Southwest Environmental Health Sciences Center

西南环境健康科学中心

• 批准号: 8650841
• 负责人: Serrine S Lau
• 金额: $ 159.08万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8650841
• 关键词: Address; Area; Biological; Charge; Child; Clinical; Collaborations; Communities; Community Health; Community Health Education; Community Outreach; Complement; Core Facility; Disease; Dust; Educational workshop; Elements; Ensure; Environment; Environmental Exposure; Environmental Health; Exposure to; Faculty; Future; Genomics; Geographic Locations; Goals; Health Sciences; Hispanic Americans; Human; International; Knowledge; Life; Lung diseases; Mentors; Methodology; Mexico; Mission; Multinational Perspectives; National Institute of Environmental Health Sciences; Native Americans; Newsletter; Philosophy; Pilot Projects; Policies; Population; Positioning Attribute; Proteomics; Public Health; Research; Research Personnel; Resources; Risk; Role; Route; Science; Scientist; Sunlight; Sustainable Development; System; Techniques; Technology; Training; Translating; Translations; Uncertainty; Water; base; career development; cellular imaging; community living; disorder prevention; disorder risk; health science research; human disease; human subject; improved; innovation; instrumentation; interdisciplinary collaboration; minority health; programs; research study; response; success

DESCRIPTION (provided by applicant) The mission of the Southwest Environmental Health Sciences Center (SWEHSC) is to understand the mechanisms behind the modulation of human disease risk by environmental exposures. This is essential to the long-term goal of bringing an improvement to the lives of the people of the Southwest by developing rational approaches to mitigating their risks of hazardous environmental exposures and by maximizing their protective environmental exposures. The geographic location of the SWEHSC, with its rich Hispanic and Native American cultural heritage, provides unique opportunities for basic environmental health sciences research to impact the health of these minority populations. Moreover, the strengthening of ties between SWEHSC faculty and academic and governmental agencies in northern Mexico will facilitate the enhancement of bi-national initiatives in the environmental health sciences, with the real ability to improve public health along the U.S./Mexico border. Focusing the investigators' efforts on arid environment, diseases, and people common to the Southwest will allow broad translation to global stakeholders with similar populations and environments. Research at SWEHSC is coordinated within themes. Leaders of each thematic area have been charged with developing interdisciplinary groups aimed at integrating investigators with diverse expertise to produce environmental health deliverables through the incorporation of key elements of the investigators' philosophy for environmental health science, including i) a human/translational focus, ii) defining protective as well as harmful environmental exposures, iii) viewing environmental problems through an international perspective, and iv) utilizing cutting edge technology to enable systems-level biological analysis. The SWEHSC embraces 4 major scientific themes: Southwest Hazardous Environmental Exposure (RFG1), Environmental Lung Diseases (RFG2), ROS and Disease Prevention (RFG3), and Exposure, Fate, and Disposition (RFG4). The research efforts of SWEHSC are complemented by four Facility Cores (FC) offering state-of-the-art instrumentation and expertise to assist investigators in developing and utilizing cutting-edge technologies: Cellular Imaging, Genomics, Proteomics, and Integrative Health Sciences Facility Core. The Administrative Core provides enrichment programs, including seminars, workshops, an annual Science Fair, newsletters, and supports the activities of the Internal and External Advisory Boards. The SWEHSC also promotes innovative research through the Pilot Project Program, and in the recruitment of new investigators. The Career Development Core provides mentoring to junior investigators and cross-training of researchers in current techniques to enhance the environmental health science research programs of fellows and clinicians, and for bench researchers establishing human studies research. The Community Outreach and Education Core (COEC) supports the SWEHSC mission of community involvement by translating and disseminating the research findings of SWEHSC scientists. During the next five years SWEHSC will continue to extend basic environmental health sciences research into the public health and clinical arenas. Such "translational" initiatives are integral to the goals of SWEHSC.

描述（由申请人提供） 西南环境健康科学中心（SWEHSC）的使命是了解环境暴露调节人类疾病风险的机制。这对于通过制定合理的方法来减轻其危险环境暴露的风险并最大限度地提高其保护性环境暴露来改善西南地区人民生活的长期目标至关重要。SWEHSC的地理位置，其丰富的西班牙裔和美洲原住民文化遗产，为基础环境健康科学研究提供了独特的机会，以影响这些少数民族人口的健康。 此外，加强与 SWEHSC教师和学术和政府机构在北方墨西哥将促进在环境健康科学的两国倡议的增强，与真实的能力，以改善公共卫生沿着美国/墨西哥边境。 将研究人员的努力集中在西南地区常见的干旱环境、疾病和人群上，将使具有相似人口和环境的全球利益相关者能够广泛地了解。 SWEHSC的研究在主题范围内进行协调。 每个专题领域的领导人负责发展跨学科小组，旨在整合具有不同专业知识的调查人员，通过纳入调查人员环境健康科学哲学的关键要素，产生环境健康可交付成果，包括i）人类/翻译重点，ii）定义保护性和有害的环境暴露，iii）从国际视角看待环境问题，iv）利用尖端技术进行系统级生物分析。SWEHSC包含4个主要科学主题：西南有害环境暴露（RFG 1），环境性肺部疾病（RFG 2），ROS和疾病预防（RFG 3）和暴露，命运和处置（RFG 4）。 SWEHSC的研究工作得到了四个设施核心（FC）的补充，提供最先进的仪器和专业知识，以协助研究人员开发和利用尖端技术：细胞成像，基因组学，蛋白质组学和综合健康科学设施核心。行政核心提供丰富的方案，包括研讨会，讲习班，年度科学博览会，通讯，并支持内部和外部咨询委员会的活动。 SWEHSC还通过试点项目计划和招募新的研究人员来促进创新研究。职业发展核心为初级研究人员提供指导，并对研究人员进行当前技术的交叉培训，以加强研究员和临床医生的环境健康科学研究计划，并为建立人类研究的板凳研究人员提供指导。社区外展和教育核心（COEC）通过翻译和传播SWEHSC科学家的研究成果，支持SWEHSC的社区参与使命。 在未来五年中，SWEHSC将继续将基础环境卫生科学研究扩展到公共卫生和临床领域。这种“转化”举措是SWEHSC目标的组成部分。