HPV and Cancer mHealth Prevention Education for HIV Positive Women Pilot Study

针对 HIV 阳性女性的 HPV 和癌症 mHealth 预防教育试点研究

• 批准号: 8734349
• 负责人: Lisa Tisdale Wigfall
• 金额: $ 14.23万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-13 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8734349
• 关键词: AIDS/HIV problem; Academic Training; Acquired Immunodeficiency Syndrome; Active Learning; Address; Adherence; African American; Applications Grants; Appointment; Area; Awareness; Behavior; Belief; Cancer Biology; Cancer Burden; Cancer Control; Cancer Control Research; Chronic Disease; Clinic; Clinical; Clinical Immunology; Collaborations; Communication; Communication Research; Communities; Data; Detection; Development; Diagnosis; Diagnostic; Dysplasia; Educational Intervention; Effectiveness; Enabling Factors; Environment; Epidemiology; Extramural Activities; Failure; Funding; Future; Goals; HIV; HIV Seropositivity; HIV/STD; Head and Neck Cancer; Health; Health Communication; Health Promotion and Education; Health Services Research; Health system; High-Risk Cancer; Homelessness; Human Papillomavirus; Human papilloma virus infection; Immune system; Incidence; Individual; International; Intervention; K-Series Research Career Programs; Knowledge; Life; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mediating; Mentors; Mentorship; Modeling; Needs Assessment; Oncogenic; Outcome; Peer Review; Pilot Projects; Population; Predisposing Factor; Prevention; Prevention education; Procedures; Process; Professional counselor; Provider; Publications; Recruitment Activity; Reinforcing Factor; Research; Research Activity; Research Design; Research Personnel; Research Training; Resources; Risk; Risk Reduction; Rural; Safe Sex; Science; Screening for cancer; Services; Shelter facility; Social support; Solutions; South Carolina; Technology; Testing; Training; Training Activity; Underrepresented Minority; Vulnerable Populations; Woman; Women' s Group; Work; anticancer research; base; cancer care; cancer epidemiology; cancer health disparity; cancer prevention; cancer risk; career; career development; cervical cancer prevention; community based participatory research; cost effective; data management; evaluation/testing; experience; follow-up; health belief; health disparity; improved; innovation; mHealth; medically underserved; meetings; mortality; multilevel analysis; peer; post-doctoral training; prevent; professor; programs; public health relevance; research study; screening; skills; social; symposium; therapy development; tool

DESCRIPTION (provided by applicant): The candidate is a research assistant professor with academic training in health promotion, education, and behavior, as well as postdoctoral training in HIV/AIDS prevention, health disparities, and health services research. She also has data management expertise and clinical immunology experience. The candidate has completed two pilot studies that examined HPV infection and cervical cancer prevention knowledge, beliefs and screening behaviors among women living with HIV (WLH). The candidate is seeking additional training needed to develop and implement effective cancer health (including mHealth) communication and community navigation strategies to improve WLH's timely use of cancer screening, diagnostic and treatment services and procedures. The candidate's long-term goal is to obtain extramural research funding for her independent research program focusing on the prevention and control of HPV-mediated cancers among WLH over the next 5-10 years. Promotion to associate professor (tenure- or research-track) is an intermediate goal that the candidate is striving to attain within the next five years. A combination of formal didactic trainig and experiential learning opportunities will be used to acquire cancer prevention and control research skills in the following areas: cancer health (including mHealth) communication, cancer epidemiology, HPV-mediated cancer biology, community navigation, advanced epidemiological research skills (e.g., social epidemiology, n- of-1 research study designs, and, multilevel modeling). The candidate will use the cancer prevention and control research and health communication knowledge and skills acquired through the proposed career development award to conduct formative research needed to inform intervention development in which she will examine cancer health information seeking and sharing among WLH as well as their non-clinical HIV service providers (e.g., HIV/STI risk reduction counselors). Non-clinical HIV service providers will be included because, in addition to the fact that these individuals are already promoting safe sexual practices among WLH, they are also able to reach marginalized groups of WLH such as those who are homeless. This includes sheltered and unsheltered homeless WLH. The candidate's mentors and co-mentors have scientific expertise and community-based participatory research experience that will increase the likelihood of the proposed specific aims being successfully completed. The candidate will first examine HPV-mediated cancer prevention knowledge, beliefs and behaviors, as well as cancer health communication seeking and sharing behaviors (including the use of technology to find health information) (Aim 1). These formative research data will then be used to inform the development (Aim 2) and subsequent pilot testing and evaluation (Aim 3) of an HPV- mediated cancer prevention mHealth education intervention aimed at training WLH who already serve as peer leaders and non-clinical HIV service providers to use mHealth tools and community navigation strategies to disseminate HPV-mediated cancer prevention education. As community navigators, these individuals will use cancer health (including mHealth) communication and community navigation strategies to increase awareness about HPV-mediated cancer risk. This will include promoting cancer risk reducing behaviors such as safe sexual practices and the timely use of recommended cancer screening, diagnostic, and treatment services and procedures). Recall and reminder messages will be sent for screening and follow-up cancer care appointments. User-defined social support messages will also be sent to WLH who may be encountering access to cancer care barriers. The candidate will disseminate the scientific research findings to local, regional, national, and international audiences via presentations that she will give at scientific conferences and annual meetings as well as peer-reviewed publications that she will produce. Most relevant to the candidate's long-term goal of attaining research independence is increasing her number of peer-reviewed publications from her current publication rate of approximately three per year to four or more produced annually by the end of the 5-year training period and the submission of at least one grant proposal (e.g., R01-level funding) by the end of the 5-year training period. The proposed career development/training and research activities will enable the candidate to realize her long-term career goal of becoming an independent cancer researcher with expertise in using cancer health communication, community navigation, and mHealth technologies to address health system failures encountered by vulnerable, medically-underserved WLH along the cancer care continuum. Continued mentoring and opportunities for team science research collaborations will facilitate the candidate's successful progression to being an independent cancer researcher. WLH and non-clinical HIV service providers will be recruited from Ryan White funded clinics and AIDS-service organizations located in urban and rural geographical areas of South Carolina that represent a microcosm of disparities in HIV/AIDS, cancer, and other chronic illness that disproportionately burden medically underserved minority populations. Addressing health system failures that occur along the cancer care continuum that result in missed opportunities to prevent, detect, diagnose and treat HPV-mediated cancers will help to reduce the burden of cancer incidence and mortality among this high cancer risk, vulnerable group of WLH. The proposed HPV-mediated cancer mHealth prevention education intervention will be conducted in a community-based setting and builds upon an existing academic-community partnership between the candidate and a local AIDS-service organization. The candidate has a supportive, resource-intensive scientific environment for her cancer research training.

