Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers

描述（由申请人提供）：我们的长期目标是增加女同性恋、男同性恋、双性恋和变性（LGBT）吸烟者的戒烟率，并了解这一服务不足人群中戒烟和复吸的相关过程。本研究分两个阶段进行，主要目的是比较文化目标干预与非目标干预对LGBT吸烟者戒烟结果的效果。进一步的目的是确定ALA-CT干预对个体介导的戒烟预测因子的影响，并探索ALA-CT干预对戒烟产生影响（差异或无差异）的潜在文化和社会心理机制。在第一阶段，我们将使用焦点小组和试点试验来确定干预目标元素的文化适宜性和可接受性。在第二阶段，我们将进行一项随机戒烟试验，首次比较美国肺脏协会“吸烟自由计划”（ALA-FFS）的疗效。针对LGBT吸烟者的文化目标（ALA-CT）和非目标（标准ALA-FFS）。ALA-CT将包括7个以文化为目标（社会心理和文化）的小组咨询会议，并结合尼古丁替代和同伴支持。对照条件是接受非靶向ALA-FFS计划、尼古丁替代和同伴支持的吸烟者。主要的戒烟结果将是点流行戒烟，即前7天不吸烟，甚至不吸一口烟，并将通过时间轴追踪衍生措施评估长期戒烟和点流行戒烟率。报告的结果将在随访1个月、3个月、6个月、9个月和12个月时客观验证[一氧化碳（CO）检测]，以确定短期和长期戒烟结果。我们将控制已知与吸烟结果相关的人口统计学变量。

DESCRIPTION (provided by applicant): Our long-term goals are to increase smoking cessation in lesbian, gay, bisexual and transgender (LGBT) smokers and to understand the processes related to cessation and relapse in this underserved population. Conducted in two phases, the primary aim of this study is to compare the efficacy of a culturally targeted intervention versus a non-targeted intervention on smoking cessation outcomes in LGBT smokers. Further aims are to determine the effect of the ALA-CT intervention on individually mediated predictors of cessation and to explore the underlying cultural and psychosocial mechanisms through which the ALA-CT intervention has an impact (differential or not) on smoking cessation. In Phase I, we will use focus groups and a pilot trial to establish the cultural appropriateness and acceptability of the targeted elements of the intervention. In Phase 2, we will conduct a randomized smoking cessation trial to compare for the first time the efficacy of the American Lung Association's 'Freedom from Smoking Program' (ALA-FFS). Culturally targeted (ALA-CT) and Non-Targeted (Standard ALA-FFS) to LGBT smokers. The ALA-CT will consist of 7 culturally targeted (psychosocial and cultural) group counseling sessions combined with nicotine replacement and peer support. The contrast condition will be smokers who receive the non-targeted ALA-FFS program, nicotine replacement and peer support. The primary smoking cessation outcome will be point prevalence abstinence, i.e., no smoking, not even a puff, for previous 7 days, and will be assessed by Timeline Follow-Back derived measures for prolonged abstinence and point prevalence quit rates. Reported outcomes will be objectively verified [Carbon monoxide (CO) testing] at 1 month, 3, 6, 9 and 12 months follow-up to determine short and longer- term cessation outcomes. We will control for demographic variables that have known associations with smoking outcomes.