Interplay between metabolic reprogramming and oncogenic signalling in the cellular response to chemotherapy

细胞化疗反应中代谢重编程与致癌信号之间的相互作用

• 批准号: nhmrc : GNT1146642
• 负责人: Dr Kristin Brown
• 金额: $ 64.5万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interplay-metabolic-reprogramming-response-chemotherapy/1348776
• 关键词: Interplay; between; metabolic; reprogramming; oncogenic

Chemotherapy resistance is a major barrier to the treatment of triple-negative breast cancer (TNBC). We seek to uncover an intimate link between cell metabolism and oncogenic signalling pathways in regulating the cellular response to chemotherapy. Our studies will identify a critical mechanism limiting the therapeutic efficacy of chemotherapy and investigate combination therapy strategies that could improve the treatment of TNBC.

化疗耐药性是三阴性乳腺癌（TNBC）治疗的主要障碍。我们试图揭示细胞代谢和致癌信号通路之间的密切联系，在调节细胞对化疗的反应。我们的研究将确定限制化疗疗效的关键机制，并研究可以改善TNBC治疗的联合治疗策略。