Training in the Molecular Basis of Skin/Mucosa Pathobiology

描述(由申请者提供)：OHSU皮肤科建议继续其为期10年的“皮肤/粘膜病理生物学分子基础培训”计划，目的是为学术生涯培养高素质的博士后和博士后研究人员，从而更好地了解和治疗皮肤、口腔和肠癌。目前，我们的项目是OHSU唯一由NCI资助的培训项目，我们的项目专注于从早期阶段就可以接触到的癌症，因此是了解多步骤癌症发生、测试预防策略以及针对和监测治疗成功的理想选择。具体地说，我们的目标是：1.让受训者进一步了解皮肤/粘膜疾病背后的分子途径，发展和使用专门的方法来推动该领域的发展，并提供洞察力并最终应用于临床问题~2.促进导师/受训实验室之间的互动，以丰富皮肤病领域，扩大其范围和影响，了解和治疗癌症和炎症性疾病。该项目提供来自皮肤科、6个基础科学系和5个OHSU研究所和中心的国际公认的教职员工研究人员，他们致力于培训下一代，并合作形成对癌症和炎症性疾病的发生、诊断、预防和治疗的关注。该计划让受训者和导师分享想法和专业资源(角质形成细胞和黑素细胞靶向诱导皮肤、结肠癌、头颈部癌症和炎症性疾病的可诱导遗传模型；非侵入性光学成像；上皮和免疫细胞群体的专门细胞分离；包含新鲜冷冻保存的人类肿瘤和正常黏膜、皮肤标本和原代皮肤和口腔肿瘤培养的分子图谱资源)，并通过特定于计划的课程使受训者接触到将基础科学转化为临床治疗的机会。这些活动包括每月联合实验室会议，由受训者和皮肤病研究实验室以及由受训者选择的外部演讲者进行研究演讲~论坛“翻译主题”和高影响力翻译(HIT)期刊俱乐部，以住院医生和科学家的联合演讲为特色~强制性咨询委员会会议~以及教学、职业发展和负责任的研究培训。科学范围包括肿瘤、内皮细胞、免疫细胞和其他基质细胞的稳态和致癌机制(c-Myc、RAS和B-Raf、IGFS、Trim32、Wnt、EGFR、RXR、CTIP、CDKN2A/p16、MC1R、细胞因子及其受体)以及基质和分泌因子的作用。每年任命两名博士后和三名博士后，根据他们的能力、特殊经验来挑选他们，希望融入强大的翻译能力 对皮肤癌/粘膜癌和炎症的皮肤科研究的组成部分和潜在影响。

DESCRIPTION (provided by applicant): The OHSU Department of Dermatology proposes continuation of its 10-year "Training in the Molecular Basis of Skin/Mucosa Pathobiology" program, with the objective of preparing highly qualified pre-doctoral and postdoctoral researchers for academic careers that lead to better understanding and treatment of skin, oral and intestinal cancers. Currently the only NCI-funded training program at OHSU, our program focuses on cancers that are accessible from their earliest stages, and thus ideal for understanding multi-step carcinogenesis, testing prevention strategies, and targeting and monitoring success of treatments. Specifically, we aim: 1. to engage trainees in furthering an understanding of the molecular pathways that underlie skin/mucosa disease, in evolving and using specialized approaches to advance the field, and in providing insight and ultimately applications to clinical problems~ and 2. to foster interactions among mentor/trainee laboratories that enrich the dermatology field and increase its scope and impact on understanding and treating cancer and inflammatory disease. The program offers internationally recognized faculty researchers from dermatology, 6 basic science departments and 5 OHSU institutes and centers, who are dedicated to training the next generation and collaborating to form a focus on carcinogenesis, diagnostics, prevention and treatment of cancer and inflammatory disease. The program engages trainees and mentors in sharing of ideas and specialized resources (keratinocyte- and melanocyte-targeted inducible genetic models of skin, colon and head and neck cancer and inflammatory disease~ non-invasive optical imaging~ specialized cell isolation of epithelial and immun populations~ the Molecular Profiling Resource containing freshly cryopreserved human tumor and normal mucosa and skin specimens and primary skin and oral tumor cultures), and exposes trainees to translation of basic science to clinical treatment through program-specific curriculum. These include monthly Joint Lab meeting for research presentations by trainees and dermatology research laboratories as well as outside speakers selected by trainees~ the forums "Translational Topics" and High Impact Translational (HIT) journal club that feature joint presentations of residents and scientists~ mandatory advisory committee meetings~ and didactic, career development and responsible conduct of research training. The scientific scope includes homeostatic and oncogenic mechanisms (c-Myc, Ras and B-Raf, IGFs, Trim32, Wnt, EGFR, RXR, CTIP, CDKN2A/p16, MC1R, cytokines and their receptors) of tumor, endothelial, immune and other stromal cell cross talk and role of matrix and secreted factors. Two predoctoral and 3 postdoctoral MD, PhD or MD/PhD candidates are appointed each year, selected for aptitude, special experience to offer the field, desire to incorporate a strong translational component and potential for impact on investigative dermatology in skin/mucosa cancer and inflammation.