目前，我们的项目是OHSU唯一一个由nci资助的培训项目，我们的项目专注于癌症的早期阶段，因此是了解多步骤癌变，测试预防策略，瞄准和监测治疗成功的理想选择。具体来说，我们的目标是：1。使学员进一步了解皮肤/粘膜疾病的分子途径，发展和使用专门的方法来推进该领域，并为临床问题提供见解和最终应用。促进导师/实习生实验室之间的互动，丰富皮肤病学领域，扩大其范围和影响，以了解和治疗癌症和炎症性疾病。该项目提供来自皮肤科，6个基础科学部门和5个OHSU研究所和中心的国际公认的教师研究人员，他们致力于培养下一代，并合作形成癌症和炎症疾病的致癌，诊断，预防和治疗的重点。该项目吸引学员和导师分享想法和专业资源(角质细胞和黑素细胞靶向皮肤诱导遗传模型，结肠癌、头颈癌和炎症性疾病、非侵入性光学成像、上皮和免疫群体的专门细胞分离、包含新鲜冷冻保存的人类肿瘤和正常粘膜和皮肤标本以及原发性皮肤和口腔肿瘤培养物的分子谱资源)，并通过项目特定课程使学员能够将基础科学转化为临床治疗。这些活动包括每月联合实验室会议，由学员和皮肤科研究实验室进行研究报告，以及由学员选择的外部演讲者；“转化主题”论坛和高影响力转化（HIT）杂志俱乐部，以居民和科学家的联合报告为特色；强制性咨询委员会会议；以及教学，职业发展和负责任的研究培训行为。科学范围包括肿瘤、内皮细胞、免疫细胞等间质细胞的稳态和致癌机制（c-Myc、Ras和B-Raf、IGFs、Trim32、Wnt、EGFR、RXR、CTIP、CDKN2A/p16、MC1R、细胞因子及其受体）、基质和分泌因子的作用。每年任命两名博士预科生和三名博士后博士，博士或博士/博士候选人，选择资质，提供该领域的特殊经验，并希望纳入强大的翻译

DESCRIPTION (provided by applicant): The OHSU Department of Dermatology proposes continuation of its 10-year "Training in the Molecular Basis of Skin/Mucosa Pathobiology" program, with the objective of preparing highly qualified pre-doctoral and postdoctoral researchers for academic careers that lead to better understanding and treatment of skin, oral and intestinal cancers. Currently the only NCI-funded training program at OHSU, our program focuses on cancers that are accessible from their earliest stages, and thus ideal for understanding multi-step carcinogenesis, testing prevention strategies, and targeting and monitoring success of treatments. Specifically, we aim: 1. to engage trainees in furthering an understanding of the molecular pathways that underlie skin/mucosa disease, in evolving and using specialized approaches to advance the field, and in providing insight and ultimately applications to clinical problems~ and 2. to foster interactions among mentor/trainee laboratories that enrich the dermatology field and increase its scope and impact on understanding and treating cancer and inflammatory disease. The program offers internationally recognized faculty researchers from dermatology, 6 basic science departments and 5 OHSU institutes and centers, who are dedicated to training the next generation and collaborating to form a focus on carcinogenesis, diagnostics, prevention and treatment of cancer and inflammatory disease. The program engages trainees and mentors in sharing of ideas and specialized resources (keratinocyte- and melanocyte-targeted inducible genetic models of skin, colon and head and neck cancer and inflammatory disease~ non-invasive optical imaging~ specialized cell isolation of epithelial and immun populations~ the Molecular Profiling Resource containing freshly cryopreserved human tumor and normal mucosa and skin specimens and primary skin and oral tumor cultures), and exposes trainees to translation of basic science to clinical treatment through program-specific curriculum. These include monthly Joint Lab meeting for research presentations by trainees and dermatology research laboratories as well as outside speakers selected by trainees~ the forums "Translational Topics" and High Impact Translational (HIT) journal club that feature joint presentations of residents and scientists~ mandatory advisory committee meetings~ and didactic, career development and responsible conduct of research training. The scientific scope includes homeostatic and oncogenic mechanisms (c-Myc, Ras and B-Raf, IGFs, Trim32, Wnt, EGFR, RXR, CTIP, CDKN2A/p16, MC1R, cytokines and their receptors) of tumor, endothelial, immune and other stromal cell cross talk and role of matrix and secreted factors. Two predoctoral and 3 postdoctoral MD, PhD or MD/PhD candidates are appointed each year, selected for aptitude, special experience to offer the field, desire to incorporate a strong translational component and potential for impact on investigative dermatology in skin/mucosa cancer and inflammation.