描述（由申请人提供）：候选人是一名研究助理教授，在健康促进，教育和行为方面接受过学术培训，并在艾滋病毒/艾滋病预防，健康差距和卫生服务研究方面接受过博士后培训。她还拥有数据管理专业知识和临床免疫学经验。候选人已经完成了两项试点研究，研究了艾滋病毒感染妇女（WLH）的HPV感染和宫颈癌预防知识，信念和筛查行为。候选人正在寻求开发和实施有效的癌症健康（包括移动健康）沟通和社区导航策略所需的额外培训，以改善WLH及时使用癌症筛查，诊断和治疗服务和程序。候选人的长期目标是为她的独立研究项目获得校外研究资金，该项目的重点是在未来5-10年内预防和控制WLH中HPV介导的癌症。晋升为副教授（终身制或研究轨道）是候选人在未来五年内努力实现的中间目标。正式的教学培训和体验式学习机会相结合，将用于获得以下领域的癌症预防和控制研究技能：癌症健康（包括mHealth）通信，癌症流行病学，HPV介导的癌症生物学，社区导航，先进的流行病学研究技能（例如，社会流行病学、n-1研究设计和多水平建模）。候选人将利用通过拟议的职业发展奖获得的癌症预防和控制研究以及健康传播知识和技能，进行必要的形成性研究，以告知干预措施的发展，其中她将检查WLH及其非临床HIV服务提供者之间寻求和共享的癌症健康信息（例如，减少艾滋病毒/性传播感染风险顾问）。将包括非临床艾滋病毒服务提供者，因为除了这些人已经在妇女和女童中推广安全的性行为之外，他们还能够接触到妇女和女童的边缘化群体，如无家可归者。这包括有庇护和无庇护的无家可归者。候选人的导师和共同导师具有科学专门知识和基于社区的参与性研究经验，这将增加成功完成拟议具体目标的可能性。候选人将首先检查HPV介导的癌症预防知识，信念和行为，以及癌症健康沟通寻求和分享行为（包括使用技术寻找健康信息）（目标1）。然后，这些形成性研究数据将用于为HPV介导的癌症预防mHealth教育干预措施的开发（目标2）和后续试点测试和评估（目标3）提供信息，该干预措施旨在培训已经担任同行领导者和非临床HIV服务提供者的WLH使用mHealth工具和社区导航策略来传播HPV介导的癌症预防教育。作为社区导航员，这些人将使用癌症健康（包括mHealth）通信和社区导航策略来提高对HPV介导的癌症风险的认识。这将包括促进降低癌症风险的行为，如安全的性行为和及时使用推荐的癌症筛查，诊断和治疗服务和程序。将发送召回和提醒消息，以进行筛查和随访癌症护理预约。用户定义的社会支持信息也将发送给可能遇到癌症护理障碍的WLH。候选人将通过她将在科学会议和年会上发表的演讲以及她将制作的同行评审出版物向当地，区域，国家和国际观众传播科学研究成果。与候选人实现研究独立性的长期目标最相关的是，在5年培训期结束时，将同行评审的出版物数量从目前的每年约3篇增加到每年4篇或更多，并提交至少一份资助申请（例如，R 01级供资）的5年培训期结束时。拟议的职业发展/培训和研究活动将使候选人能够实现她的长期职业目标，成为一名独立的癌症研究人员，拥有使用癌症健康传播，社区导航和移动健康技术的专业知识，以解决弱势，医疗服务不足的WLH沿着癌症护理连续体遇到的卫生系统故障。持续的指导和团队科学研究合作的机会将促进候选人成功发展成为一名独立的癌症研究人员。WLH和非临床HIV服务提供者将从Ryan白色资助的诊所和艾滋病服务组织中招募，这些诊所和艾滋病服务组织位于南卡罗来纳州的城市和农村地理区域，代表了HIV/艾滋病，癌症和其他慢性疾病不成比例地负担医疗服务不足的少数群体的差异的缩影。解决沿着癌症护理连续体发生的卫生系统故障，导致错过预防、检测、诊断和治疗HPV介导的癌症的机会，将有助于减少WLH中这一高癌症风险弱势群体的癌症发病率和死亡率负担。拟议的HPV介导的癌症mHealth预防教育干预将在社区环境中进行，并建立在候选人和当地艾滋病服务组织之间现有的学术社区伙伴关系基础上。候选人有一个支持性的，资源密集型的科学环境，她的癌症研究培训。