3D Printed Nano-Bionic Organs

3D打印纳米仿生器官

• 批准号: 9063925
• 负责人: Michael McAlpine
• 金额: $ 226.09万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9063925
• 关键词: 3D; Printed; Nano; Bionic; Organs

DESCRIPTION (provided by applicant): The development of approaches for multidimensional integration of functional electronic components with biological tissue and organs could have tremendous impact in regenerative medicine, smart prosthetics, and human-machine interfaces. However, current electronic devices and systems are inherently two dimensional and rigid, thus prohibiting seamless meshing with three-dimensional, soft biology. The ability to three-dimensionally interweave biological tissue with functional electronics could enable the creation of bionic organs for restoring impairments, or enhancing human functionalities over their natural limitations. Current electronics are inherently two-dimensional, preventing seamless integration with biology, as the processes and materials used to create synthetic tissue constructs vs. conventional electronic devices are very different. Here, we present a novel strategy for overcoming these difficulties via additive manufacturing of biological cells with various classes of functional electronic nanomaterials. Recently, we have generated a functional bionic ear via 3D printing of a cell-seeded hydrogel matrix in the precise anatomic geometry of a human ear, along with an intertwined conducting polymer consisting of infused silver nanoparticles. This allowed for the in vitro culturing of cartilage tissue around an inductive coil antenna in the ear, which subsequently connects to cochlea-shaped electrodes. The printed ear exhibits enhanced auditory sensing for radio frequency reception, and complementary left and right ears can listen to stereo music. Here, we propose extending this approach to new functionalities - such as ultrasonic acoustic reception and vasculature - and bionic organs, including bionic eyes and a bionic nose. Overall, our approach presents a disruptive and paradigm-shifting new method to intricately merge biology and electronics via 3D printing. The work outlined here thus constitutes a novel, highly interdisciplinary investigation to addressing outstanding questions in the generation of bionic organs, and we anticipate that this work will represent a paradigm-shift in both tissue engineering, as well as 3D interweaving of functional electronics into biological systems.

描述（由申请人提供）：功能电子组件与生物组织和器官的多维集成方法的开发可能对再生医学、智能假肢和人机界面产生巨大影响。然而，目前的电子设备和系统本质上是二维和刚性的，因此禁止与三维软生物学无缝啮合。将生物组织与功能性电子器件进行三维交织的能力可以创造出仿生器官，用于修复损伤，或增强人体功能，克服其自然局限性。目前的电子设备本质上是二维的，这阻止了与生物学的无缝集成，因为用于创建合成组织构造的过程和材料与传统电子设备非常不同。在这里，我们提出了一种新的策略，通过用各种功能电子纳米材料增材制造生物细胞来克服这些困难。最近，我们通过在人耳的精确解剖几何结构中3D打印细胞接种的水凝胶基质沿着由注入的银纳米颗粒组成的交织导电聚合物来生成功能性仿生耳。这允许在耳中的感应线圈天线周围体外培养软骨组织， 其随后连接到耳蜗形电极。打印的耳朵表现出增强的无线电频率接收听觉感应，互补的左右耳可以听立体声音乐。在这里，我们建议将这种方法扩展到新的功能-例如超声波接收和脉管系统-以及仿生器官，包括仿生眼睛和仿生鼻子。总的来说，我们的方法提供了一种颠覆性和范式转变的新方法，通过3D打印将生物学和电子学复杂地融合在一起。因此，这里概述的工作构成了一种新颖的，高度跨学科的研究，以解决仿生器官生成中的突出问题，我们预计这项工作将代表组织工程的范式转变，以及功能电子器件到生物系统的3D交织。