Tracking labor with uterine electrophysiological recordings and multi-scale model
利用子宫电生理记录和多尺度模型跟踪分娩
基本信息
- 批准号:8895047
- 负责人:
- 金额:$ 3.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-20 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAction PotentialsAdmission activityApplied ResearchArkansasAwardBirthCell modelCellsClinicalClinical ManagementClinical SciencesCollectionComplexContractsDevelopmentDevicesDiagnosisDiscipline of obstetricsEarly DiagnosisElectromagneticsElectrophysiology (science)EngineeringEnvironmentFetal DevelopmentFetal ResearchFetusFoundationsHealthHealthcare SystemsHospitalsHumanIndividualInduced LaborInterventionInvestigationKnowledgeLabor OnsetLength of StayLinkMagnetismMeasurementMedicalMethodologyMethodsModelingMorbidity - disease rateMothersMyometrialNational Institute of Child Health and Human DevelopmentNeurologicNewborn InfantOrganOutcomeOxytocinPatient SchedulesPatientsPerinatalPharmaceutical PreparationsPhysiciansPhysiologicalPhysiologyPregnancyPremature BirthPremature InfantPremature LaborProcessPropertyPseudopregnancyPublished CommentReportingResearch PersonnelScienceSignal TransductionSmooth MuscleSourceSystemTechniquesTherapeuticTherapeutic InterventionTimeTissuesTranslatingTranslational ResearchUnited StatesUnited States National Institutes of HealthUniversitiesUterine ContractionUterusWashingtonacronymsbasebehavior testclinical applicationcostdesigndosagefetalimprovedinnovationinstrumentmagnetic fieldmedical complicationmembermortalitymulti-scale modelingmultidisciplinarymyometriumpregnantpressurepreventreproductiverespiratorysensorsuccessful interventionsuperconducting quantum interference devicetooluterine smooth muscle cell
项目摘要
DESCRIPTION (provided by applicant): Preterm birth can cause severe health problems or even be fatal for the fetus, and, also imposes significant financial burdens on health care systems. Early and reliable diagnosis is essential to the development of successful interventions to prevent preterm delivery and improve outcome. In terms of physiology, the uterus is a complex organ, and at this time, our knowledge of the physiological mechanism of the onset and propagation of uterine contractions of labor remains incomplete. The uterus is normally able to accomplish the remarkable task of maintaining an environment which suppresses uterine contractile activity and is conducive to fetal development. At term gestation however, it initiates
and coordinates the individual firing of myometrial cells to produce organized contractions resulting in expulsion of the fetus. For poorly understood reasons, the onset of this coordinated activity can occur prior to term gestation with consequential birth of a premature infant. It is evident that the uterus undergoes electrophysiological changes leading to organized uterine contractions, thus providing the basis for the development of a methodology to accurately predict the onset of active labor. This proposal is a development of the combined efforts of a multidisciplinary team of members of the University of Arkansas for Medical Sciences (UAMS), University of Arkansas at Little Rock and Washington University St. Louis. All of these researchers have specialized knowledge in diverse fields of obstetrics, applied sciences and engineering relevant to the development of a synergetic environment. The need for such an effort is based on lack of tools in field of obstetrics for objective diagnosis of labor. UAMS has the world's first biomagnetic sensing system built specifically for fetal-maternal assessment. The SARA (SQUID Array for Reproductive Assessment) system consists of 151 primary superconducting sensors which detect biomagnetic fields generated in the body by various bioelectric sources including uterine muscles. The term "SQUID" is an acronym for "Superconducting Quantum Interference Device." The SARA system is completely non-invasive and permits the investigation of fetal and maternal parameters from early gestation until delivery. We have shown that SARA is capable of recording electrical activity of the uterine smooth muscles that can provide an electrophysiological signature of onset of labor. To transform it into a clinical tool we need to investigate how therapeutic interventions will alter te labor process. In order to accomplish this we propose to develop a multiscale forward electromagnetic model of contractile activity during pregnancy taking into account electrophysiological and anatomical knowledge. By combining macroscopic recordings with multi-scale modeling approach, we believe the model will not only provide a link to observed uterine electrophysiological signals but also provide useful therapeutic information for the clinical management of pregnancy.
