Health Sciences Center Animal Resource Facility Improvement

描述(由申请人提供)：这项题为“UNM健康科学中心动物资源设施改善”的G20提案的目的是申请499,967美元：1)支持购买25个带笼子/附件的通风鼠架和相关的机械和电气结构，以在五个SPF鼠室中的四个(第五个房间位于老鼠繁殖屏障中，连接在最近的翻修期间安装)中的四个(1261 GSF/1159 NSF)中，将这些装置与建筑排气和电气设备连接起来。2)升级SPF小鼠研究套件中的2个程序室(399 GSF/352 NSF)，以移除旧的和增加新的案例，并购买一个5英尺的HEPA过滤动物程序站，位于其中一个程序室。受该项目影响的总空间为1,660 GSF/1,511 NSF，其中包括新墨西哥大学(UNM)健康科学中心(HSC)动物资源设施(ARF)设备放置和/或翻新的空间。该ARF项目位于生物医学研究设施(BRF)和基础医学大楼(BMSB)内的连续空间。BRF/BMSB动物设施是ARF的主要组成部分，但HSC ARF还包括两个HSC卫星成像设施的住房/研究。该项目是在2002年、2008年和2013年在BRF和BMSB ARF完成的前三个翻修项目的基础上进行改进的。这些过去的翻修升级了机械(带有DDC控制和环境警报的暖通空调)、地板、饰面和屋顶，最近的项目(2012年G20奖励50万美元外加8.2万美元的机构比赛)更换了一台已有26年历史的隧道洗涤器，翻新了4个房间，并在老鼠饲养障碍的4个房间中的3个房间增加了16个通风老鼠架。这一新的拟议项目将在小鼠养殖屏障(屏障支持19个PI实验室)的剩余空间中增加5个通风鼠架，这些空间将与大笼子(180英寸2个/笼-36个笼/架)一起购买，这些大笼子可以通过互换小笼子(75英寸2个/笼)(2个小笼子可以容纳1个大笼子)在繁育障碍的任何机架上使用。我们建议在繁殖障碍中设置大笼子，以支持第8版NIH指南中推荐的每只繁殖雌性有足够的空间进行三种繁殖。其次，我们建议在无特定病原体(SPF)研究套件的4个小鼠房间中翻新和增加20个通风支架(5个支架/房间)。这些拟议的通风机架是单面单元，每个单元可容纳72个笼子(75英寸2个笼子)。这种机架形式将使我们的房间笼子容量增加25%(288到360个笼子)。这一SPF小鼠研究套件目前支持41个PI实验室。这些房间目前已经接近饱和，3名新的拥有老鼠研究项目的教职员工计划在2014年1月之前将他们的老鼠转移到ARF。三名教员中有两名是癌症中心的成员，我们的目标是将他们与其他老鼠癌症研究用户放在一起。该项目将增加该套件的容量，以支持这一目标。SPF小鼠研究室的两个程序室目前有中央氧气和吸入异氟醚麻醉单元，通过我们的建筑排气提供废麻醉气体清除。其中一个房间有一个II A2类生物安全柜，为小鼠提供保护，使其免受潜在的微生物污染和操作员安全(仅限颗粒物)。其中一个房间的橱柜是木制的，两个房间的橱柜的数量和格式都不足以支持我们这间套房的用户。因此，我们建议升级两个程序室的个案工作，以改善隔离安全设备储存的功能，在其中一个程序室增加一个带有个案工作的新水槽，并增加一个流动高效空气过滤器程序站。总体而言，该项目是从静态微型隔离鼠笼向通风笼子过渡的延续。该项目的完成对于我们继续实现我们的战略和计划目标至关重要，这些目标是：扩大NIH和UNM HSC之间富有成效的合作伙伴关系；加强我们对HSC标志性项目(脑和行为疾病、癌症、心血管和代谢疾病、儿童健康、环境健康、传染病和免疫)的支持；扩大与ARF的新的协同发展，将其作为我们的临床和翻译科学中心奖(CTSC)的技术核心之一；提高动物护理合规性；以及维持HSC自1973年以来一直持续的AAALAC认证。该项目下的新设备将改善动物饲养室和笼子的空气质量，使笼子和建筑物排出的废气通风，并通过节约能源和水(减少更换笼子/卫生设施的频繁次数)加强新墨西哥州大学的可持续发展目标。劳动力和笼子用品的成本也将降低，这将降低核心用户的成本上升。总之，我们不断寻求通过我们的跨学科CTSC加快发现步伐的方法，该中心的总体目标是促进更健康的公共医疗和更负担得起的患者护理。

DESCRIPTION (provided by applicant): The aim of this G20 proposal entitled "UNM Health Sciences Center Animal Resource Facility Improvement" is a request for $499,967 to: 1) support purchase of 25 ventilated mouse racks with cages/accessories and associated mechanical and electrical construction to provide connection of these units to building exhaust and electrical in four of the five SPF mouse rooms (the 5th room is in the mouse breeding barrier and connections were installed during a recent renovation) (1261 gsf / 1159 nsf). 2) To upgrade 2 procedures rooms (399 gsf / 352 nsf) in the SPF mouse research suite to remove old and add new casework and purchase a 5 foot HEPA filtered animal procedure station to be located in one of the procedure rooms. The total space affected by this project is 1,660 gsf / 1,511 nsf, and it includes space where equipment is sited and/or renovation at the University of New Mexico (UNM) Health Sciences Center (HSC) Animal Resource Facility (ARF). This ARF project is located in contiguous space within the Biomedical Research Facility (BRF) and the Basic Medical Sciences Building (BMSB). The BRF/BMSB animal facilities comprise the major component of ARF but the HSC ARF also includes housing/research in two HSC satellite imaging facilities. This project builds upon improvements from three previous renovation projects completed in the BRF and BMSB ARF in 2002 and 2008, and 2013. These past renovations upgraded mechanical (HVAC with DDC controls and environmental alarms), floors, finishes and roofing and the most recent project (2012 G20 award $500K plus $82K institutional match) replaced a 26 year old tunnel washer, renovated 4 rooms and added 16 ventilated mouse