Interleukin 38: Uncoupling Innate Inflammation from Interferons in Lupus

系统性红斑狼疮（SLE）是一种无法治愈的自身免疫性疾病，影响全世界500万患者，其中大多数是年轻女性。严重的多器官炎症和预期寿命的大幅损失使SLE成为一个关键的未满足的医疗需求。我们发现免疫系统蛋白白细胞介素38使SLE进展所必需的几个信号通路失效。我们将探索这种蛋白质在健康人和SLE患者的细胞以及疾病模型中的调节和功能。

Systemic lupus erythematosus (SLE) is an incurable autoimmune disease that affects 5 million patients worldwide, mostly young women. Grave multi-organ inflammation and substantial loss of life expectancy render SLE a critical unmet medical need. We found that the immune system protein interleukin 38 disables several signalling pathways essential for SLE progress. We will explore regulation and function of this protein in cells from healthy people and SLE patients and in models of the disease.