Health Sciences Center Animal Resource Facility Improvement

健康科学中心动物资源设施改善

• 批准号: 8712910
• 负责人: Kevin C O'Hair
• 金额: $ 49.1万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8712910
• 关键词: Accreditation; Affect; Air; Anesthesia procedures; Anesthetic Gases; Animals; Area; Award; Behavioral; Behavioral Research; Biomedical Research; Boxing; Brain; Breeding; Cancer Center; Cardiovascular Diseases; Censuses; Center for Translational Science Activities; Child health care; Clinical; Clinical Sciences; Communicable Diseases; Community Health Centers; Development; Duct (organ) structure; Environmental Health; Environmental air flow; Equipment; Excision; Faculty; Female; Floor; Gases; Goals; Health Sciences; House mice; Housing; Image; Immunity; Immunology; Individual; Inhalant dose form; Isoflurane; Laboratories; Malignant Neoplasms; Mechanics; Medical; Metabolic Diseases; Metabolism; Mus; Neurosciences; New Mexico; Obesity; Oxygen; Particulate; Patient Care; Pharmacy facility; Procedures; Request for Proposals; Research; Research Design; Research Personnel; Rest; Safety; Sanitation; Science; Secure; Side; Site; Specific Pathogen Frees; Stainless Steel; Technology; United States National Institutes of Health; Universities; Water; animal care; animal facility; animal resource; anticancer research; balance testing; college; cost; exhaust; falls; foot; germ free condition; high efficiency particulate air filter; improved; medical schools; meetings; member; mouse model; programs; research facility; wasting

DESCRIPTION (provided by applicant): The aim of this G20 proposal entitled "UNM Health Sciences Center Animal Resource Facility Improvement" is a request for $499,967 to: 1) support purchase of 25 ventilated mouse racks with cages/accessories and associated mechanical and electrical construction to provide connection of these units to building exhaust and electrical in four of the five SPF mouse rooms (the 5th room is in the mouse breeding barrier and connections were installed during a recent renovation) (1261 gsf / 1159 nsf). 2) To upgrade 2 procedures rooms (399 gsf / 352 nsf) in the SPF mouse research suite to remove old and add new casework and purchase a 5 foot HEPA filtered animal procedure station to be located in one of the procedure rooms. The total space affected by this project is 1,660 gsf / 1,511 nsf, and it includes space where equipment is sited and/or renovation at the University of New Mexico (UNM) Health Sciences Center (HSC) Animal Resource Facility (ARF). This ARF project is located in contiguous space within the Biomedical Research Facility (BRF) and the Basic Medical Sciences Building (BMSB). The BRF/BMSB animal facilities comprise the major component of ARF but the HSC ARF also includes housing/research in two HSC satellite imaging facilities. This project builds upon improvements from three previous renovation projects completed in the BRF and BMSB ARF in 2002 and 2008, and 2013. These past renovations upgraded mechanical (HVAC with DDC controls and environmental alarms), floors, finishes and roofing and the most recent project (2012 G20 award $500K plus $82K institutional match) replaced a 26 year old tunnel washer, renovated 4 rooms and added 16 ventilated mouse racks to 3 of the 4 rooms in the mouse breeding barrier. This new proposed project will add five ventilated mouse racks to the remaining room in the mouse breeding barrier (barrier supports 19 PI laboratories) that will be purchased with the large cages (180 in2/cage - 36 cages/rack) that can be used in any rack in the breeding barrier by interchanging with small cages (75 in2/cage) (2 small cages fit in the slot for 1 large cage). We propose the large cages in the breeding barrier to allow us to support trio breeding with adequate space per breeding female recommended under the 8th edition NIH guide. Second we propose to renovate and add 20 ventilated racks (5 racks/room) in the 4 mouse rooms in the specific pathogen free (SPF) research suite. These proposed ventilated racks are single sided units with capacity of 72 cages (75 in2 /cage) per unit. This rack format will allow us to increase room cage capacity by 25% (288 to 360 cages). This SPF mouse research suite currently supports 41 PI laboratories. These rooms are currently near capacity and 3 new faculty with mouse research programs plan to transfer their mice to the ARF by January 2014. Two of the 3 faculty are members of the Cancer Center and our goal is to co-locate them with the rest of our mouse cancer research users. This project will increase capacity in this suite to support this goal. The two procedure rooms in the SPF mouse research suite currently have central oxygen gases and inhalant isoflurane anesthesia units with waste anesthetic gas scavenging provided through our building exhaust. One of the rooms has a Class II A2 Biosafety Cabinet that provides protection to the mice from potential microbiological contamination and operator safety (particulate only). The casework in one of the rooms is wooden and the quantity and format of the casework in both rooms is insufficient to support our users in this suite. Therefore, we propose to upgrade casework in the two procedure rooms to improve functionality with segregated secure equipment storage, add a new sink with the casework in one of the procedure rooms and add a mobile HEPA filter procedure station. In general, this project is a continuation to transition from static microisolatr mouse cages to ventilated cages. Completion of the project is critical for us to continue meeting our strategic and programmatic goals which are to: expand a productive partnership between the NIH and UNM HSC; enhance our support to the HSC Signature Programs (Brain and Behavioral Illnesses, Cancer, Cardiovascular and Metabolic Disease, Child Health, Environmental He0alth, and Infectious Diseases and Immunity); expand development of new emerging synergies with ARF as one of the technology cores within our Clinical and Translational Science Center Award (CTSC); improve animal care compliance; and sustain AAALAC accreditation which HSC has continued since 1973. New equipment under this project will improve animal care by improving animal room and cage air quality with ventilation of the cages and exhaust from the building and enhance UNM'S sustainability goals by saving energy and water (less frequent cage changing/sanitation). The cost of labor and cage supplies will also be reduced which will lower cost escalation to core users. In conclusion, we continually seek ways to accelerate the pace of discoveries through our interdisciplinary CTSC which has overarching goals to promote a healthier public and more affordable patient care.