描述(由申请人提供):早产可能会导致严重的健康问题,甚至对胎儿造成致命的影响,还会给医疗保健系统带来巨大的经济负担。早期和可靠的诊断对于制定成功的干预措施以预防早产和改善结局至关重要。在生理学方面,子宫是一个复杂的器官,目前我们对宫缩的发生和传播的生理机制的了解还不完全。子宫通常能够完成维护一个抑制子宫收缩活动并有利于胎儿发育的环境的显着任务。然而,在足月妊娠时,它会启动
并协调子宫肌层细胞的个体激发,产生有组织的收缩,导致胎儿被排出。由于鲜为人知的原因,这种协调活动的开始可能发生在足月妊娠之前,从而导致早产儿的出生。显然,子宫经历电生理变化导致有组织的子宫收缩,从而为开发准确预测活跃性分娩开始的方法学提供了基础。这项提案是由阿肯色大学医学科学分校(UAMS)、小石城阿肯色大学和圣路易斯华盛顿大学组成的多学科团队共同努力的结果。所有这些研究人员都拥有与协同环境发展相关的产科、应用科学和工程学等不同领域的专业知识。之所以需要这样的努力,是因为产科领域缺乏客观诊断分娩的工具。UAMS拥有世界上第一个专门为胎儿-母亲评估而建造的生物磁感应系统。SARA(用于生殖评估的鱿鱼阵列)系统由151个初级超导传感器组成,这些传感器探测由包括子宫肌肉在内的各种生物电源在体内产生的生物磁场。术语“SQUID”是“超导量子干涉装置”的首字母缩写。SARA系统是完全非侵入性的,允许调查从早期怀孕到分娩的胎儿和母体参数。我们已经证明,SARA能够记录子宫平滑肌的电活动,这可以提供分娩开始的电生理信号。为了将其转化为临床工具,我们需要研究治疗干预将如何改变产程。为了实现这一点,我们建议在考虑到电生理学和解剖学知识的情况下,建立妊娠期间收缩活动的多尺度正向电磁模型。通过将宏观记录与多尺度建模方法相结合,我们相信该模型不仅将提供与观察到的子宫电生理信号的联系,而且将为临床妊娠管理提供有用的治疗信息。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Estimating uterine source current during contractions using magnetomyography measurements.
- DOI:10.1371/journal.pone.0202184
- 发表时间:2018
- 期刊:
- 影响因子:3.7
- 作者:Zhang M;La Rosa PS;Eswaran H;Nehorai A
- 通讯作者:Nehorai A
Modeling Magnetomyograms of Uterine Contractions during Pregnancy Using a Multiscale Forward Electromagnetic Approach.
- DOI:10.1371/journal.pone.0152421
- 发表时间:2016
- 期刊:
- 影响因子:3.7
- 作者:Zhang M;Tidwell V;La Rosa PS;Wilson JD;Eswaran H;Nehorai A
- 通讯作者:Nehorai A
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Hari Eswaran其他文献
Hari Eswaran的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Hari Eswaran', 18)}}的其他基金
Development of low-cost optically pumped magnetometer system for fetal applications
开发用于胎儿应用的低成本光泵磁力计系统
- 批准号:
10589808 - 财政年份:2022
- 资助金额:
$ 3.62万 - 项目类别:
Development of low-cost optically pumped magnetometer system for fetal applications
开发用于胎儿应用的低成本光泵磁力计系统
- 批准号:
10467588 - 财政年份:2022
- 资助金额:
$ 3.62万 - 项目类别:
Magnetoencephalography based tracking of fetal neurodevelopment in diabetic pregnancies
基于脑磁图的糖尿病妊娠胎儿神经发育追踪
- 批准号:
10483127 - 财政年份:2021
- 资助金额:
$ 3.62万 - 项目类别:
Development of Analysis Tools to Enhance Magnetomyographic Assessment of Pelvic Floor Muscles
开发分析工具以增强盆底肌肉肌磁图评估
- 批准号:
10443695 - 财政年份:2021
- 资助金额:
$ 3.62万 - 项目类别:
Magnetoencephalography based tracking of fetal neurodevelopment in diabetic pregnancies
基于脑磁图的糖尿病妊娠胎儿神经发育追踪
- 批准号:
10318260 - 财政年份:2021
- 资助金额:
$ 3.62万 - 项目类别:
Development of Analysis Tools to Enhance Magnetomyographic Assessment of Pelvic Floor Muscles
开发分析工具以增强盆底肌肉肌磁图评估
- 批准号:
10626082 - 财政年份:2021
- 资助金额:
$ 3.62万 - 项目类别:
Tracking labor with uterine electrophysiological recordings and multi-scale model
利用子宫电生理记录和多尺度模型跟踪分娩
- 批准号:
8629972 - 财政年份:2013
- 资助金额:
