3D Printed Nano-Bionic Organs

3D打印纳米仿生器官

• 批准号: 8742786
• 负责人: Michael McAlpine
• 金额: $ 2.04万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8742786
• 关键词: 3D Print; Acoustics; Address; Anatomy; Area; Auditory; Biological; Biology; Bionics; Cartilage; Cells; Cochlea; Development; Devices; Ear; Electrodes; Electronics; Exhibits; Eye; Frequencies; Generations; Geometry; Human; Hydrogels; Impairment; In Vitro; Investigation; Left; Methods; Music; Nose; Organ; Polymers; Printing; Process; Prosthesis; Radio; Regenerative Medicine; Shapes; Silver; System; Tissue Engineering; Tissues; Ultrasonics; User-Computer Interface; Work; biological systems; nano; nanomaterials; nanoparticle; novel; novel strategies; prevent; public health relevance; two-dimensional

DESCRIPTION (provided by applicant): The development of approaches for multidimensional integration of functional electronic components with biological tissue and organs could have tremendous impact in regenerative medicine, smart prosthetics, and human-machine interfaces. However, current electronic devices and systems are inherently two dimensional and rigid, thus prohibiting seamless meshing with three-dimensional, soft biology. The ability to three-dimensionally interweave biological tissue with functional electronics could enable the creation of bionic organs for restoring impairments, or enhancing human functionalities over their natural limitations. Current electronics are inherently two-dimensional, preventing seamless integration with biology, as the processes and materials used to create synthetic tissue constructs vs. conventional electronic devices are very different. Here, we present a novel strategy for overcoming these difficulties via additive manufacturing of biological cells with various classes of functional electronic nanomaterials. Recently, we have generated a functional bionic ear via 3D printing of a cell-seeded hydrogel matrix in the precise anatomic geometry of a human ear, along with an intertwined conducting polymer consisting of infused silver nanoparticles. This allowed for the in vitro culturing of cartilage tissue around an inductive coil antenna in the ear, which subsequently connects to cochlea-shaped electrodes. The printed ear exhibits enhanced auditory sensing for radio frequency reception, and complementary left and right ears can listen to stereo music. Here, we propose extending this approach to new functionalities - such as ultrasonic acoustic reception and vasculature - and bionic organs, including bionic eyes and a bionic nose. Overall, our approach presents a disruptive and paradigm-shifting new method to intricately merge biology and electronics via 3D printing. The work outlined here thus constitutes a novel, highly interdisciplinary investigation to addressing outstanding questions in the generation of bionic organs, and we anticipate that this work will represent a paradigm-shift in both tissue engineering, as well as 3D interweaving of functional electronics into biological systems.

描述（由申请人提供）：开发功能电子组件与生物组织和器官多维整合的方法可能对再生医学，智能假体和人机界面产生巨大影响。然而，当前的电子设备和系统本质上是二维且刚性的，因此禁止使用三维软生物学的无缝网缝。三维与功能电子学的交织生物组织的能力可以使仿生器官恢复障碍或增强人类功能在自然限制上。当前的电子本质上是二维的，可以防止与生物学无缝整合，因为用于创建合成组织构建体与常规电子设备的过程和材料非常不同。在这里，我们提出了一种新的策略，可以通过具有各种功能性电子纳米材料的生物细胞的添加剂制造来克服这些困难。最近，我们通过3D打印了人耳的精确解剖几何形状，以及由注入的银纳米颗粒组成的相互缠绕的导电聚合物，通过3D打印了细胞种子水凝胶基质。这允许在耳朵中的电感线圈天线周围体外培养软骨组织， 随后连接到耳蜗形电极。印刷的耳朵表现出增强的听觉感应，以进行射频接收，互补的左和右耳可以听立体音乐。在这里，我们建议将这种方法扩展到新功能（例如超声声音接受和脉管系统）和仿生器官，包括仿生的眼睛和仿生鼻。总体而言，我们的方法提出了一种破坏性和范式转移的新方法，可以通过3D打印精巧合并生物学和电子产品。因此，这里概述的工作构成了一项新型的高度跨学科的研究，以解决仿生器官的出色问题，我们预计这项工作将代表组织工程中的范式偏移，以及将功能电子学交织到生物学系统中的3D交互。