Nathan Shock Ctr ofExcellence in Basic Biology of Aging

内森休克衰老基础生物学卓越中心

• 批准号: 8912699
• 负责人: PETER S RABINOVITCH
• 金额: $ 5.54万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8912699
• 关键词: Age; Aging; Biological; Biology of Aging; Cellular Assay; Communities; Environment; Funding; Gene Expression; Genetic; Health; Institution; Knock-out; Longevity Pathway; Modeling; Mutation; Neighborhoods; Office of Administrative Management; Organ; Pathway interactions; Physiological; Pilot Projects; Post-Translational Protein Processing; Proteomics; Research; Research Activity; Research Personnel; Resources; Shock; Technology; Transgenic Animals; Universities; Washington; animal model development; comparative; data sharing; functional genomics; mouse model; programs; protein degradation; research and development; transcriptomics

DESCRIPTION (provided by applicant): This application is for renewal of the Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington and affiliated institutions. This Center has over the past 15 years provided resources in support of our large community of investigators that are funded to study basic biological mechanisms of aging. We continue to build upon a scientific theme that became established in the past funding cycle, in which comparative gerontologic study informed us of conserved genetic pathways of longevity determination (the TOR pathway is an example of one such). The three proposed Research Resources Core components are well suited to assist in such efforts: 1) Transgenic Animal Model Development; 2) Functional Assessment; 3) Functional Genomics. The Transgenic Animal Model Development Resource Core continues to pursue a focus on inducible gene expression and knockout models, so that organ and age-specific effects of genetic alterations can be assessed. The Functional Assessment Core builds upon technical resources that have been gathered during the past funding period, such that we can now provide investigators with a broad and informative range of physiologic and cellular assays, including those that are most relevant to assessment of the healthspan of mouse models. The Functional Genomics Core provides expert assistance with state of the art technologies for transcriptomics and proteomics. Consistent with our theme, it includes a focus on translational state, protein turnover and post-translational modification. The Research Development Core will continue to support pilot study projects in the basic biology of aging. The Program Enrichment Core supports administrative management, an external advisory panel, a program of courses and seminars and data sharing and dissemination.

描述（由申请人提供）：本申请是华盛顿大学衰老基础生物学卓越中心及其附属机构的续期申请。在过去的15年里，该中心为我们的大型研究人员社区提供了资源支持，这些研究人员被资助研究衰老的基本生物学机制。我们继续建立在过去的资助周期中建立的科学主题上，其中比较老年学研究告诉我们决定寿命的保守遗传途径（TOR途径就是这样一个例子）。提出的三个研究资源核心组成部分非常适合协助这些努力：1)转基因动物模型开发；2)功能评估；3)功能基因组学。转基因动物模型开发资源核心继续致力于诱导基因表达和敲除模型，以便评估遗传改变的器官和年龄特异性影响。功能评估核心建立在过去资助期间收集的技术资源的基础上，因此我们现在可以为研究人员提供广泛而翔实的生理和细胞分析，包括那些与评估小鼠模型健康跨度最相关的分析。功能基因组学核心为转录组学和蛋白质组学提供最先进技术的专家协助。与我们的主题一致，它包括关注翻译状态，蛋白质周转和翻译后修饰。研究发展核心将继续支持老化基础生物学的试点研究项目。计划浓缩核心支持行政管理、外部咨询小组、课程和研讨会计划以及数据共享和传播。