Acute HCV infection in Rio de Janeiro

多年来，急性丙型肝炎病毒感染的识别一直是一个重大挑战，因为它是自然的 病程通常是静默的，没有症状。全世界都在进行合作努力，以 识别新病例，因为它们提供了有关病毒和宿主相互作用的相关信息。这个继续进行的项目 已经确认了77例急性丙型肝炎病毒感染；其中大多数是有症状的(80%)，而且有风险 在医疗环境中主要是医院因素，其次是性传播。自发清除 有54%的人被记录在案。大多数病例是由于单一接触造成的，因为没有报道称 静脉注射毒品。即使患者早在3点就被转诊到肝炎治疗中心 几个月来，许多患者在急性期没有得到治疗，令人惊讶的是，我们能够 少数观察到延迟自发清除。受试者对研究的坚持性和结果 在近9年的时间里，通过对患者的随访获得了 顺序性和连续性银行标本。这项研究不仅有助于在丙型肝炎早期阶段识别丙型肝炎病毒 但也为进一步研究猪瘟的免疫发病机制提供了受限的长FIME系列样本 成功的免疫治疗干预和疫苗的未来发展。

The identification of acute HCV infection has been a major challenge throughout the years as its natural course is usually silent and asymptomatic. Collaborative efforts are being made throughout the worid to recognize new cases as they offer relevant information on viral and host interactions. This continued project has already identified 77 cases of acute HCV infection; most of which were symptomatic (80%), and with risk factors being mainly nosocomial in medical settings followed by sexual transmission. Spontaneous clearance was documented in 54%. and most cases were due to a single exposure as there were no reports of intravenous drug use. Even though patients were referred to hepatitis treatment centers as eariy as 3 months, a number of patients were not treated during the acute phase, and we were, surprisingly able to observe delayed spontaneous clearance in a few. Subjects adhered highly to the study and results have been obtained through a follow-up of pafients during a course of almost 9 years, with a high yield of sequenfial and serial bank specimens. This study will not only help identify HCV in the eariy phase of infecfion but also offer confinued long fime serial samples for further studies on immune pathogenesis for future development of successful immunotherapeutic intervenfions and vaccines.