Stress, Parenting and Cognitive Function in Children with Sickle Cell Disease

镰状细胞病儿童的压力、养育和认知功能

基本信息

批准号：
8687703
负责人：
Bruce E Compas
金额：
$ 18.41万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8687703
关键词：
Abnormal Hemoglobins Accounting Acute Affect African American Age Anemia Area Attention Biological Birth Order Blood Flow Velocity Blood Vessels Caregivers Cerebrovascular Circulation Cerebrum Characteristics Child Chronic Chronic Disease Code Cognitive Communication Crowding Development Disease Education Enrollment Environmental Risk Factor Failure Family Fathers Gender Genotype Goals Health Health Insurance Hereditary Disease Home environment Household Hypoxia Impaired cognition Impairment Income Infarction Intervention Ischemia Language Lead Life Measures Mediator of activation protein Medical Methodology Methods Modeling Mothers Neurocognitive Nutritional Outcome Parenting behavior Parents Patients Performance Population Poverty Prevalence Process Production Public Health Quality of life Recording of previous events Recruitment Activity Relative (related person)Research Risk Risk Factors Risk Marker Role Sampling Schools Severity of illness Siblings Sickle Cell Sickle Cell Anemia Site Sleep Apnea Syndromes Social Concepts Socioeconomic Status Staging Stress Stroke Testing Underserved Population Work adverse outcome cognitive function executive function experience grandparent indexing male neglect parental role public health relevance social therapy development

项目摘要

DESCRIPTION (provided by applicant): Children with sickle cell disease (SCD) experience significant problems in neurocognitive development, including deficits in overall intellectual functioning and in specific areas such as attention and executive function. A number of disease-related factors have been shown to be predictive of the extent of neurocognitive problems including sickle cell genotype, history of overt stroke/cerebral infarct, history of silent infarct/micro infarcts, chronic hypoxia due to anemia, acute hypoxia, nutritional deficits, increased peak cerebral blood flow velocity, and sleep disordered breathing/sleep apnea. However, social-environmental risk factors that may contribute additional risk for neurocognitive problems in children with SCD have received relatively little attention. The lone exceptions are two studies that have shown that low family socioeconomic status (SES) is related to poorer neurocognitive function in children with SCD. A growing body of research on children growing up in poverty has shown that environmental stress is a significant risk factor for cognitive impairment in children growing up poor and that disrupted/non-responsive parenting is a central mediator of the effects of poverty and stress on children's cognitive function and development. However, no studies to date have examined the potential role of parenting as a contributing factor in neurocognitive impairment in children with SCD. The goal of the proposed research is to test the feasibility, acceptability and initial proof of concept of social-environmental predictrs of cognitive function in children with SCD. We will (a) recruit a wide age range of children with SCD and their parents; (b) recruit a sibling control sample; (c) recruit a sample of healthy contro children from families without chronic illness; (d) administer cognitive tests to children with SCD their parents, and their siblings, as well as healthy control children and their parents; and (e) conduct direct observations of interactions of parents with children with SCD and interactions of parents with sibling controls and healthy controls and their parents.

描述（由申请人提供）：患有镰状细胞疾病（SCD）的儿童在神经认知发展方面遇到了重大问题，包括整体智力功能以及注意力和执行功能等特定领域的缺陷。已经显示出许多与疾病相关的因素可以预测神经认知问题的程度，包括镰状细胞基因型，公开中风/脑梗塞的病史，无声梗塞/微梗塞的病史，贫血引起的慢性缺氧，急性低氧缺陷，营养缺陷，营养峰值，峰值水流兽医和睡眠不适/睡眠不适/睡眠不适。但是，可能导致SCD儿童神经认知问题的额外风险的社会环境风险因素受到相对较少的关注。孤独的例外是两项研究表明，低家庭社会经济地位（SES）与SCD儿童的神经认知功能较差有关。越来越多的关于在贫困中成长的儿童的研究表明，环境压力是成长贫困儿童认知障碍的重要危险因素，而破坏/不反应的育儿是贫困和压力对儿童认知功能和发展的影响的中心调解人。但是，迄今为止，还没有研究育儿作为SCD儿童神经认知障碍的促成因素的潜在作用。拟议的研究的目的是测试SCD儿童认知功能的社会环境概念的可行性，可接受性和初始证明。我们将（a）招募有SCD及其父母的儿童年龄范围广泛；（b）招募同级控制样本；（c）从没有慢性疾病的家庭中招募来自家庭健康的儿童样本；（d）对父母的SCD儿童，兄弟姐妹以及健康对照的孩子及其父母进行认知测试；（e）直接观察父母与儿童具有SCD的互动以及父母具有同级控制和健康对照及其父母的互动。