Training in the Molecular Basis of Skin/Mucosa Pathobiology

皮肤/粘膜病理学分子基础培训

• 批准号: 9116807
• 负责人: MOLLY F. KULESZ-MARTIN
• 金额: $ 25.16万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9116807
• 关键词: Molecular; Mucous Membrane; Skin; Training; base

DESCRIPTION (provided by applicant): The OHSU Department of Dermatology proposes continuation of its 10-year "Training in the Molecular Basis of Skin/Mucosa Pathobiology" program, with the objective of preparing highly qualified pre-doctoral and postdoctoral researchers for academic careers that lead to better understanding and treatment of skin, oral and intestinal cancers. Currently the only NCI-funded training program at OHSU, our program focuses on cancers that are accessible from their earliest stages, and thus ideal for understanding multi-step carcinogenesis, testing prevention strategies, and targeting and monitoring success of treatments. Specifically, we aim: 1. to engage trainees in furthering an understanding of the molecular pathways that underlie skin/mucosa disease, in evolving and using specialized approaches to advance the field, and in providing insight and ultimately applications to clinical problems~ and 2. to foster interactions among mentor/trainee laboratories that enrich the dermatology field and increase its scope and impact on understanding and treating cancer and inflammatory disease. The program offers internationally recognized faculty researchers from dermatology, 6 basic science departments and 5 OHSU institutes and centers, who are dedicated to training the next generation and collaborating to form a focus on carcinogenesis, diagnostics, prevention and treatment of cancer and inflammatory disease. The program engages trainees and mentors in sharing of ideas and specialized resources (keratinocyte- and melanocyte-targeted inducible genetic models of skin, colon and head and neck cancer and inflammatory disease~ non-invasive optical imaging~ specialized cell isolation of epithelial and immun populations~ the Molecular Profiling Resource containing freshly cryopreserved human tumor and normal mucosa and skin specimens and primary skin and oral tumor cultures), and exposes trainees to translation of basic science to clinical treatment through program-specific curriculum. These include monthly Joint Lab meeting for research presentations by trainees and dermatology research laboratories as well as outside speakers selected by trainees~ the forums "Translational Topics" and High Impact Translational (HIT) journal club that feature joint presentations of residents and scientists~ mandatory advisory committee meetings~ and didactic, career development and responsible conduct of research training. The scientific scope includes homeostatic and oncogenic mechanisms (c-Myc, Ras and B-Raf, IGFs, Trim32, Wnt, EGFR, RXR, CTIP, CDKN2A/p16, MC1R, cytokines and their receptors) of tumor, endothelial, immune and other stromal cell cross talk and role of matrix and secreted factors. Two predoctoral and 3 postdoctoral MD, PhD or MD/PhD candidates are appointed each year, selected for aptitude, special experience to offer the field, desire to incorporate a strong translational component and potential for impact on investigative dermatology in skin/mucosa cancer and inflammation.

描述（由申请人提供）：OHSU皮肤病学系建议继续其为期10年的“皮肤/粘膜病理学分子基础培训”计划，目的是为学术生涯准备高素质的博士前和博士后研究人员，从而更好地了解和治疗皮肤，口腔和肠道癌症。目前在OHSU唯一的NCI资助的培训计划，我们的计划侧重于从他们的最早阶段可访问的癌症，因此非常适合了解多步骤致癌，测试预防策略，并针对和监测治疗的成功。具体来说，我们的目标是：1。让学员进一步了解皮肤/粘膜疾病的分子途径，发展和使用专门的方法来推进该领域，并提供洞察力和最终应用于临床问题。促进导师/实习生实验室之间的互动，丰富皮肤病学领域，并增加其对理解和治疗癌症和炎症性疾病的范围和影响。该计划提供来自皮肤科，6个基础科学部门和5个OHSU研究所和中心的国际公认的教师研究人员，他们致力于培训下一代，并合作形成对癌症和炎症性疾病的致癌，诊断，预防和治疗的重点。 该计划让学员和导师分享想法和专业资源（皮肤的角化细胞和黑素细胞靶向的诱导型遗传模型，结肠和头颈部癌症和炎性疾病~非侵入性光学成像~上皮和免疫群体的专门细胞分离~包含新鲜冷冻保存的人肿瘤和正常粘膜和皮肤样本以及原代皮肤和口腔肿瘤培养物的分子谱资源），并通过具体方案的课程，使受训者了解如何将基础科学转化为临床治疗。 这些包括每月的联合实验室会议，由学员和皮肤病学研究实验室以及由学员选择的外部演讲者进行研究演示~论坛“翻译主题”和高影响力翻译（HIT）期刊俱乐部，其特点是居民和科学家的联合演示~强制性咨询委员会会议~和说教，职业发展和负责任地开展研究培训。科学范围包括肿瘤、内皮、免疫和其他基质细胞串扰的稳态和致癌机制（c-Myc、Ras和B-Raf、IGFs、Trim 32、Wnt、EGFR、RXR、CTIP、CDKN 2A/p16、MC 1 R、细胞因子及其受体）以及基质和分泌因子的作用。 每年任命两名博士前和3名博士后MD，博士或MD/博士候选人，选择能力，提供该领域的特殊经验，希望将强大的翻译 成分和对皮肤/粘膜癌和炎症研究皮肤病学的潜在影响。