Characterising the role of IL-37 in the development of H. pylori infection.

幽门螺杆菌感染了世界上50%以上的人口，是胃癌的病原体，胃癌是全球癌症相关死亡的第二大原因。幽门螺杆菌感染发生在儿童早期，并在宿主体内持续一生，引起免疫抑制，因此阻止个体清除感染。我们将研究幽门螺杆菌诱导人类免疫抑制的新机制，试图提供新的治疗方法。

H. pylori infects more than 50% of the worlds population and is the causative agent of gastric cancer, the second leading cause of cancer-related deaths worldwide. Infection with H. pylori occurs during early childhood and persists within the host for life, causing immune suppression and therefore preventing clearance of the infection from the individual. We will examine a newly identified mechanism of H. pylori-induced immune suppression in humans in an attempt to provide novel treatments.