Test of Effects of Social Conflict on Posttraumatic Stress Symptoms and Alcohol A

描述（由申请人提供）：拟议的项目旨在准备P.I.作为一名临床科学家，在学术医疗环境中从事研究计划，重点是开发和评估针对共病酒精使用障碍和创伤后应激障碍（PTSD）的干预措施。因此，拟议的培训计划系统地针对以下方面的培训：1）创伤后应激障碍和酒精使用障碍（AUD），重点是相关的合并症，2）社会功能（重点是社会冲突），3）进行和采用转化研究，为治疗开发提供信息，以及4）治疗评估。这些培训目标旨在通过一级和二级申办者的密集现场指导、重点课程、有针对性的临床活动、非现场培训机会和整个申请过程中描述的传播活动的可行组合来实现。总的来说，这些活动将作为一个重要的跳板， 私家侦探在她追求上述职业目标的过程中， 基于实验室的方法来了解可能的维持机制共同创伤后应激障碍和酒精使用障碍。 拟议的研究项目将加强对上述职业的培训，目标是由P. I。通过对70名至少患有阈下创伤后应激障碍的成年危险饮酒者的社会冲突进行方法学先进的、对照的、基于实验室的研究，提供了宝贵的经验。本研究的主要目的是探讨社会冲突对创伤后应激症状和酒精倾向的影响。创伤后应激症状反应将通过症状的自我报告和面部肌电图测量的反应来测量;酒精接近偏差将通过自我报告的渴望水平和酒精相关的接近回避任务来测量。将受试者随机分配（按受试者性别分层）至中性社交脚本或社交冲突脚本条件。据预测，参与者在社会冲突的条件下，相比那些在中性的社会条件下，将证据更大的创伤后应激症状反应和酒精的方法偏见，响应脚本管理。据进一步预测，这些影响对妇女的影响将大于男子。重要的是，这项研究将解决现有研究中的一个临床显著差距，该研究尚未将社会冲突作为PTSD/危险酒精使用合并症的可能共同维持机制进行研究。 根据研究表明患有PTSD/AUD共病的个体经历了许多特别严重的问题，包括但不限于，与仅被诊断患有上述疾病之一的人相比，生活质量更差，治疗结果更差。因此，拟议的培训和研究计划具有相当大的潜力，最终影响共病PTSD/AUD造成的重大公共卫生负担。

DESCRIPTION (provided by applicant): The proposed project aims to prepare the P.I. for a career as a clinical scientist in an academic medical setting with a program of research focused on the development and evaluation of interventions targeting comorbid alcohol use disorders and posttraumatic stress disorder (PTSD). Accordingly, the proposed training plan systematically targets training in 1) PTSD and alcohol use disorders (AUDs), with an emphasis on related comorbidity, 2) social functioning (with an emphasis on social conflict), 3) conducting and employing translational research to inform treatment development, and 4) treatment evaluation. These training goals were designed to be addressable via the feasible combination of intensive on-site mentoring from a primary and secondary sponsor, focused coursework, targeted clinical activities, off-site training opportunities, and dissemination activities describd throughout the application. Collectively, these activities will serve as a critical springboard for the P.I. in her pursuit of the above-stated career goal by yielding training in the use of advanced laboratory-based methods to understand possible maintaining mechanisms common to both PTSD and alcohol use disorders. The proposed research project will enhance training for the above-stated career targeted by the P.I. by providing valuable experience in the administration of a methodologically-advanced, controlled, laboratory- based study of social conflict among 70 adult hazardous drinkers with at least subthreshold PTSD. The primary aim of the study is to investigate the effects of social conflict on both state posttraumatic stress symptoms and alcohol approach bias. Posttraumatic stress symptom reactions will be measured via self-report of symptoms and facial electromyography-measured responses; alcohol approach bias will be measured via self-reported craving levels and the alcohol-related Approach-Avoidance Task. Participants will be randomly assigned (stratified by participant sex) to either a neutral social script or a social conflict script condition. It is predicted that participants in the social conflct condition, compared to those in the neutral social condition, will evidence greater posttraumatic stress symptom reactions and alcohol approach bias in response to script administration. It is further predicted that these effects will be greater for women than men. Importantly, this study will address a clinically significant gap in existing research, which has not examined social conflict as a possible common maintaining mechanism in PTSD/hazardous alcohol use comorbidity. The proposed project is demonstrably significant in light of research suggesting individuals with comorbid PTSD/AUD experience many particularly severe problems, including but not limited to, poorer quality of life and worse treatment outcomes compared to those who are diagnosed with only one of the aforementioned disorders. Accordingly, the proposed program of training and research has considerable potential to ultimately impact the significant public health burden posed by comorbid PTSD/AUDs.