Acquisition of an X-Rad 320 Biological Irradiator

购买 X-Rad 320 生物辐照器

• 批准号: 8703903
• 负责人: David E Levy
• 金额: $ 16.47万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-17 至 2016-02-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8703903
• 关键词: Animal Housing; Animals; Area; Basic Science; Biological; Cancer Immunology Science; Cardiology; Cesium; Cobalt; Communicable Diseases; DNA Repair; Data; Faculty; Frequencies; Funding; Future; Housing; Hurricane; Inflammation; Isotopes; Laboratories; Minor; Procedures; Radiation; Radioactive; Radioisotopes; Recruitment Activity; Reliance; Research; Research Personnel; Research Project Grants; Resources; Rodent; Science; Security; Source; Translational Research; Tube; United States National Institutes of Health; base; instrument; irradiation

DESCRIPTION (provided by applicant): We are requesting funds for a Precision X-Rad 320 Biological Irradiator. This instrument will provide 450kB high stability, high frequency x-rays, providing a highly reproducible and coherent irradiation field. There are numerous research projects at NYULMC that rely on the ability to deliver controlled irradiation to experimental rodents housed within the barrier vivarium. Due to Hurricane Sandy, the irradiator in the Smilow Central Animal Vivarium was destroyed. The vivarium is being reconstructed in the West Tower of the Alexandria Center. Availability of an animal irradiator is vital for ongoing projects on animals to be housed in this vivarium. A major advantage of the requested instrument is its reliance on an x-ray tube as a radiation source, rather that the more traditional isotope irradiators that contain radioactive cesium or cobalt. Thus, the X-Rad 320 lacks the major Homeland Security concerns inherent in maintaining a radioisotope-based irradiator, greatly simplifying installation, use, and oversight. The Precision X-Rad 320 will be placed within a shared procedure space within the West Tower Vivarium, where is will be available for use by the laboratory staff of the major user group, as well as ancillary minor users. The unit will be under the oversight of the Division of Laboratory Resources of the Office of Science and Research. It will be directly administered by the PI of this application, Assoc. Dean David Levy and his administrative staff in the Office of Collaborative Science. The major and minor user group comes from numerous academic departments and represents both basic and translational research areas, such as, cancer, immunology, infectious diseases, cardiology, inflammation, and DNA repair. The NIH funded users combined will use 75% of the instrument capacity. Remaining instrument capacity will be made available to any researcher with animals housed in the vivarium through an on-line scheduler. These investigators will be largely newly-recruited junior faculty who are gathering data in support of their first submissions to NIH. The availability of this instrument in a Core setting will make it fully available to all users, includng future users as they acquire NIH funding and research needs of animal irradiation. Although there are other animal irradiators on campus, the special needs of research on animals housed under barrier conditions require that each barrier vivarium have its own irradiator. Therefore, there is no substitute for a dedicated irradiator such as this within the West Tower Vivarium.

描述（由申请人提供）：我们正在申请Precision X-Rad 320生物辐照器的资金。该仪器将提供450 kB高稳定性、高频X射线，提供高度可重复性和相干的辐照场。NYULMC有许多研究项目依赖于向屏障动物园内的实验啮齿动物提供受控辐射的能力。由于飓风桑迪，斯米洛中央动物饲养场的辐照器被摧毁。动物园正在亚历山大中心的西塔重建。动物辐照器的可用性对于正在进行的动物饲养项目至关重要。所要求的仪器的一个主要优点是它依赖于X射线管作为辐射源，而不是含有放射性铯或钴的更传统的同位素辐照器。因此，X-Rad 320没有维护放射性同位素辐照器所固有的主要国土安全问题，大大简化了安装，使用和监督。Precision X-Rad 320将放置在西塔动物园内的共享手术空间内，供主要用户组的实验室工作人员以及辅助次要用户使用。该单位将接受科学和研究办公室实验室资源司的监督。它将直接由本申请的PI，副院长大卫利维和他的行政人员在合作科学办公室管理。主要和次要用户群来自许多学术部门，代表基础和转化研究领域，如癌症，免疫学，传染病，心脏病，炎症和DNA修复。NIH资助的用户将使用75%的仪器容量。剩余的仪器容量将通过在线调度程序提供给动物饲养在动物园中的任何研究人员。这些研究人员将主要是新招募的初级教师，他们正在收集数据，以支持他们向NIH提交的第一份报告。该仪器在核心环境中的可用性将使其完全可供所有用户使用，包括未来的用户，因为他们获得了NIH的资金和动物辐照的研究需求。虽然校园里有其他动物辐照器，但对屏障条件下饲养的动物进行研究的特殊需要要求每个屏障饲养场都有自己的辐照器。因此，在西塔动物园内，没有专用辐照器的替代品。