$ 3.62万 - 项目类别:
Tracking labor with uterine electrophysiological recordings and multi-scale model
利用子宫电生理记录和多尺度模型跟踪分娩
- 批准号:
8735146 - 财政年份:2013
- 资助金额:
$ 3.62万 - 项目类别:
Development of Spatial-Temporal Analysis Tools for Uterine Biomagnetic Signals
子宫生物磁信号时空分析工具的开发
- 批准号:
7389099 - 财政年份:2007
- 资助金额:
$ 3.62万 - 项目类别:
Development of Analysis Tools to Enhance Fetal Neurological Assessment
开发分析工具以增强胎儿神经学评估
- 批准号:
8545845 - 财政年份:2007
- 资助金额:
$ 3.62万 - 项目类别:
相似海外基金
Kilohertz volumetric imaging of neuronal action potentials in awake behaving mice
清醒行为小鼠神经元动作电位的千赫兹体积成像
- 批准号:
10515267 - 财政年份:2022
- 资助金额:
$ 3.62万 - 项目类别:
Signal processing in horizontal cells of the mammalian retina – coding of visual information by calcium and sodium action potentials
哺乳动物视网膜水平细胞的信号处理 â 通过钙和钠动作电位编码视觉信息
- 批准号:
422915148 - 财政年份:2019
- 资助金额:
$ 3.62万 - 项目类别:
Research Grants
CAREER: Resolving action potentials and high-density neural signals from the surface of the brain
职业:解析来自大脑表面的动作电位和高密度神经信号
- 批准号:
1752274 - 财政年份:2018
- 资助金额:
$ 3.62万 - 项目类别:
Continuing Grant
Development of Nanosheet-Based Wireless Probes for Multi-Simultaneous Monitoring of Action Potentials and Neurotransmitters
开发基于纳米片的无线探针,用于同时监测动作电位和神经递质
- 批准号:
18H03539 - 财政年份:2018
- 资助金额:
$ 3.62万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Population Imaging of Action Potentials by Novel Two-Photon Microscopes and Genetically Encoded Voltage Indicators
通过新型双光子显微镜和基因编码电压指示器对动作电位进行群体成像
- 批准号:
9588470 - 财政年份:2018
- 资助金额:
$ 3.62万 - 项目类别:
Enhanced quantitative imaging of compound action potentials in multi-fascicular peripheral nerve with fast neural Electrical Impedance Tomography enabled by 3D multi-plane softening bioelectronics
通过 3D 多平面软化生物电子学实现快速神经电阻抗断层扫描,增强多束周围神经复合动作电位的定量成像
- 批准号:
10009724 - 财政年份:2018
- 资助金额:
$ 3.62万 - 项目类别:
Enhanced quantitative imaging of compound action potentials in multi-fascicular peripheral nerve with fast neural Electrical Impedance Tomography enabled by 3D multi-plane softening bioelectronics
通过 3D 多平面软化生物电子学实现快速神经电阻抗断层扫描,增强多束周围神经复合动作电位的定量成像
- 批准号:
10467225 - 财政年份:2018
- 资助金额:
$ 3.62万 - 项目类别:
Fast high-resolution deep photoacoustic tomography of action potentials in brains
大脑动作电位的快速高分辨率深度光声断层扫描
- 批准号:
9423398 - 财政年份:2017
- 资助金额:
$ 3.62万 - 项目类别:
NeuroGrid: a scalable system for large-scale recording of action potentials from the brain surface
NeuroGrid:用于大规模记录大脑表面动作电位的可扩展系统
- 批准号:
9357409 - 财政年份:2016
- 资助金额:
$ 3.62万 - 项目类别:
Noval regulatory mechanisms of axonal action potentials
轴突动作电位的新调节机制
- 批准号:
16K07006 - 财政年份:2016
- 资助金额:
$ 3.62万 - 项目类别:
Grant-in-Aid for Scientific Research (C)