1/2-Family Cognitive Behavioral Prevention of Depression in Youth and Parents

1/2-青少年和家长抑郁症的家庭认知行为预防

基本信息

批准号：
8812904
负责人：
Bruce E Compas
金额：
$ 37.97万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-03-01 至 2019-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8812904
关键词：
Adopted Adult Affect Age American Anxiety Behavioral Benchmarking Characteristics Child Child Rearing Cognition Cognitive Cognitive Therapy Consensus Coordination and Collaboration Coping Skills Data Demographic Factors Depressed mood Depressive disorder Disease Disruptive Behavior Disorder Doctor of Philosophy Ethnic Origin Evidence based intervention Family Goals Health Healthcare Incidence Individual Institute of Medicine (U.S.)Intervention Mediating Mediator of activation protein Mental Depression Mental Health Mental Health Services Mental disorders Modeling Morbidity - disease rate National Institute of Mental Health National Research Council Nature Outcome Parents Pediatrics Prevalence Prevention Prevention approach Prevention program Preventive Preventive Intervention Process Protocols documentation Psychopathology Public Health Quality-Adjusted Life Years Race Randomized Randomized Controlled Trials Recurrence Relapse Relative (related person)Research Domain Criteria Research Personnel Risk Robin bird Running Sampling Scientist Severities Site Stress Symptoms Techniques Testing Time Universities Work Writing Youth base behavioral study child depression coping cost effective cost effectiveness depression prevention depressive symptoms design disability efficacy testing experience improved functioning innovation intervention effect meetings novel offspring post intervention prevent programs public health priorities sex single episode major depressive disorder skills stressor therapy design

项目摘要

DESCRIPTION (provided by applicant): Depression is a major public health problem affecting over 15 million U.S. adults annually and is especially prevalent in those of parenting age. Offspring of depressed parents are at increased risk of depression and therefore are a critical target for preventive interventions. Informed in part by the investigators' prior work, the field i now poised to make significant advances toward reducing the rate of depression by adopting an innovative, family-based approach to simultaneously preventing depression in at-risk children and in their affected parents. The rationale for this approach is based on (a) our conceptual model that integrates parenting processes, stressors (particularly those associated with parental depression), and children's self-regulatory skills in the face of stress, (b) strong evidence of th familial nature of depression, (c) promising results from family- and child-focused depression prevention programs, (d) evidence that in adults, cognitive-behavioral therapy (CBT) reduces both depressive episodes and their recurrence, and (e) growing consensus among scientists, clinicians, and policymakers on the need for family-based models of healthcare. The proposed 5- year, two-site randomized controlled trial will test a Family Depression Prevention (FDP) program for children (ages 9-15) and their parents with depressive disorders (past or current). This "dual prevention" approach is a novel synthesis of existing evidence-based intervention techniques drawn from child prevention and adult treatment models. Participating families (N=300) will be randomized to either FDP (12 weekly + 3 monthly sessions) or a written information control (WI) condition. Parents and children will be evaluated at pre-, mid-, and immediately post-intervention, and at 6-, 12-, 18-, and 24-months from baseline. This single integrated intervention aims to prevent depressive symptoms and episodes in both children and parents, reduce associated disorders, and improve functioning (Aim 1). We also will assess the cost-effectiveness (CE) of FDP relative to the WI control and benchmarked against the CE of landmark studies in child prevention and adult depression treatment (Aim 1). Additionally, we will examine mediators (e.g., parenting behaviors; parents' cognitions; children's coping) and evaluate bidirectional effects between child and parent processes and outcomes (Aim 2). Finally, we will explore moderators [e.g., parental depression severity (Aim 3)] of the intervention-outcome relation.

描述（由申请人提供）：抑郁症是一个主要的公共卫生问题，每年影响超过1500万美国成年人，并且在育儿年龄尤为普遍。沮丧的父母的后代有抑郁症的风险增加，因此是预防干预措施的关键目标。在调查人员的先前工作中的一部分情况下，我现在准备通过采用一种创新的，基于家庭的方法来同时防止处于危险的孩子及其受影响的父母的抑郁症来降低抑郁症的速度。 The rationale for this approach is based on (a) our conceptual model that integrates parenting processes, stressors (particularly those associated with parental depression), and children's self-regulatory skills in the face of stress, (b) strong evidence of th familial nature of depression, (c) promising results from family- and child-focused depression prevention programs, (d) evidence that in adults, cognitive-behavioral therapy (CBT) reduces both depressive episodes and他们的复发，以及（e）科学家，临床医生和决策者对基于家庭医疗保健模式的需求的日益增长的共识。拟议的5年，两场随机对照试验将针对儿童（9-15岁）及其父母患有抑郁症（过去或现在）的父母测试家庭抑郁症计划（FDP）计划。这种“双重预防”方法是从预防儿童和成人治疗模型中得出的现有基于证据的干预技术的新型综合。参与的家庭（n = 300）将被随机分为FDP（每周12个每月3个会话）或书面信息控制（WI）条件。父母和孩子将在干预前，中期和立即进行评估，并在基线的6个，12、12、18和24个月中进行评估。这种单一的综合干预旨在防止儿童和父母的抑郁症状和发作，减少相关疾病并提高功能（AIM 1）。我们还将评估FDP相对于WI控制的成本效益（CE），并针对预防儿童和成人抑郁症治疗的Landmark研究基准（AIM 1）。此外，我们将检查调解人（例如，育儿行为；父母的认知；孩子的应对），并评估子女过程和父母过程和结果之间的双向效应（AIM 2）。最后，我们将探索主持人[例如，父母的抑郁严重程度（AIM 3）]。