Northwestern University Skin Disease Research Core Center

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DESCRIPTION (provided by applicant): Northwestern University (NU) is recognized for its strong interdisciplinary cutaneous biology research program. The SDRC, with its 73 members, encompassing 14 university departments and 7 divisions within the Department of Medicine, has played a major role in maintaining and expanding this research program. The goal of the Northwestern University SDRC has been and will continue to be the promotion of outstanding translational research in cutaneous biology, ultimately to improve patient care. To accomplish this goal, the SDRC has the following Cores: (i) Administration; (ii) Skin Tissue Engineering; (iii Morphology and Phenotyping; and (iv) DNA/RNA Delivery. The Administrative Core encourages collaboration among the 60 SDRC Bench Research members and the 13 Clinical Collaborator Associate members through its Enrichment Program. Within the Enrichment Program, the SDRC will continue to support the highly successful Pilot and Feasibility (P&F) Program, which has brought new members into the SDRC and opened novel areas of research in cutaneous biology. The Administrative Core will further expand its successful Minority and Gender Awareness Program, through the support of two new research areas focusing on understanding better the cutaneous differences in skin of color as well as gender. The Skin Tissue Engineering Core provides keratinocytes, including organotypic cultures, and will extend this service to offer fibroblasts, melanocytes, cells from patient lesional skin, and organotypic culture models of skin disease. The Morphology and Phenotyping Core offers a broad-based tissue bank, in addition to its morphogenetic processing services, laser capture micro-dissection capabilities, and assays to test penetration into human skin. The DNA/RNA Delivery Core generates lentiviral and retroviral constructs to overexpress or silence genes, and to express reporters in skin cells. All three Research Cores provide education through training and interpretation of results and have strong translational components. The SDRC has partnered with several NU Core facilities to provide users with opportunities to take their basic findings into a clinical setting, thus positioning itself to make important strides in understanding and treating diseases of the skin.