racks to 3 of the 4 rooms in the mouse breeding barrier. This new proposed project will add five ventilated mouse racks to the remaining room in the mouse breeding barrier (barrier supports 19 PI laboratories) that will be purchased with the large cages (180 in2/cage - 36 cages/rack) that can be used in any rack in the breeding barrier by interchanging with small cages (75 in2/cage) (2 small cages fit in the slot for 1 large cage). We propose the large cages in the breeding barrier to allow us to support trio breeding with adequate space per breeding female recommended under the 8th edition NIH guide. Second we propose to renovate and add 20 ventilated racks (5 racks/room) in the 4 mouse rooms in the specific pathogen free (SPF) research suite. These proposed ventilated racks are single sided units with capacity of 72 cages (75 in2 /cage) per unit. This rack format will allow us to increase room cage capacity by 25% (288 to 360 cages). This SPF mouse research suite currently supports 41 PI laboratories. These rooms are currently near capacity and 3 new faculty with mouse research programs plan to transfer their mice to the ARF by January 2014. Two of the 3 faculty are members of the Cancer Center and our goal is to co-locate them with the rest of our mouse cancer research users. This project will increase capacity in this suite to support this goal. The two procedure rooms in the SPF mouse research suite currently have central oxygen gases and inhalant isoflurane anesthesia units with waste anesthetic gas scavenging provided through our building exhaust. One of the rooms has a Class II A2 Biosafety Cabinet that provides protection to the mice from potential microbiological contamination and operator safety (particulate only). The casework in one of the rooms is wooden and the quantity and format of the casework in both rooms is insufficient to support our users in this suite. Therefore, we propose to upgrade casework in the two procedure rooms to improve functionality with segregated secure equipment storage, add a new sink with the casework in one of the procedure rooms and add a mobile HEPA filter procedure station. In general, this project is a continuation to transition from static microisolatr mouse cages to ventilated cages. Completion of the project is critical for us to continue meeting our strategic and programmatic goals which are to: expand a productive partnership between the NIH and UNM HSC; enhance our support to the HSC Signature Programs (Brain and Behavioral Illnesses, Cancer, Cardiovascular and Metabolic Disease, Child Health, Environmental He0alth, and Infectious Diseases and Immunity); expand development of new emerging synergies with ARF as one of the technology cores within our Clinical and Translational Science Center Award (CTSC); improve animal care compliance; and sustain AAALAC accreditation which HSC has continued since 1973. New equipment under this project will improve animal care by improving animal room and cage air quality with ventilation of the cages and exhaust from the building and enhance UNM'S sustainability goals by saving energy and water (less frequent cage changing/sanitation). The cost of labor and cage supplies will also be reduced which will lower cost escalation to core users. In conclusion, we continually seek ways to accelerate the pace of discoveries through our interdisciplinary CTSC which has overarching goals to promote a healthier public and more affordable patient care.