Genomics and Transgenics

同源菌株的开发仍然是缩短间隔和证明突变存在的最有力的工具。对于项目1，我们将间隔从13.2 Mb减少到<5 Mb，对于项目3，从2.5 Mb减少到< Mb，但仍保留血管生成表型。由于我们正在寻找捕获基因通路信息，除了项目1的基因识别，我们将研究更大的区域;而。项目3仅关注需要更精细分辨率的血管生成表型。

Development of congenic strains remains the most powerful tool to reduce an interval and demonstrate the mutation is present. For Project 1, we will reduce the interval from 13.2 Mb to <5Mb, and for Project 3 from 2.5 Mb to < Mb, yet to still retain the angiogenic phenotype. As we are looking to capture gene pathway information in addition to gene identification for Project 1, we will study a larger region; whereas. Project 3 is solely focused on the angiogenesis phenotype requires the finer resolution.