Epidemiology and Outcomes of Premature Geriatrics Syndromes

描述(由申请人提供)：这是为丽贝卡·布朗博士重新提交的以患者为导向的研究生涯发展奖的重新提交申请。布朗博士的长期目标是成为老龄化研究的领导者，以改善社会经济上处于不利地位的老年人的健康和功能状况，包括那些患有早发性(早产儿)老年综合征的人。这一奖项将通过在几个关键领域获得额外的培训并完成拟议的指导性研究项目，为布朗博士提供必要的支持，使她继续朝着这一目标前进。拟议的职业奖项解决了一个关键的知识缺口：在65岁以下的成年人中发展的老年综合征的流行病学和结果。虽然众所周知，一些成年人在大多数成年人保持身体健康的年龄出现衰老表型，但对这些人的流行病学、结果和潜在的管理策略知之甚少。Brown博士提出的职业发展计划将使她能够通过与一支优秀的导师团队合作来解决这一知识差距，他们将监督以下三个培训目标：(1)在临床研究方法和内容领域获得专业知识，这些领域对她作为独立临床医生研究员的未来成功至关重要(辅助数据分析的先进方法、临床试验的设计、实施和分析方法、健康的社会决定因素以及定性研究)；(2)在加州大学旧金山分校和全国建立关键的发展网络；以及(3)发展拨款和研究管理技能和经验。布朗博士将在她的指导团队的密切指导和支持下，通过实施拟议的研究项目来实现这些目标。此外，她的培训将得到高价值的教学课程、教程和研讨会的支持。她从这次培训中获得的技能和经验将为她成为一名独立的调查员做好准备，并成功地申请R01补助金，实施一项旨在识别和管理过早老年综合征的干预措施。布朗博士的研究将描述过早老年综合征的流行病学和风险因素(目标1)，并将确定过早老年综合征与不良后果之间的关系，包括住院、住院和死亡率(目标2)。布朗博士将使用具有全国代表性的健康和退休研究的纵向数据来实现目标1和目标2。然后，她将进行一项定性研究，以更好地了解患者和临床医生对早产老年综合征患者的临床需求的看法，并确定可能有助于满足这些需求的护理模式(目标3)。

DESCRIPTION (provided by applicant): This is a Resubmission Application for a Mentored Patient-Oriented Research Career Development Award for Dr. Rebecca Brown. Dr. Brown's long-term goal is to become a leader in aging research to improve the health and functional status of socioeconomically disadvantaged older adults, including those with early- onset (premature) geriatric syndromes. This award will provide Dr. Brown with the support necessary to continue her progress towards this goal, by obtaining additional training in several key areas and by completing the proposed mentored research project. The proposed career award addresses a critical knowledge gap: the epidemiology and outcomes of geriatric syndromes that develop in adults younger than age 65. Although it is well-recognized that some adults develop aging phenotypes at an age when most adults remain physically robust, very little is known about the epidemiology, outcomes, and potential management strategies of these individuals. Dr. Brown's proposed career development plan will allow her to address this knowledge gap by working with a team of superb mentors who will supervise the following three training goals: (1) to achieve expertise in clinical research methods and content areas which are critical to her future success as an independent clinician investigator (advanced methods for secondary data analysis, methods for the design, conduct, and analysis of clinical trials, social determinants of health, and qualitative research); (2) to create key developmental networks at UCSF and nationally; and (3) to develop grant-writing and research management skills and experience. Dr. Brown will achieve these goals by conducting the proposed research project with the close guidance and support of her mentorship team. In addition, her training will be supported by high-value didactic courses, tutorials, and seminars. The skills and experience she acquires from this training will prepare her to become an independent investigator and to successfully apply for an R01 grant implementing an intervention to identify and manage premature geriatric syndromes. Dr. Brown's research will describe the epidemiology and risk factors for premature geriatric syndromes (Aim 1), and will identify the relationship between premature geriatric syndromes and adverse outcomes, including hospitalization, institutionalization, and mortality (Aim 2). Dr. Brown will accomplish Aims 1 and 2 using longitudinal data from the nationally representative Health and Retirement Study. She will then conduct a qualitative study to better understand patient and clinician perspectives on the clinical needs of patients with premature geriatric syndromes, and to identify models of care that may help to address those needs (Aim 3).