Research in the Pathogenesis of Hematologic Disorders

描述（由申请人提供）：纽约大学医学院在培养学术血液学家方面有着悠久的历史。在很大程度上，这一记录是由持续的支持，自1962年以来，美国国立卫生研究院培训补助金（T32），支持6医学博士，医学博士，PhD和PhD实习生培训计划的长期目标是为血液学实习生未来的学术医学职业做好准备。医学博士，医学博士/博士和博士培训生在一个统一的培训计划有助于增加致力于研究事业的医生和科学家的数量。培训计划使学员接触严格的基于实验室的血液学研究，详细的课程，系列研讨会，期刊俱乐部，临床管理会议，并有机会参与（医学博士学员）或观察（博士学员）与学员实验室研究相关的临床血液学实践。受训人员从ACGME认可的成人和儿童血液学/医学肿瘤学奖学金计划和参与教师实验室的合格博士后博士研究员中挑选。该计划由一名主任和三名合格的副主任领导，专门致力于积极招募代表性不足的少数民族。我们的15位导师具有指导经验和记录的生产力，他们的实验室高度互动，并使用各种模型系统研究1）良性血液学，包括PNH，血小板生物学和范可尼贫血; 2）白血病的遗传学; 3）造血干细胞，淋巴细胞生成，白血病和淋巴瘤中的JAK/STAT和Ras信号传导机制; 4）淋巴细胞生成和淋巴细胞活化（包括GVHD）; 5）骨髓和淋巴运输的机制; 6）造血干细胞生物学、淋巴细胞生成和白血病/淋巴瘤中的泛素化;以及7）正常和异常造血的表观遗传和分子基础。我们计划的过去的毕业生已经取得了学术界的最高排名，并为血液学领域做出了持久的贡献，我们最近的毕业生中有很大一部分仍然留在学术界，使用作为研究人员，学术教师和试验者职业培训生获得的研究技能。在过去的10年中，我们的大多数毕业生都在学术机构获得了职位，在最高级别的期刊上发表了他们的研究结果，并获得了多个NIH和基金会奖项。

DESCRIPTION (provided by applicant): The New York University School of Medicine has a long established record of training academic hematologists. In large part, this record has been fostered by the continuous support, since 1962, of a NIH Training Grant (T32) which supports 6 M.D., M.D., PhD, and PhD Trainees. The long term goal of the Training Program is to prepare Hematology Trainees for future careers in academic medicine. The interaction of both M.D., M.D./PhD, and PhD Trainees in a unified Training Program serves to increase the number of physicians and scientists committed to a career in research. The Training Program exposes Trainees to rigorous mentored lab based hematology research, a detailed curriculum, seminar series, a journal club, a clinical management conference, and the opportunity to participate (for M.D Trainees) or observe (for PhD Trainees) the practice of clinical hematology relevant to the Trainee's laboratory investigation. Trainees are selected from the ACGME accredited adult and pediatric hematology/medical oncology fellowship programs and from eligible post- doctoral PhD fellows in participating faculty member's laboratories. The program, led by a Director with three well qualified Associate Directors, is specifically dedicated to actively recruiting underrepresented minorities. Our 15 Mentors have experience in mentoring and documented productivity, and their laboratories are highly interactive and use a variety of model systems to study 1) benign hematology including PNH, platelet biology and Fanconi anemia; 2) the genetics of leukemia; 3) JAK/STAT and Ras signaling mechanisms in hematopoietic stem cells, lymphopoieis, leukemia and lymphoma; 4) lymphopoiesis and lymphocyte activation (including GVHD); 5) mechanisms of myeloid and lymphoid trafficking; 6) ubiquitination in hematopoietic stem cell biology, lymphopoiesis, and leukemia/lymphoma; and 7) the epigenetic and molecular basis of normal and abnormal hematopoiesis. Past graduates of our program have achieved the highest ranks of academia and have made lasting contributions to the field of hematology, and a high proportion of our recent graduates remain in academia, using the research skills gained as Trainees in careers as researchers, academic teachers and trialists. Over the last 10 years the majority of our graduates have obtained positions in academic institutions, have published their findings in the highest tier of journals, and have received multiple NIH and foundation awards.