Antecedents and Consequences of Cocaine Taking: Impact of Oxytocin
Antecedents and Consequences of Cocaine Taking: Impact of Oxytocin
批准号:
9747260
负责人:
Suzette M Evans
金额:
$57.9万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-01 至 2023-05-31
关键词:
AccountingAcuteAffectAggressive behaviorAmphetaminesAnimalsBehaviorBehavioralBiologic DevelopmentBiologicalCocaineCorpus striatum structureDataData SetDesire for foodDopamineDrug usageEstrogensFemaleFoodGroomingHippocampus (Brain)IntakeIntravenousLuteal PhaseMacaca fascicularisMacaca mulattaMeasuresMediatingMenstrual cycleMonkeysOxytocinPalatePeripheralPharmaceutical PreparationsPhysiologyPrimatesProgesteroneProspective StudiesRattusResearchRisk FactorsRunningSame-sexSelf AdministrationSex DifferencesSocial BehaviorSocial statusStandardizationStructureSystemTestingbasebehavioral responsecohortdiketopiperazinedrug of abuseindexingmaleneurogenesisnonhuman primatepeptide hormoneproliferative phase Menstrual cycleprospectivereinforcerrelating to nervous systemresponsesexsocialsocial attachmentsocial structurestandard measuretrait
中文摘要
灵长类动物的支配行为和社会地位影响着生理、神经结构、行为和反应
滥用药物。催产素(OXT)是一种与支配行为相关的肽激素,可调节可卡因
自我给药并与海马(HC)体积相关。男性统治通常依赖于
而女性的统治通常依赖于梳理。我们假设不同的行为
与男性和女性的社会结构有关的因素解释了可卡因自我给药的性别差异
在群居食蟹猴中观察到。因此,支配行为和性别都是适度的药物,
然而,关于这两个变量相互作用的研究却严重缺失。我们假设
优势行为是一个重要的因素,占生物相关的变异性研究与非-
人类灵长类动物因此,我们提出了一个前瞻性研究的影响,性别,月经周期,优势,
行为和可卡因自我给药对恒河猴OXT水平和HC体积的影响以及
在可卡因自我给药时操纵OXT我们将使用标准化的同性配对互动测试,
获得每只猴子的优势指数。我们的初步数据显示,即使在
单独圈养的非人类灵长类动物,与纹状体多巴胺的释放,可卡因的强化作用,
安非他明的食欲和HC的量因此,优势指数是一个相关的措施,
与社会和非社会行为者有关的行为特征。目标1.决定支配地位的影响-
雄性(n = 10)和雌性(n = 10)恒河猴HC体积和OXT水平的指数。目标2a。确定
自我管理的静脉注射可卡因和可口的食物作为优势指数的函数的强化作用。
目标2b。确定月经周期和优势指数对自我强化效应的影响,
静脉注射可卡因和可口的食物目标3:确定(9个月)可卡因自身的影响,
施用对HC体积和OXT水平的影响作为优势指数的函数。目标4。确定
a)通过急性施用SOC 1增加OXT水平的作用,由Iain MacGregor开发,B)
通过急性施用OXT拮抗剂2,5-二酮哌嗪(DTP)降低OXT效应,和c)
SOC1 + DTP对可卡因自我给药的影响作为优势指数的函数。
冲击我们将动态和前瞻性地跟踪雄性和雌性恒河猴的HC体积和OXT水平
为了评估这些措施在多大程度上是吸毒的风险因素,
吸毒,或者两者兼而有之。通过使用自然变化的优势指数,我们将能够梳理出
环境因素造成的。这一建议将提供一个经验基础,
开发催产素系统的生物信息操纵,以及行为信息操纵。
根据男性和女性的社会行为进行治疗。
英文摘要
Dominance behaviors and social status in primates affects physiology, neural structure, behavior and response
to drugs of abuse. Oxytocin (OXT), a peptide hormone associated with dominance behavior modulates cocaine
self-administration and is associated with hippocampal (HC) volume. Male dominance commonly relies on
aggression while female dominance commonly relies on grooming. We hypothesize that the different behaviors
associated with male and female social structure account for the sex differences in cocaine self-administration
observed in socially-housed cynomolgus monkeys. Thus, both dominance behavior and sex moderate drug
response, yet studies on the interaction of these two variables are sorely missing. We hypothesize that
dominance behavior is a significant factor accounting for biologically relevant variability in research with non-
human primates. Therefore, we propose a prospective study on the effects of sex, menstrual cycle, dominance
behavior and cocaine self-administration on OXT levels and HC volume in rhesus monkeys and the effects of
manipulating OXT on cocaine self-administration. We will use standardized, same-sex dyad-interaction tests to
obtain a dominance-index for each monkey. Our preliminary data show that the dominance-index, even in
singly-housed non-human primates, is related to striatal dopamine release, the reinforcing effects of cocaine,
the appetitive effects of amphetamine, and HC volume. Thus the dominance-index is a relevant measure of a
behavioral trait related to both social and non-social reinforcers. Aim 1. Determine the effect of dominance-
index on HC volume and OXT levels in male (n = 10) and female (n = 10) rhesus monkeys. Aim 2a. Determine
the reinforcing effects of self-administered i.v. cocaine and palatable food as a function of dominance-index.
