Cannabinoid regulation of cognition

描述(申请人提供)：大麻仍然是美国最受欢迎的非法精神活性药物。大约70%-80%的40-50岁的人一生中至少尝试过一次，18-21岁的人中有18%-19%的人在过去的一个月里使用过大麻。在美国，符合大麻依赖标准的人比在过去一个月里使用可卡因或尝试过海洛因的人还多；更令人担忧的是，随着药房的激增，医用大麻法律规定的大麻使用在美国继续扩大。例如，在发现吸食大麻或联合使用大麻素喷雾可以改善多发性硬化症的症状后，增加医疗使用量的趋势可能会继续下去。研究表明，急性大麻中毒会损害认知功能，但一些大麻品种的成分大麻二酚(CBD)可能会提供一些保护，使其免受大麻的急性和持久有害影响。该项目的研究试图利用非人类灵长类动物模型，确定CBD是否可以减轻D9-四氢大麻酚(THC)引起的特定认知障碍。一系列对THC敏感的测试将被用来确定CBD是否可以阻断急性和长期服用THC的影响。我们的目标是确定CBD在治疗环境中可以在多大程度上用于缓解THC的影响，尽管这对娱乐使用者也有影响。

DESCRIPTION (provided by applicant): Cannabis remains the most popular illicit psychoactive drug used in the US. Some 70-80 percent of 40- 50 year olds have tried it at least once in their lifetime and 18-19 percent of 18-21 years olds have used cannabis in the past month. There are more people in the US who meet criteria for cannabis dependence than have used cocaine in the past month or ever tried heroin; it is of further concern that the use of cannabis under medical marijuana laws continues to expand in the US as dispensaries proliferate. Trends for increased medical use may continue following, e.g., findings that smoked marijuana or a combined-cannabinoid spray can improve symptoms in multiple sclerosis. Studies have shown that acute intoxication with cannabis impairs cognitive function, however cannabidiol (CBD), a constituent of some cannabis strains, may provide some protection from the acute and lasting detrimental effects of cannabis. The studies in this project seek to determine if CBD can attenuate specific cognitive disruptions caused by D9-tetrahydrocannabinol (THC), using a nonhuman primate model. A battery of tests shown sensitive to THC will be used to determine if CBD can block the effects of both acute and chronic administration of THC. The goal is to determine the extent to which CBD might be used to moderate effects of THC in the therapeutic setting, although there are also implications for the recreational user.