Exhaled Biomarkers of Pulmonary Infection in the Critically Ill

项目摘要 候选人提议设立职业发展独立之路奖，以进一步发展研究 具备生物行为临床研究领域的技能。该提案的每一个目标都得到了说教的支持 课程工作、研究培训经验、科学会议和研讨会，包括详细的传播 计划。候选人的最终职业目标是成为一名专注于改善护理的独立科学家 以及机械通气危重病人的转归。呼吸机相关性肺炎(VAP)是一种急性 护理并发症，发病率和死亡率高，增加了住院时间和卫生保健资源 使用。拟议的K99研究项目的目的是评估呼出的生物标志物和护理 影响机械通气人群肺部感染的因素分析 机械通风的危重病人。其主要目的是评估呼气障碍的关系。 危重MV患者的生物标志物、系统生物标志物与肺部感染。第二个目标是 检查这些患者的护理因素(体位和肺部卫生)及其关系 在这些因素和呼气成分、呼气生物标志物和肺部感染之间。电浆 将从气管插管的成人身上收集呼气样本进行生物标志物分析 将评估其与肺部感染评分的一致性和关联性。此外，护理 将收集和评估护理因素(定位和肺部卫生)数据，以便与 呼出的生物标志物和肺部感染评分。这项研究提案的总体目标是提供 具有生物标记物分析基础和护理因素知识的候选人 与肺部感染相关并推进候选人的研究计划，旨在改善 危重病患者的肺健康结局。此外，通过了解护士指导的护理的效果 关于呼气生物标志物与机械通气患者肺部感染的关系，本研究将提供 对这些疗法的病理意义的基础性见解，并可能在未来的临床上产生 相关研究假设。

Project Summary The candidate proposes a career development Pathways to Independence award to further develop research skills in the area of biobehavioral clinical research. Each aim of the proposal is supported by didactic coursework, research training experiences, scientific meetings and seminars including a detailed dissemination plan. The candidate's ultimate career goal is to become an independent scientist focused on improving care and outcomes of the mechanically ventilated critically ill. Ventilator-associated pneumonia (VAP) is an acute care complication with high morbidity and mortality, which increases length of stay and health care resources used. The purpose of the proposed K99 research project is to evaluate exhaled biomarkers and nursing care factors in the mechanically ventilated population to obtain a better understanding of pulmonary infection in the mechanically ventilated critically ill population. The primary aim is to evaluate relationships of exhaled biomarkers, systemic biomarkers and pulmonary infection in critically ill MV patients. The secondary aim is to examine nursing care factors (positioning and pulmonary hygiene) in these patients and the relationship between those factors and exhaled breath composition, exhaled biomarkers and pulmonary infection. Plasma and exhaled breath samples will be collected from endotracheally intubated adults for biomarker analysis which will be assessed for agreement and association with pulmonary infection scores. Additionally, nursing care factor (positioning and pulmonary hygiene) data will be collected and assessed for association with exhaled biomarkers and pulmonary infections scores. The overall goal of this research proposal is to provide the candidate with a foundation in biomarker analysis and knowledge of nursing care factors that are associated with pulmonary infection and advance the candidate's research program aimed at improving pulmonary health outcomes of the critically ill. Additionally, by understanding the effect of nurse-directed care on exhaled biomarkers and pulmonary infection in mechanically ventilated patients, this study will provide foundational insight into the pathological significance of these therapies and may generate future clinically relevant research hypotheses.