Aim 2b. Determine the effects of menstrual cycle and dominance-index on the reinforcing effects of self-
administered i.v. cocaine and palatable food. Aim 3. Determine the effects of (9 mo) cocaine self-
administration on HC volume and OXT levels as a function of the dominance-index. Aim 4. Determine the
effects of a) increasing OXT levels by acute administration of SOC1, developed by Iain MacGregor, b)
decreasing OXT effects by acute administration of the OXT antagonist 2,5- diketopiperazine (DTP) and c)
SOC1 + DTP on cocaine self-administration as a function of the dominance-index.
Impact. We will dynamically and prospectively track HC volume and OXT levels in male and female rhesus
monkeys in order to assess the extent to which these measures are risk factors for drug use, consequences of
drug use, or both. By using naturally varying dominance-indexes, we will be able to tease out the effects of
environmental conditions from cocaine taking. This proposal will provide an empirical basis for the
development of biologically-informed manipulations of the oxytocin system, and behaviorally-informed
treatments based on social behavior for both males and females.
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会议论文
Antecedents and Consequences of Cocaine Taking: Impact of Oxytocin
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批准号:10408141
-
项目类别:
-
资助金额:$62.02万
-
财政年份:2017
-
负责人:Suzette M Evans
-
依托单位:
Antecedents and Consequences of Cocaine Taking: Impact of Oxytocin
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批准号:9239086
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项目类别:
-
资助金额:$68.0万
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财政年份:2017
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负责人:Suzette M Evans
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依托单位:
Antecedents and Consequences of Cocaine Taking: Impact of Oxytocin
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批准号:10163826
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项目类别:
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资助金额:$62.09万
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财政年份:2017
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负责人:Suzette M Evans
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Preclinical Synthetic Cannabinoid Vapor Inhalation: Acute and Chronic Effects
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批准号:9056567
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项目类别:
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资助金额:$71.77万
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财政年份:2015
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依托单位:
Stress-Induced Marijuana Self-Administration: Role of Sex and Oxytocin
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批准号:8561004
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资助金额:$50.47万
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财政年份:2013
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Stress-Induced Marijuana Self-Administration: Role of Sex and Oxytocin
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批准号:8992903
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财政年份:2013
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依托单位:
Sex Differences in Stress & Impulsivity in Cocaine Abusers
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批准号:7479677
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项目类别:
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资助金额:$47.88万
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财政年份:2007
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负责人:Suzette M Evans
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依托单位:
Progesterone Treatment for Cocaine-Dependent Women
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批准号:7632295
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项目类别:
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资助金额:$35.58万
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财政年份:2007
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负责人:Suzette M Evans
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依托单位:
Sex Differences in Stress & Impulsivity in Cocaine Abusers
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批准号:7660476
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项目类别:
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资助金额:$50.74万
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财政年份:2007
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负责人:Suzette M Evans
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依托单位:
Progesterone Treatment for Cocaine-Dependent Women
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批准号:7173222
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项目类别:
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资助金额:$35.58万
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财政年份:2007
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负责人:Suzette M Evans
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依托单位:
Progesterone Treatment for Cocaine-Dependent Women
-
批准号:7493106
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项目类别:
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资助金额:$35.22万
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财政年份:2007
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负责人:Suzette M Evans
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依托单位:
Sex Differences in Stress & Impulsivity in Cocaine Abusers
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批准号:7316703
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项目类别:
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资助金额:$49.68万
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财政年份:2007
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负责人:Suzette M Evans
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依托单位:
Sex Differences in Stress & Impulsivity in Cocaine Abusers
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批准号:7903464
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项目类别:
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资助金额:$50.0万
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财政年份:2007
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负责人:Suzette M Evans
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依托单位:
Effects of Smoked Heroin Across the Menstrual Cycle
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批准号:6943542
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资助金额:$27.92万
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财政年份:2003
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负责人:Suzette M Evans
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依托单位:
Effects of Smoked Heroin Across the Menstrual Cycle
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批准号:6806577
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项目类别:
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资助金额:$27.63万
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财政年份:2003
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负责人:Suzette M Evans
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依托单位:
Effects of Smoked Heroin Across the Menstrual Cycle
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批准号:6676428
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资助金额:$29.84万
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财政年份:2003
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依托单位:
COCAINE'S EFFECTS ACROSS THE MENSTRUAL CYCLE
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批准号:6515708
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项目类别:
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资助金额:$26.64万
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财政年份:2000
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依托单位:
COCAINE'S EFFECTS ACROSS THE MENSTRUAL CYCLE
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批准号:6634275
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项目类别:
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资助金额:$26.64万
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财政年份:2000
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负责人:Suzette M Evans
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依托单位:
COCAINE'S EFFECTS ACROSS THE MENSTRUAL CYCLE
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批准号:6775665
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项目类别:
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资助金额:$26.64万
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财政年份:2000
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负责人:Suzette M Evans
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依托单位:
COCAINE'S EFFECTS ACROSS THE MENSTRUAL CYCLE
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批准号:6378920
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项目类别:
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资助金额:$26.64万
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财政年份:2000
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负责人:Suzette M Evans
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依托单位:
海外基金