Research in the Pathogenesis of Hematologic Disorders

摘要 纽约大学医学院在培训学术血液学家方面有着悠久的记录。 这一记录在很大程度上是由1962年以来国家卫生研究院培训补助金的持续支持创造的 (T32)，支持6名医学博士、医学博士、博士和博士实习生。培训计划的长期目标是 为血液学实习生在学术医学领域的未来职业生涯做好准备。医学博士、医学博士和医学博士/ 统一培训计划中的博士和博士实习生有助于增加医生和 科学家致力于研究事业。培训计划让学员接受严格的指导 以实验室为基础的血液学研究，详细的课程，系列研讨会，期刊俱乐部，临床管理 会议，以及参加(医学博士实习生)或观察(博士实习生)的机会 与受训人员实验室检查相关的临床血液学。学员是从ACGME中挑选出来的 经认可的成人和儿科血液学/内科肿瘤学奖学金计划以及符合条件的职位- 参与教员实验室的博士生研究员。该计划由一名主任领导，有三个 高素质的副董事，专门致力于积极招聘代表性不足的少数族裔。 我们的15位导师具有指导经验和记录的工作效率，他们的实验室高度重视 互动并使用各种模型系统来研究1)良性血液学，包括PNH、血小板生物学 和Fanconi贫血；2)白血病的遗传学；3)JAK/STAT和RAS信号机制 造血干细胞、淋巴管、白血病和淋巴瘤；4)淋巴管生成和淋巴细胞活化 (包括GVHD)；5)髓系和淋巴系运输的机制；6)造血干细胞的泛素化 细胞生物学、淋巴细胞学和白血病/淋巴瘤；以及7)正常和非白血病的表观遗传学和分子基础。 异常的造血功能。我们过去的毕业生在学术界取得了最高级别的成就 在血液学领域做出了持久的贡献，我们新近毕业的学生中有很高比例 留在学术界，利用作为实习生获得的研究技能在研究人员的职业生涯中 教师和试用者。在过去的10年里，我们的大多数毕业生都在 学术机构，在最高级别的期刊上发表了他们的研究成果，并收到了多个 NIH和基金会奖。

Abstract The New York University School of Medicine has a long established record of training academic hematologists. In large part, this record has been fostered by the continuous support, since 1962, of a NIH Training Grant (T32) which supports 6 M.D., M.D., PhD, and PhD Trainees. The long term goal of the Training Program is to prepare Hematology Trainees for future careers in academic medicine. The interaction of both M.D., M.D./ PhD, and PhD Trainees in a unified Training Program serves to increase the number of physicians and scientists committed to a career in research. The Training Program exposes Trainees to rigorous mentored lab based hematology research, a detailed curriculum, seminar series, a journal club,a clinical management conference, and the opportunity to participate (for M.D Trainees) or observe (for PhD Trainees) the practice of clinical hematology relevant to the Trainee's laboratory investigation. Trainees are selected from the ACGME accredited adult and pediatric hematology/medical oncology fellowship programs and from eligible post- doctoral PhD fellows in participating faculty member's laboratories. The program, led by a Director with three well qualified Associate Directors, is specifically dedicated to actively recruiting underrepresented minorities. Our 15 Mentors have experience in mentoring and documented productivity, and their laboratories are highly interactive and use a variety of model systems to study 1) benign hematology including PNH, platelet biology and Fanconi anemia; 2) the genetics of leukemia; 3) JAK/STAT and Ras signaling mechanisms in hematopoietic stem cells, lymphopoieis, leukemia and lymphoma; 4) lymphopoiesis and lymphocyte activation (including GVHD); 5) mechanisms of myeloid and lymphoid trafficking; 6) ubiquitination in hematopoietic stem cell biology, lymphopoiesis, and leukemia/lymphoma; and 7) the epigenetic and molecular basis of normal and abnormal hematopoiesis. Past graduates of our program have achieved the highest ranks of academia and have made lasting contributions to the field of hematology, and a high proportion of our recent graduates remain in academia, using the research skills gained as Trainees in careers as researchers, academic teachers and trialists. Over the last 10 years the majority of our graduates have obtained positions in academic institutions, have published their findings in the highest tier of journals, and have received multiple NIH and foundation awards.