Interplay between metabolic reprogramming and oncogenic signalling in the cellular response to chemotherapy
Interplay between metabolic reprogramming and oncogenic signalling in the cellular response to chemotherapy
细胞化疗反应中代谢重编程与致癌信号之间的相互作用
批准号：
nhmrc : 1146642
负责人：
金额：
$43.61万
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2018
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2018-01-01 至 2020-12-31
中文摘要
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英文摘要
Chemotherapy resistance is a major barrier to the treatment of triple-negative breast cancer (TNBC). We seek to uncover an intimate link between cell metabolism and oncogenic signalling pathways in regulating the cellular response to chemotherapy. Our studies will identify a critical mechanism limiting the therapeutic efficacy of chemotherapy and investigate combination therapy strategies that could improve the treatment of TNBC.
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