A genetic screen for modulators of nociception
伤害感受调节剂的基因筛选
基本信息
- 批准号:8670722
- 负责人:
- 金额:$ 37.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-06-05 至 2018-05-31
- 项目状态:已结题
- 来源:
- 关键词:Acute PainAddressAdverse effectsAffectAnimal ModelBehaviorBehavioralBiological AssayBiological ModelsCandidate Disease GeneChemicalsChronicCodeCommunitiesDataDevelopmentEconomic BurdenEmotionalEsthesiaFaceGene CombinationsGene ExpressionGene MutationGenesGeneticGenetic DeterminismGenetic ScreeningHeatingImageryIndividualInjuryIrritantsLarvaLocomotionMapsMeasuresMechanicsMedicalMembraneModalityMolecularMusMutationNervous system structureNeuronsNociceptionNociceptive StimulusNociceptorsOrganismPainPatternPerceptionPeripheralPersistent painPharmaceutical PreparationsPhenocopyPhenotypePlayPopulationPositioning AttributeProductivityPropertyResearchResourcesRoleSocietiesSpecificityStimulusStructure of trigeminal ganglionSymptomsSystemTestingTimeTissuesTouch sensationTransgenic OrganismsTrigeminal SystemUnited StatesWagesZebrafishaddictionbasebehavior testcalcium indicatorchronic painhomologous recombinationin vivoinnovationinterestmustard oilmutantneural circuitneuron developmentnovelpromoterpublic health relevanceresponsesensorsomatosensorytool
项目摘要
DESCRIPTION (provided by applicant): Our research is focused on revealing the molecular mechanisms that underlie the perception of pain. Sensation of painful stimuli is critical for the survival of the organism. However, acute and chronic pain affects hundreds of millions of people as a result of injury, and is a major symptom in many illnesses. Unfortunately, currently available drug based therapies have numerous deleterious side effects and/or potential for abuse and addiction, while also not being effective in the treatment of persistent pain. Despite great advances, much remains to be understood about how painful or noxious stimuli are perceived and coded by the nervous system. Here we propose to use the zebrafish system to conduct a forward genetic screen to elucidate the fundamental properties of the neural circuits required for the sensation of pain. We have developed specific transgenic tools to examine the development and function of specific neuronal populations that detect modality specific nociceptive stimuli. We propose to use these tools to characterize genetic mutations that alter the behavioral response to heat, cold, mechanical or chemical irritants. Our preliminary data demonstrate that we can identify mutations affecting distinct pain modalities. We expect that this genetic screen will provide a resource for the community interested in the development of neural circuits and the perception of pain, and may provide targets for potential therapies for debilitating painful conditions.
描述(由申请人提供):我们的研究重点是揭示疼痛感知的分子机制。疼痛刺激的感觉对于有机体的生存至关重要。然而,急性和慢性疼痛影响数亿人的伤害,是许多疾病的主要症状。不幸的是,目前可用的基于药物的疗法具有许多有害的副作用和/或滥用和成瘾的可能性,同时在治疗持续性疼痛中也无效。尽管取得了巨大的进步,但关于神经系统如何感知和编码疼痛或有害刺激,仍有许多问题需要了解。在这里,我们建议使用斑马鱼系统进行正向遗传筛选,以阐明疼痛感觉所需的神经回路的基本特性。我们已经开发了特定的转基因工具来检查特定神经元群体的发育和功能,这些神经元群体检测特定的伤害性刺激。我们建议使用这些工具来表征改变对热、冷、机械或化学刺激物的行为反应的基因突变。我们的初步数据表明,我们可以识别影响不同疼痛模式的突变。我们希望这种遗传筛选将为对神经回路的发展和疼痛感知感兴趣的社区提供资源,并可能为衰弱性疼痛疾病的潜在治疗提供目标。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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AJAY K DHAKA其他文献
AJAY K DHAKA的其他文献
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{{ truncateString('AJAY K DHAKA', 18)}}的其他基金
Identifying new targets in pain, utilizing the novel analgesic AS1
利用新型镇痛药 AS1 确定疼痛的新靶点
- 批准号:
10307581 - 财政年份:2020
- 资助金额:
$ 37.68万 - 项目类别:
Identifying new targets in pain, utilizing the novel analgesic AS1
利用新型镇痛药 AS1 确定疼痛的新靶点
- 批准号:
10547775 - 财政年份:2020
- 资助金额:
$ 37.68万 - 项目类别:
Identifying new targets in pain, utilizing the novel analgesic AS1
利用新型镇痛药 AS1 确定疼痛的新靶点
- 批准号:
10117446 - 财政年份:2020
- 资助金额:
$ 37.68万 - 项目类别:
A Highthroughput Targeted Genetic Screen for Modulators of Nociception
伤害感受调节剂的高通量靶向遗传筛选
- 批准号:
9582710 - 财政年份:2018
- 资助金额:
$ 37.68万 - 项目类别:
An unbiased highthroughput behavior based screen for small molecule analgesics
基于无偏倚高通量行为的小分子镇痛药筛选
- 批准号:
9241451 - 财政年份:2016
- 资助金额:
$ 37.68万 - 项目类别:
An unbiased highthroughput behavior based screen for small molecule analgesics
基于无偏倚高通量行为的小分子镇痛药筛选
- 批准号:
9090664 - 财政年份:2016
- 资助金额:
$ 37.68万 - 项目类别:
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