Interferon Regulatory Factor 6: a novel epithelial-specific regulator of mucosal inflammation

干扰素调节因子 6：粘膜炎症的新型上皮特异性调节因子

• 批准号: nhmrc : 628769
• 负责人: A/Pr Glen Scholz
• 金额: $ 34.54万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interferon-regulatory-factor-mucosal-inflammation/80909
• 关键词: Interferon; Regulatory; Factor; novel; epithelial

Epithelial cells lining the respiratory and gastrointestinal tracts play pivotal roles in protecting us from infection. Inflammatory factors released by epithelial cells are important for fighting infection; however, they also contribute to chronic inflammatory diseases. We aim to understand how a protein called IRF6 regulates the inflammatory response of epithelial cells. The knowledge gained will identify new therapeutic approaches for inflammatory diseases.

呼吸道和胃肠道的上皮细胞在保护我们免受感染方面起着关键作用。上皮细胞释放的炎症因子对于抵抗感染很重要;然而，它们也会导致慢性炎症性疾病。我们的目标是了解一种名为IRF 6的蛋白质如何调节上皮细胞的炎症反应。所获得的知识将为炎症性疾病确定新的治疗方法。