An fMRI Study of TBI Associated with Blast Injury

与爆炸伤相关的 TBI 的功能磁共振成像研究

• 批准号: 8466797
• 负责人: HARVEY LEVIN
• 金额: --
• 依托单位: MICHAEL E DEBAKEY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8466797
• 关键词: Accounting; Address; Afghanistan; Amygdaloid structure; Animal Model; Area; Behavioral; Biological Neural Networks; Blast Cell; Blast Injuries; Brain; Brain imaging; Brain region; Cognitive; Cognitive deficits; Comorbidity; Complex; Corpus Callosum; Data; Diffusion Magnetic Resonance Imaging; Emotional; Enrollment; Functional Magnetic Resonance Imaging; Gray unit of radiation dose; Head and neck structure; Hippocampus (Brain); Human; Image; Injury; Iraq; Joints; Link; Magnetic Resonance Imaging; Maintenance; Measures; Mediating; Medical; Mental Depression; Military Personnel; Mission; Morbidity - disease rate; Outcome Measure; Parietal; Performance; Phase; Post-Traumatic Stress Disorders; Questionnaires; Registries; Reporting; Research; Response to stimulus physiology; Retrieval; Services; Severities; Short-Term Memory; Stress; Trauma; Traumatic Brain Injury; Veterans; abstracting; behavioral health; cognitive control; combat; comparison group; depressive symptoms; design; disability; functional outcomes; gray matter; health related quality of life; indexing; member; multimodality; neuromechanism; novel; rehabilitation service; relating to nervous system; response; white matter

DESCRIPTION (provided by applicant): 6. Project Summary/Abstract Traumatic brain injury (TBI) is a leading cause of morbidity and disability in service members deployed in Iraq and Afghanistan, accounting for one-fourth of medical evacuations. An explosive mechanism was linked to 78% of the clinician-confirmed injuries sustained by U.S. service members over a three-year period, and the head and neck were involved in 30% of these injuries. To elucidate the neural mechanisms mediating cognitive deficit after blast related TBI, we propose to perform multimodality brain imaging, cognitive, behavioral and health related quality of life outcome measures in veterans and service members who sustained TBI due to blast while deployed in Iraq or Afghanistan. A total of 84 veterans and service members will be enrolled between 4 and 60 months post-injury, including 28 who sustained moderate to severe blast related TBI, 28 with mild blast related TBI, and a comparison group who sustained injury not involving the brain. Functional magnetic resonance imaging (fMRI) will be performed during cognitive control and working memory tasks and analyzed in relation to the integrity of brain gray matter and white matter measured by magnetization transfer imaging and diffusion tensor imaging and brain region volumes measured by magnetic resonance imaging (MRI). We will also analyze fMRI data adjusting for co-morbid posttraumatic stress disorder and depression symptoms. With this design we propose to evaluate the effects of blast related TBI on brain function in relation to indices of brain structural integrity and co-morbidities of injury.

描述(由申请人提供)： 6.项目摘要/摘要创伤性脑损伤是部署在伊拉克和阿富汗的服役人员致病和致残的主要原因，占医疗后送的四分之一。在三年的时间里，78%的临床医生确认的美国军人受伤与爆炸机制有关，其中30%的受伤涉及头部和颈部。为了阐明爆炸相关脑损伤后认知障碍的神经机制，我们建议对在伊拉克或阿富汗部署时因爆炸而持续脑损伤的退伍军人和服役人员进行多模式脑成像、认知、行为和健康相关的生活质量结果测量。共有84名退伍军人和服役人员将在伤后4至60个月内入选，其中28人遭受中到重度冲击伤相关的脑损伤，28人患有轻度冲击伤相关的脑损伤，以及对照组遭受的非脑部损伤。功能磁共振成像(FMRI)将在认知控制和工作记忆任务中进行，并分析与磁化传递成像和扩散张量成像测量的大脑灰质和白质的完整性以及磁共振成像(MRI)测量的脑区体积的关系。我们还将分析调整创伤后应激障碍和抑郁症状的fMRI数据。通过这项设计，我们建议评估与冲击波相关的脑损伤对脑功能的影响，并与脑结构完整性和损伤并存的指标相关。