A CBT-Based Text Messaging Intervention for Methamphetamine Dependence

基于 CBT 的甲基苯丙胺依赖短信干预

• 批准号: 8650807
• 负责人: GANTT P GALLOWAY
• 金额: $ 8.21万
• 依托单位: CALIFORNIA PACIFIC MED CTR RES INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8650807
• 关键词: Accidents; Accounting; Adoption; Alcohols; American; Back; Behavior Therapy; Burn injury; Cellular Phone; Characteristics; Clinic; Clinical Trials; Cognitive Therapy; Complement; Cross-Over Studies; Data; Dental caries; Dependence; Development; Effectiveness; Enrollment; Feasibility Studies; Focus Groups; Frequencies; Group Interviews; Group Therapy; Health Care Costs; Health education; Healthcare; Hour; Individual; Intervention; Interview; Length of Stay; Methamphetamine; Methamphetamine dependence; Methods; Online Systems; Outcome; Outpatients; Patient Self-Report; Patients; Pharmaceutical Preparations; Phase; Plant Leaves; Preparation; Procedures; Process; Public Health; Randomized; Relapse; Research; Risk; Sampling; Services; Staging; Support Groups; System; Technology; Testing; Text; Time; Treatment Efficacy; Treatment outcome; Urine; Work; active control; assault; base; cost; craving; design; drinking; improved; innovation; member; novel; pilot trial; preference; psychosocial; public health relevance; scale up; smoking cessation; therapy development; tool; treatment center

DESCRIPTION (provided by applicant): This application proposes to improve treatment outcomes for methamphetamine- (MA-) dependent subjects through development of an innovative cognitive behavioral therapy- (CBT-) based text messaging intervention. While CBT reduces MA use, it and other psychosocial therapies have limited effectiveness, and patients treated for MA dependence have a high rate of relapse. Thus, a significant need exists for add-on therapy for treatment of MA dependence. We are using an iterative process to develop and refine this intervention. We have convened an expert panel, conducted three focus groups with MA-dependent subjects, interviewed 25 subjects being treated for MA dependence, and conducted a five-subject feasibility trial. We will reconvene the expert panel to review our candidate text messages and study methods. Active and control text messages will be uploaded into a web-based application that we have developed for this purpose. We will conduct a pre-test in which 10 subjects receive two weeks of the active text messages and two weeks of control text messages; these conditions will be in random, counterbalanced order with a one-week washout. Messages will be "pushed" to subjects four times per day and can also be "pulled" on an as-requested basis. Subjects will attend one-hour CBT-based group therapy sessions three times per week. We will collect urine samples for toxicological analyses, self-reports of MA use, craving scores, and ratings of the utility and acceptability of the intervention Qualitative interviews after subjects complete each condition will assess the perceived utility of the approach, preferences for message content, and acceptability. When all subjects have completed, we will hold a focus group and reconvene the expert panel. After making any indicated revisions to the text messages or procedures, we will implement a second crossover trial with 40 subjects, conduct another focus group with subjects who were in the second trial, reconvene the expert panel again, and select text messages to be used in a subsequent large randomized parallel group trial. This will be an inexpensive intervention to deploy that utilizes technology that is affordable and widely available - basic cellular telephones. The low-intensity, high-frequency, and always available characteristics of this intervention contrast to conventional outpatient treatment and may be a valuable complement to it. It will be readily extensible, both to MA users who cannot attend formal treatment, and also to individuals dependent on other drugs.

描述（由申请人提供）：本申请建议通过开发创新的认知行为疗法（CBT-）基于基于的文本消息传递干预措施来改善甲基苯丙胺（MA-）依赖受试者的治疗结果。尽管CBT降低了MA的使用，但IT和其他社会心理疗法的有效性有限，而接受MA依赖的患者的复发率很高。因此，对接种疗法的治疗有很大的需求。 我们正在使用迭代过程来开发和完善这种干预措施。我们召集了一个专家小组，进行了三个具有MA依赖受试者的焦点小组，采访了25名接受MA依赖的受试者，并进行了五项受试者的可行性试验。 我们将重新调整专家小组以审查我们的候选文本消息和研究方法。主动和控制文本消息将被上传到我们为此目的开发的基于Web的应用程序中。我们将进行预测试，其中10名受试者接收两周的主动短信和两周的控制短信；这些条件将以一周的冲洗方式随机，平衡的顺序。消息将每天将消息“推”到主题四次，也可以按要求“拉”。受试者每周三次参加基于CBT的小组治疗课程一小时。我们将收集用于毒理学分析，MA使用的自我报告，渴望得分的自我报告以及效用的评级和干预定性访谈的评级和可接受性，后者在每个受试者完成每个条件后都将评估方法的感知实用性，对消息内容的偏好和可接受性。当所有受试者完成后，我们将举行一个焦点小组并重新召集专家小组。在对文本消息或程序进行了任何指示的修订后，我们将与40名受试者实施第二次交叉试验，并与第二次试验的受试者进行另一个焦点小组，再次重新调整专家小组，然后选择在随后的大型随机随机平行组试验中使用的文本消息。 这将是一种廉价的干预措施，用于部署利用负担得起且广泛可用的技术 - 基本的蜂窝电话。这种干预措施的低强度，高频和始终可用的特征与常规门诊治疗形成鲜明对比，并且可能是有价值的补充。对于不能参加正式治疗的MA用户以及依赖其他药物的个人，这将很容易扩展。