Northwestern University Skin Disease Research Core Center

描述(由申请者提供)：西北大学的上皮生物学研究计划(EBRI)是公认的卓越研究的明珠，不仅存在已久，而且还在不断扩大。这项研究代表了我们来自11个部门的国内和国际公认的上皮生物学家的努力。研究成果集中在以下领域：(I)细胞-细胞和细胞基质黏附结构及其与大疱性疾病、传染病和角化障碍的关系；(Ii)细胞运动、伤口愈合和细胞外基质的重塑；(Iii)细胞信号、增殖、分化和致癌；(Iv)感染性或炎症性疾病影响角质形成细胞的机制；以及(V)干细胞生物学。这5个领域的研究一直是从基本发现演变而来的。此外，临床医生和实验室科学家之间不断升级的交流已经导致了几个转化性研究合作。西北大学国家发展研究中心将：a)促进EBRI科学家之间更大的合作互动；b)为正在进行的上皮生物学研究项目提供支持机制，并确保这些机制的设计以最佳方式促进协作和高效的合作努力；c)促进基础和临床科学家之间的沟通，使转译研究合作能够取得成果；以及d)巩固和扩大与上皮生物学相关研究的研究基础。西北发改委将提供科学核心设施；为试点和可行性项目提供资源；为项目从实验室过渡到临床舞台提供便利的途径；以及协调大学范围内与上皮相关的活动(例如，研讨会、期刊俱乐部、资助信息)的行政设施。将建立四个新的核心，包括管理核心、角质形成细胞核心、病理核心和DNA/RNA传递核心，所有这些核心都将与现有的皮肤翻译核心互动。四个试点和可行性项目的性质各不相同，在所有情况下都代表了新的研究领域，并吸引了对上皮生物学陌生的调查人员。西北大学SDRC的长期目标是为正常和病理的上皮过程提供新的见解和方法，从而实现我们的最终目标，即提供一流的上皮生物学转化研究。通过国家发改委的设备，西北大学杰出的基础科学和临床研究人员团队将准备推动上皮生物学和皮肤病学的发展，最终加快我们对疾病的了解，并产生改善患者护理的发现。

DESCRIPTION (provided by applicant): The Epithelial Biology Research Initiative (EBRI) at Northwestern University is a recognized jewel of research excellence that is both long-standing and continually expanding. This research represents the efforts of our nationally and internationally recognized epithelial biologists from 11 departments. Research excellence concentrates in the following areas:(i) cell-cell and cell matrix adhesive structures and their relation to bullous diseases, infectious diseases and disorders of cornification; (ii) cell motility, wound healing and remodeling of the extracellular matrix; (iii) cell signaling, proliferation, differentiation and carcinogenesis; (iv) mechanisms by which infectious or inflammatory disorders affect keratinocytes; and (v) stem cell biology. Research in these 5 areas has been evolving from basic discoveries. Furthermore, escalating communication among clinicians and bench scientists has led to several translational research collaborations. The Northwestern University SDRC will: a) foster even greater cooperative interactions among the scientists of the EBRI; b) provide support mechanisms for ongoing epithelial biology research projects and ensure that the design of these mechanisms optimally promotes collaboration and efficient cooperative efforts; c) facilitate the lines of communication between the basic and clinical scientists so that translational research collaborations can be brought to fruition; and d) both solidify and expand the research base in investigations related to epithelial biology. A Northwestern SDRC will provide scientific core facilities; resources for pilot and feasibility projects; a facilitated pathway for transitioning projects from the laboratory to the clinical arena; and an administrative facility that coordinates university-wide epithelial-related activities (e.g., seminars, journal clubs, funding information). Four new Cores will be established, including an Administrative Core, Keratinocyte Core, Pathology Core, and a DNA/RNA Delivery Core, all of which will interact with an existing Skin Translational Core. Four pilot and feasibility projects are diverse in nature and in all cases represent both new areas of study and engage investigators new to epithelial biology. The long term goals of the Northwestern University SDRC are to provide novel insights and approaches into normal and pathological epithelial processes, thus realizing our ultimate objective of the delivery of first-class translational research in epithelial biology. Through the SDRC apparatus, Northwestern's remarkable group of basic science and clinical investigators will be poised to advance epithelial biology and dermatology, ultimately expediting our understanding of disease and resulting in discoveries that improve patient care.