Northwestern University Skin Disease Research Core Center

描述（由申请人提供）：西北大学上皮生物学研究计划（EBRI）是公认的研究卓越的宝石，既长期存在，又不断扩大。这项研究代表了我们来自11个部门的国内和国际公认的上皮生物学家的努力。卓越的研究集中在以下领域：(i)细胞-细胞和细胞基质粘附结构及其与大疱性疾病、传染病和锥体化失调的关系；（ii）细胞运动、伤口愈合和细胞外基质重塑；（iii）细胞信号传导、增殖、分化和癌变；（iv）感染性或炎症性疾病影响角质形成细胞的机制；（五）干细胞生物学。这五个领域的研究已经从基本发现发展而来。此外，临床医生和实验室科学家之间不断升级的交流已经导致了一些转化研究合作。西北大学SDRC将：a)促进EBRI科学家之间更大的合作互动；B)为正在进行的上皮生物学研究项目提供支持机制，并确保这些机制的设计以最佳方式促进协作和有效的合作努力；C)促进基础科学家和临床科学家之间的沟通，使转化研究合作能够取得成果；d)巩固和扩大上皮生物学相关研究的研究基础。西北SDRC将提供科学核心设施；用于试点和可行性项目的资源；将项目从实验室过渡到临床领域的便利途径；以及协调全校上皮相关活动的行政机构（例如，研讨会、期刊俱乐部、资金信息）。将建立四个新的核心，包括管理核心，角质细胞核心，病理核心和DNA/RNA递送核心，所有这些核心都将与现有的皮肤翻译核心相互作用。四个试点和可行性项目在性质上各不相同，在所有情况下都代表了新的研究领域，并吸引了新的上皮生物学研究人员。西北大学SDRC的长期目标是为正常和病理上皮过程提供新的见解和方法，从而实现我们在上皮生物学方面提供一流转化研究的最终目标。通过SDRC设备，西北大学杰出的基础科学和临床研究人员将准备推进上皮生物学和皮肤病学，最终加速我们对疾病的理解，并产生改善患者护理的发现。

DESCRIPTION (provided by applicant): The Epithelial Biology Research Initiative (EBRI) at Northwestern University is a recognized jewel of research excellence that is both long-standing and continually expanding. This research represents the efforts of our nationally and internationally recognized epithelial biologists from 11 departments. Research excellence concentrates in the following areas:(i) cell-cell and cell matrix adhesive structures and their relation to bullous diseases, infectious diseases and disorders of cornification; (ii) cell motility, wound healing and remodeling of the extracellular matrix; (iii) cell signaling, proliferation, differentiation and carcinogenesis; (iv) mechanisms by which infectious or inflammatory disorders affect keratinocytes; and (v) stem cell biology. Research in these 5 areas has been evolving from basic discoveries. Furthermore, escalating communication among clinicians and bench scientists has led to several translational research collaborations. The Northwestern University SDRC will: a) foster even greater cooperative interactions among the scientists of the EBRI; b) provide support mechanisms for ongoing epithelial biology research projects and ensure that the design of these mechanisms optimally promotes collaboration and efficient cooperative efforts; c) facilitate the lines of communication between the basic and clinical scientists so that translational research collaborations can be brought to fruition; and d) both solidify and expand the research base in investigations related to epithelial biology. A Northwestern SDRC will provide scientific core facilities; resources for pilot and feasibility projects; a facilitated pathway for transitioning projects from the laboratory to the clinical arena; and an administrative facility that coordinates university-wide epithelial-related activities (e.g., seminars, journal clubs, funding information). Four new Cores will be established, including an Administrative Core, Keratinocyte Core, Pathology Core, and a DNA/RNA Delivery Core, all of which will interact with an existing Skin Translational Core. Four pilot and feasibility projects are diverse in nature and in all cases represent both new areas of study and engage investigators new to epithelial biology. The long term goals of the Northwestern University SDRC are to provide novel insights and approaches into normal and pathological epithelial processes, thus realizing our ultimate objective of the delivery of first-class translational research in epithelial biology. Through the SDRC apparatus, Northwestern's remarkable group of basic science and clinical investigators will be poised to advance epithelial biology and dermatology, ultimately expediting our understanding of disease and resulting in discoveries that improve patient care.