Development of Spatial-Temporal Analysis Tools for Uterine Biomagnetic Signals

子宫生物磁信号时空分析工具的开发

• 批准号: 7389099
• 负责人: Hari Eswaran
• 金额: $ 29.62万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7389099
• 关键词: Abdomen; Address; Algorithms; Americas; Area; Arkansas; Basic Science; Biomedical Engineering; Birth; Brain; Cells; Clinical; Complex; Computer Analysis; Data; Data Collection; Development; Devices; Diagnosis; Diagnostic; Electrophysiology (science); Emotional; Environment; Family; Fetal Development; Fetal Heart; Fetus; Financial cost; Funding; Goals; Health; Heart; Hospitals; Incidence; Individual; Infant; Institutes; Invasive; Investigation; Knowledge; Labor Onset; Lead; Localized; Magnetism; Magnetoencephalography; Maps; Measures; Medical; Methodology; Methods; Modeling; Mothers; Myometrial; Neonatal Intensive Care; Neurologic; Newborn Infant; Pacemakers; Patients; Physiological; Pregnancy; Pregnant Uterus; Premature Birth; Premature Labor; Prematurity of fetus; Prevention program; Process; Protocols documentation; Purpose; Range; Research Personnel; Resolution; Risk; Science; Signal Transduction; Site; Smooth Muscle; Source; Squid; System; Techniques; Technology; Time; Universities; Uterine Contraction; Uterus; Validation; Week; Work; base; design; fetal; improved; instrument; instrumentation; magnetic field; medical complication; member; prevent; reproductive; respiratory; sensor; superconducting quantum interference device; tool

DESCRIPTION (provided by applicant): At University of Arkansas for Medical Sciences (UAMS) we have installed the world's first non-invasive biomagnetic sensing system that was specifically modified and designed to study various aspects of maternal-fetal health. This system can record the magnetic field corresponding to the electrical activity of uterine contraction and provide requisite spatial-temporal information. Our preliminary studies show that by recording uterine magnetomyographic (MMG) signals we can localize the area of activation over the uterus during a contraction. This allows us to explore the origin and propagation of uterine contraction despite the shifting of the pacemaker site from one contraction to another. We can localize the pacemaker by mapping the magnetic field distribution and quantify the spread by obtaining the percent of sensors active during each contraction with sensors spread over the entire maternal abdomen. To take advantage of the spatial-temporal resolution obtained by this instrument, we need to further enhance computational and analysis tools to develop it as a clinical device to predict the onset of labor both in the case of term and preterm patients. In this proposal our goal is to develop techniques to improve extraction, recognition and validation process of uterine magnetomyographic activity. By accomplishing this goal we can work towards achieving a comprehensive instrumentation and protocol that would aid in prediction of onset of labor. This ability would be of great clinical benefit for the management of the term patient and especially for the management of patients at high risk for premature delivery. We would like to advance the present state of development by first improving data collection and reliability of signal extraction. Then we want to develop techniques for verifying consistency of the signal so that data interpretation can proceed. The overall goals of the project include: (1) EXTRACTION and DETECTION: Improve methods for extraction and development of efficient separation algorithms for the spatial-temporal uterine MMG signals. (2) QUANTIFICATION: We propose to quantify the spatial and temporal parameters that could be would aid in prediction of the onset of labor. (3) CHARECTERIZATION: As a further step we plan to characterize the regions of activation, propagation velocity and direction, and the spread of activity as a function of distance.(4) MODELING: Develop a simple bidomain model and explore its relationship to MMG recordings. Relevance: An objective technique to predict the onset of labor in term and preterm patients would be of great clinical benefit to aid in management of pregnancies. Information gained can result in methods focusing on specific applications to prevent or control preterm labor thereby reducing the incidence of preterm birth.

描述（由申请人提供）：在阿肯色大学的医学科学大学（UAMS），我们安装了世界上第一个非侵入性生物磁传感系统，该系统经过专门修改并设计，旨在研究孕产妇健康的各个方面。该系统可以记录与子宫收缩的电活动相对应的磁场，并提供必要的时空信息。我们的初步研究表明，通过记录子宫录像学（MMG）信号，我们可以在收缩期间定位子宫上的激活区域。这使我们能够探索子宫收缩的起源和传播，尽管起搏器部位从一个收缩转移到另一个收缩。我们可以通过映射磁场分布并通过在每次收缩期间获得活跃的传感器的百分比与传感器分布在整个母体腹部上的传感器来定位起搏器。为了利用该仪器获得的时空分辨率，我们需要进一步增强计算和分析工具，以开发它作为临床手段，以预测术语和早产患者的劳动力。在此提案中，我们的目标是开发技术以改善子宫磁化学活动的提取，识别和验证过程。通过实现这一目标，我们可以致力于实现一项全面的仪器和协议，这将有助于预测劳动的发作。这种能力将对患者一词的管理，尤其是对高过早分娩风险高风险的患者的管理有很大的临床益处。我们希望通过首先提高数据收集和信号提取的可靠性来推动当前的发展状态。然后，我们想开发用于验证信号一致性的技术，以便可以进行数据解释。该项目的总体目标包括：（1）提取和检测：改进提取和开发时空子宫MMG信号的有效分离算法的方法。 （2）量化：我们建议量化可以有助于预测劳动发作的空间和时间参数。 （3）Charecterization：作为进一步的步骤，我们计划表征激活区域，传播速度和方向以及活动的传播作为距离的函数。（4）建模：开发一个简单的Bidomain模型并探索其与MMG记录的关系。相关性：一种预测学期和早产患者劳动力发作的客观技术将是有助于治疗怀孕的临床益处。获得的信息可能会导致侧重于预防或控制早产的特定应用，从而减少早产的发生率。