Analysis Core

分析核心主要通过数据管理和统计分析服务支持POI研究计划项目资助的四个研究项目的科学目标。在这个角色中，通过与优化核心和其他计划项目研究人员的合作，分析核心将应用和解释统计技术来分析研究项目数据，以支持吸烟慢性护理治疗的发展。分析核心提供的服务包括：1）清洁，准备（例如，2）进行统计分析，以解决与研究项目相关的主要和次要目标，包括使用各种方法分析研究项目的关键成果：混合效应回归模型适用于单终点，纵向二元，和连续的结果，以检查主要和相互作用的影响;中介分析，允许识别替代结果变量和调查机制的治疗效果;确定和应用各种技术，综合多种成果的结果，特别是在多阶段优化战略方法的筛选阶段;以及进行成本效益分析，以便根据治疗成本评估治疗结果;和3）与项目负责人和核心主任协调和咨询，以制定分析计划，确保分析解决临床和实质性的重要研究目标，并整合跨项目的研究结果。分析核心的成员将定期与研究人员会面，以确保研究计划实施的科学完整性，监测和讨论整体进展以及具体项目需求，并就分析核心提供的资源的优先级和分配做出决定。

The Analysis Core supports the scientific objectives of the four research projects of the POI Research Program Project Grant primarily through data management and statistical analysis services. In this role, and through collaboration with Optimization Core and other Program Project investigators, the Analysis Core will apply and interpret statistical techniques for analyzing research project data to support the development of a chronic care treatment for smoking. Services provided by the Analytic Core include: 1) cleaning, preparing (e.g., scoring of measures), documenting, and sharing of research project data for subsequent statistical analysis; 2) conducting statistical analyses to address primary and secondary aims associated with the research projects, including analysis of key outcomes for the research projects using a variety of approaches: mixed effects regression models as appropriate for single endpoint, longitudinal binary, and continuous outcomes to examine main and interaction effects; mediational analyses that permit identification of surrogate outcome variables and investigate the mechanism of treatment effects; identification and application of techniques to synthesize results across multiple outcomes, particularly in the screening stages of the Multiphase Optimization Strategy (MOST) approach; and implementation of cost-effectiveness analyses that will permit evaluation of treatment outcomes in relation to cost of treatment; and 3) coordinating and consulting with Project Leaders and Core Directors to develop analytic plans that ensure analyses address clinically and substantively important research goals and that integrate findings across projects. Members of the Analytic Core will meet regularly with investigators to ensure the scientific integrity of the implementation of the research plan, to monitor and discuss overall progress as well as specific project needs, and to make decisions related to prioritization and allocation of resources provided by the Analysis Core.