Interferon epsilon, a key cytokine in the pathophysiology of the female reproductive tract mucosa

干扰素ε，女性生殖道粘膜病理生理学中的关键细胞因子

• 批准号: nhmrc : 1139649
• 负责人: Dr Niamh Mangan
• 金额: $ 53.64万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interferon-epsilon-key-tract-mucosa/1319053
• 关键词: Interferon; epsilon; key; cytokine; pathophysiology

The female reproductive tract is a complex environment, which permits pregnancy but protects against infections, all under the influence of hormones and the resident microbial flora. We have discovered a novel protein called interferon epsilon that acts on cells in the female reproductive tract to regulate protection against infections. We aim to discover how this new protein works and will determine its therapeutic potential in infections and inflammatory diseases affecting women's health.

女性生殖道是一个复杂的环境，它允许怀孕，但保护免受感染，所有这些都受到激素和常驻微生物植物群的影响。我们发现了一种新的蛋白质，称为干扰素α，作用于女性生殖道细胞，以调节对感染的保护。我们的目标是发现这种新蛋白质是如何工作的，并将确定其在影响女性健康的感染和炎性疾病中的治疗潜力。