Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers

描述（由申请人提供）：我们的长期目标是增加女同性恋，男同性恋，双性恋和变性人（LGBT）吸烟者的戒烟，并了解与戒烟和复吸相关的过程。本研究分两个阶段进行，主要目的是比较文化针对性干预与非针对性干预对LGBT吸烟者戒烟结果的有效性。进一步的目的是确定ALA-CT干预对个体介导的戒烟预测因子的影响，并探索ALA-CT干预对戒烟产生影响（差异或不影响）的潜在文化和心理社会机制。在第一阶段，我们将利用焦点小组和试点试验，以确定文化的适当性和接受的目标元素的干预。在第二阶段，我们将进行一项随机戒烟试验，首次比较美国肺脏协会的“戒烟自由计划”（ALA-FFS）的疗效。针对LGBT吸烟者的文化目标（ALA-CT）和非目标（标准ALA-FFS）。ALA-CT将包括7个有文化针对性的（心理社会和文化）团体咨询会议，结合尼古丁替代和同伴支持。对比条件将是接受非靶向ALA-FFS计划、尼古丁替代和同伴支持的吸烟者。主要的戒烟结果将是戒烟率，即，在过去7天内不吸烟，甚至不吸一口烟，并将通过时间轴随访衍生的长期戒烟和点患病率戒烟率的指标进行评估。将在1个月、3个月、6个月、9个月和12个月随访时对报告的结局进行客观验证[一氧化碳（CO）检测]，以确定短期和长期戒烟结局。我们将控制已知与吸烟结果相关的人口统计学变量。

DESCRIPTION (provided by applicant): Our long-term goals are to increase smoking cessation in lesbian, gay, bisexual and transgender (LGBT) smokers and to understand the processes related to cessation and relapse in this underserved population. Conducted in two phases, the primary aim of this study is to compare the efficacy of a culturally targeted intervention versus a non-targeted intervention on smoking cessation outcomes in LGBT smokers. Further aims are to determine the effect of the ALA-CT intervention on individually mediated predictors of cessation and to explore the underlying cultural and psychosocial mechanisms through which the ALA-CT intervention has an impact (differential or not) on smoking cessation. In Phase I, we will use focus groups and a pilot trial to establish the cultural appropriateness and acceptability of the targeted elements of the intervention. In Phase 2, we will conduct a randomized smoking cessation trial to compare for the first time the efficacy of the American Lung Association's 'Freedom from Smoking Program' (ALA-FFS). Culturally targeted (ALA-CT) and Non-Targeted (Standard ALA-FFS) to LGBT smokers. The ALA-CT will consist of 7 culturally targeted (psychosocial and cultural) group counseling sessions combined with nicotine replacement and peer support. The contrast condition will be smokers who receive the non-targeted ALA-FFS program, nicotine replacement and peer support. The primary smoking cessation outcome will be point prevalence abstinence, i.e., no smoking, not even a puff, for previous 7 days, and will be assessed by Timeline Follow-Back derived measures for prolonged abstinence and point prevalence quit rates. Reported outcomes will be objectively verified [Carbon monoxide (CO) testing] at 1 month, 3, 6, 9 and 12 months follow-up to determine short and longer- term cessation outcomes. We will control for demographic variables that have known associations with smoking outcomes.