2014 Intermediate Filaments Gordon Research Conference and Gordon Research Semina

2014年中间长丝戈登研究会议暨戈登研究研讨会

• 批准号: 8718603
• 负责人: KAREN M RIDGE
• 金额: $ 2.25万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-20 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8718603
• 关键词: Academia; Alzheimer' s Disease; Architecture; Area; Arthritis; Attention; Axonal Neuropathy; Biochemical; Biological Models; Biology; Biomedical Research; Bulla; Caenorhabditis elegans; Cardiomyopathies; Categories; Cell Shape; Cells; Clinical; Commit; Databases; Development; Dilated Cardiomyopathy; Discipline; Disease; Drosophila genus; Ensure; Environment; Epidermis; Epithelial; Etiology; Feedback; Fees; Funding; Gastrointestinal Diseases; Gender; Gene Family; Genes; Goals; Health; Human; Human Genome; Immune System Diseases; Immunity; Individual; Industry; Intermediate Filament Gene; Intermediate Filament Proteins; Intermediate Filaments; International; Keratin; Knowledge; Laboratories; Light; Link; Location; Measures; Mentors; Mesenchymal; Metabolic Diseases; Metabolism; Micrometastasis; Minority; Molecular; Motor Neuron Disease; Mus; Muscular Dystrophies; Musculoskeletal Diseases; Mutation; Neurodegenerative Disorders; Nuclear; Physicians; Play; Postdoctoral Fellow; Premature aging syndrome; Problem Solving; Process; Progeria; Proteins; Regulation; Request for Applications; Research; Research Personnel; Resort; Resources; Scientist; Series; Serum; Signal Transduction; Snow; Source; Structural Protein; Structure; Students; Techniques; Tissues; Travel; Trustees; Tumor Markers; Vimentin; Woman; Xenopus; Zebrafish; abstracting; career; career development; developmental genetics; disease phenotype; disease-causing mutation; experience; graduate student; human disease; human tissue; insight; meetings; novel; peer; posters; public health relevance; skin disorder; stem; symposium; tumor

DESCRIPTION (provided by applicant): The human genome contains at least 65 functional genes encoding intermediate filament proteins, placing them among the 100 largest gene families in humans. The remarkable discoveries of hundreds of mutations in IF genes that give rise to a plethora of human diseases have attracted the attention of basic scientists and physicians. The etiology and clinical manifestations of abnormal intermediate filament proteins are wide-ranging, including premature aging diseases such as progeria, cardiomyopathies, neurodegenerative disorders, numerous forms of muscular dystrophy, as well as blistering diseases of the epidermis, amongst many others. In other diseases abnormal aggregates of IF are now being recognized as factors in motor neuron diseases, Alzheimer's disease and giant axonal neuropathy. Furthermore, intermediate filament proteins can serve as markers of the tissue origin of poorly differentiated tumors (keratins define epithelial tissues, whereas vimentin defines mesenchymal origin), as tumor markers in serum, and as a means of detecting micrometastases. The 2014 GRC IF Meeting aims to unite researchers contributing distinct perspectives and experience but who together reveal insights relevant to intermediate filament biology, such as their structural and functional relationships to other established or emerging areas. Our objective is to promote a stimulating series of scientific sessions and an environment attractive to young investigators/ trainees from diverse backgrounds while encouraging established scientists to embark on novel questions. In addition to the use of human tissue and database resources, model systems represented will include Drosophila, Xenopus, zebrafish, C. elegans and mouse. The approaches represented will include molecular/ biochemical, cellular and structural/ biophysical, genetic/ developmental, while discussion will be structured within eight categories indicated below in the session titles. The GRC IF meetings bring together individuals that would not otherwise gather in a similarly intimate scientific forum. Thus, both established investigators and trainees look-forward to this opportunity once every two years. As represented in our speaker/chair list, we have been attentive to gender diversity with a strong representation of outstanding women researchers. We have further made limited progress on the representation of accomplished minority researchers presenting talks. The attendance of young scientists has always been encouraged and in recognition of this, the GRC Board of Trustees has provided resources for a second IF Gordon Research Seminar, which will precede the Conference and will be organized by graduate students and postdoctoral fellows. All applicants are invited to present posters describing their latest research and a number of platform presentations will be chosen from the submitted abstracts in order to ensure inclusion of the latest breakthroughs during the formal sessions.

描述(申请人提供)：人类基因组包含至少65个编码中间丝蛋白的功能基因，使其跻身于人类最大的100个基因家族之列。在导致人类多种疾病的IF基因中发现了数百个突变，这一引人注目的发现引起了基础科学家和医生的注意。中间丝蛋白异常的病因和临床表现多种多样，包括早衰症、心肌病、神经退行性疾病、多种形式的肌营养不良以及表皮水泡性疾病等。在其他疾病中，IF的异常聚集现在被认为是运动神经元疾病、阿尔茨海默病和巨大轴索神经病的因素。此外，中间丝蛋白可以作为低分化肿瘤组织起源的标志(角蛋白定义上皮组织，而波形蛋白 作为血清中的肿瘤标志物，以及作为检测微转移的一种手段。2014年GRC IF会议旨在联合研究人员，他们提出了不同的观点和经验，但他们共同揭示了与中间丝生物学相关的见解，例如他们与其他成熟或新兴领域的结构和功能关系。我们的目标是促进一系列激动人心的科学会议和对来自不同背景的年轻研究人员/受训人员具有吸引力的环境，同时鼓励知名科学家着手提出新的问题。除了使用人体组织和数据库资源外，所代表的模型系统还将包括果蝇、非洲爪哇、斑马鱼、线虫和老鼠。所介绍的方法将包括分子/生化、细胞和结构/生物物理、遗传/发育，而讨论将在下列会议标题中列出的八个类别内进行。GRC IF会议将原本不会聚集在同样亲密的科学论坛上的个人聚集在一起。因此，老牌调查人员和实习生都期待着每两年有一次机会。正如我们的发言者/主席名单所示，我们一直关注性别多样性问题，有一大批杰出的女性研究人员。我们在发言的有成就的少数民族研究人员的代表方面取得了进一步有限的进展。青年科学家的出席一直受到鼓励，为承认这一点，GRC董事会为第二次IF Gordon研究研讨会提供了资源，该研讨会将在会议之前举行，将由研究生和博士后研究员组织。所有申请者都被邀请展示描述他们最新研究的海报，并将从提交的摘要中选择一些平台演示，以确保在正式会议期间纳入最新突破。