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Dissecting the Abuse Liability of Cathinone and Amphetamine Stimulants

剖析卡西酮和安非他明兴奋剂的滥用责任

基本信息

批准号：
10668867
负责人：
MICHAEL A. TAFFE
金额：
$ 39.5万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-30 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10668867
关键词：
Abstinence Acute Address Admission activity Adult African American population Alcohols Amphetamines Animal Model Annual Reports Attention Behavior Behavioral Bite Brain Cessation of life Clinical Laboratory Information Systems Cocaine Consumption Data Dependence Development Exhibits Forensic Medicine Goals Health Human Imprisonment Individual Intake Intervention Intravenous Investigation Law Enforcement Maintenance Methamphetamine Methamphetamine use disorder Modeling Native Americans Negative Reinforcements Not Hispanic or Latino Opioid Oxycodone Pattern Personal Satisfaction Pharmaceutical Preparations Phenotype Population Psychotropic Drugs Rattus Reporting Rewards Role Self Administration Self Stimulation Stimulant Testing United States United States Substance Abuse and Mental Health Services Administration Update Vaccine Therapy Waxes abuse liability addiction analog bath salts cathinone caucasian American cost diagnostic criteria experience experimental study indexing methamphetamine use methamphetamine user mortality novel preclinical study prevent psychostimulant reinforcer small molecule socioeconomics stimulant abuse stimulant dependence stimulant use stimulant use disorder stimulant user substance use treatment trafficking

项目摘要

The abuse of psychomotor stimulants, including cocaine and methamphetamine, as well as the synthetic cathinone drugs (“bathsalts”), continues to wreak havoc worldwide and in the United States of America, with most individuals that suffer with stimulant use disorders going untreated. The more established stimulants such as cocaine and methamphetamine are highly addictive, can be acutely lethal and can result in long-term brain alterations with many implications for health and well-being. Recent studies show that synthetic cathinone psychoactive drugs 3,4-methylenedioxypyrovalerone (MDPV), α-pyrrolidinopentiophenone (α-PVP) and associated close analogs are a highly potent and efficacious reinforcers in animal models. These compounds tend to be used as cheaper or more available substitutes in lower socioeconomic populations, by incarcerated individuals, etc. Efforts to develop small molecule or vaccine therapies for psychomotor stimulant dependence have not, as yet, succeeded. It continues to be critical to better understand how stimulant dependence is established and maintained so as to better prevent stimulant addiction before it is established. This project will investigate the situational and behavioral contributors to escalating stimulant drug taking in rat models of intravenous self-administration, consistent with the goals of NOSI NOT-DA-21-028. Studies proposed under Aim I will determine if binge-like acquisition of psychostimulant self-administration alters the propensity for escalated intake under extended access conditions. The goal is to understand the consequences of initial uncontrolled consumption and whether that has lasting consequences for dependence. Studies under Aim II will determine if the intra-cranial self-stimulation (ICSS) reward threshold indexes the escalation in self-administration under extended access conditions, in a novel test of a longstanding negative-reinforcement framework for understanding escalating stimulant use. Finally, investigations under Aim III will determine if alternating cathinone and methamphetamine use alters the escalation of self-administration. These novel poly-drug models will address an understudied phenomenon whereby some human stimulant users substitute drugs depending on cost and availability. In total, these proposed studies will advance our understanding of the development of dependence on psychomotor stimulant drugs.

滥用精神运动兴奋剂，包括可卡因和甲基苯丙胺，以及

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Binge-like acquisition of α-pyrrolidinopentiophenone (α-PVP) self-administration in female rats.

DOI：
10.1007/s00213-018-4943-3
发表时间：
2018-08
期刊：
Psychopharmacology
影响因子：
3.4
作者：
Javadi-Paydar M;Harvey EL;Grant Y;Vandewater SA;Creehan KM;Nguyen JD;Dickerson TJ;Taffe MA
通讯作者：
Taffe MA

Effects of α-pyrrolidino-phenone cathinone stimulants on locomotor behavior in female rats.

DOI：
10.1016/j.drugalcdep.2021.108910
发表时间：
2021-10-01
期刊：
DRUG AND ALCOHOL DEPENDENCE
影响因子：
4.2
作者：
Taffe, Michael A.;Nguyen, Jacques D.;Vandewater, Sophia A.;Grant, Yanabel;Dickerson, Tobin J.
通讯作者：
Dickerson, Tobin J.