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A CBT-Based Text Messaging Intervention for Methamphetamine Dependence

基于 CBT 的甲基苯丙胺依赖短信干预

基本信息

批准号：
9261629
负责人：
GANTT P GALLOWAY
金额：
$ 8.16万
依托单位：
FRIENDS RESEARCH INSTITUTE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-15 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9261629
关键词：
CBT Based Text Messaging Intervention

项目摘要

DESCRIPTION (provided by applicant): This application proposes to improve treatment outcomes for methamphetamine- (MA-) dependent subjects through development of an innovative cognitive behavioral therapy- (CBT-) based text messaging intervention. While CBT reduces MA use, it and other psychosocial therapies have limited effectiveness, and patients treated for MA dependence have a high rate of relapse. Thus, a significant need exists for add-on therapy for treatment of MA dependence. We are using an iterative process to develop and refine this intervention. We have convened an expert panel, conducted three focus groups with MA-dependent subjects, interviewed 25 subjects being treated for MA dependence, and conducted a five-subject feasibility trial. We will reconvene the expert panel to review our candidate text messages and study methods. Active and control text messages will be uploaded into a web-based application that we have developed for this purpose. We will conduct a pre-test in which 10 subjects receive two weeks of the active text messages and two weeks of control text messages; these conditions will be in random, counterbalanced order with a one-week washout. Messages will be "pushed" to subjects four times per day and can also be "pulled" on an as-requested basis. Subjects will attend one-hour CBT-based group therapy sessions three times per week. We will collect urine samples for toxicological analyses, self-reports of MA use, craving scores, and ratings of the utility and acceptability of the intervention Qualitative interviews after subjects complete each condition will assess the perceived utility of the approach, preferences for message content, and acceptability. When all subjects have completed, we will hold a focus group and reconvene the expert panel. After making any indicated revisions to the text messages or procedures, we will implement a second crossover trial with 40 subjects, conduct another focus group with subjects who were in the second trial, reconvene the expert panel again, and select text messages to be used in a subsequent large randomized parallel group trial. This will be an inexpensive intervention to deploy that utilizes technology that is affordable and widely available - basic cellular telephones. The low-intensity, high-frequency, and always available characteristics of this intervention contrast to conventional outpatient treatment and may be a valuable complement to it. It will be readily extensible, both to MA users who cannot attend formal treatment, and also to individuals dependent on other drugs.

描述（由申请人提供）：本申请旨在通过开发一种创新的基于认知行为疗法（CBT）的短信干预来改善甲基苯丙胺（MA-）依赖受试者的治疗效果。虽然CBT减少了MA的使用，但它和其他社会心理疗法的效果有限，并且治疗MA依赖的患者复发率很高。因此，对于MA依赖的附加治疗存在着重要的需求。我们正在使用一个迭代过程来开发和完善这种干预措施。我们召集了一个专家小组，对MA依赖的受试者进行了三个焦点小组，采访了25名正在接受MA依赖治疗的受试者，并进行了一项五人可行性试验。我们将重新召集专家小组审查我们的候选短信和学习方法。活动和控制文本消息将被上传到我们为此目的开发的基于web的应用程序中。我们将进行一个预测试，其中10名受试者收到两周的主动短信和两周的对照短信；这些条件将以随机、平衡的顺序进行，并进行为期一周的冲洗。消息每天将被“推送”四次，也可以根据需要“拉出”。受试者将参加每周一次、每次一小时的基于cbt的团体治疗。我们将收集尿液样本进行毒理学分析、MA使用的自我报告、渴望得分以及干预的效用和可接受性评级。在受试者完成每个条件后，定性访谈将评估该方法的感知效用、对信息内容的偏好和可接受性。当所有主题完成后，我们将举行焦点小组讨论，并重新召集专家小组。在对短信或程序进行任何指定的修改后，我们将对40名受试者进行第二次交叉试验，与参加第二次试验的受试者进行另一次焦点小组讨论，再次召集专家小组，并选择短信用于随后的大型随机平行组试验。这将是一种廉价的干预措施，它利用的是负担得起的和广泛可用的技术——基本的移动电话。与传统的门诊治疗相比，这种干预具有低强度、高频率和随时可用的特点，可能是一种有价值的补充。它将很容易扩展，既适用于不能参加正式治疗的MA使用者，也适用于依赖其他药物的个人。