描述（由申请人提供）：这项题为“UNM健康科学中心动物资源设施改善”的G20提案的目的是要求提供499，967美元，用于：1）资助购置25个通风鼠架连鼠笼/配件，以及相关的机械和电气结构，以便在5个SPF鼠房中的4个，把这些装置接驳至大厦的排气系统和电力系统（第5个房间位于老鼠繁殖屏障内，在最近的装修中安装了连接装置）（1261 gsf / 1159 nsf）。2)升级SPF小鼠研究室中的2个手术室（399 gsf / 352 nsf），以删除旧的并添加新的病例，并购买一个5英尺HEPA过滤动物手术站，位于其中一个手术室中。受本项目影响的总空间为1，660 gsf /1，511 nsf，其中包括新墨西哥州大学（UNM）健康科学中心（HSC）动物资源设施（ARF）的设备放置和/或翻新空间。该ARF项目位于生物医学研究设施（BRF）和基础医学科学大楼（BMSB）内的连续空间。BRF/BMSB动物设施是ARF的主要组成部分，但HSC ARF还包括在两个HSC卫星成像设施中的住房/研究。该项目是在2002年、2008年和2013年在BRF和BMSB ARF完成的三个翻新项目的基础上进行改进的。这些过去的翻修升级了机械（带有DDC控制和环境警报的HVAC），地板，饰面和屋顶，最近的项目（2012年G20奖50万美元加上8.2万美元的机构匹配）取代了26年的隧道洗衣机，翻新了4个房间，并在老鼠繁殖屏障的4个房间中的3个房间增加了16个通风鼠标架。该新拟定项目将在小鼠饲养屏障（屏障支持19个PI实验室）的剩余房间中增加5个通风小鼠机架，这些小鼠机架将与大笼（180 in 2/笼- 36笼/机架）一起购买，通过与小笼（75 in 2/笼）（2个小笼适合1个大笼的插槽）互换，可用于饲养屏障中的任何机架。我们建议在繁殖屏障中使用大笼子，以使我们能够支持第8版NIH指南推荐的每个繁殖雌性有足够空间的三人繁殖。其次，我们建议在无特定病原体（SPF）研究室的4个小鼠室中翻新并增加20个通风机架（5个机架/室）。这些拟议的通风机架为单面装置，每个装置的容量为72个笼（75 in 2/笼）。这种机架格式将使我们能够将房间笼容量增加25%（288至360个笼）。该SPF小鼠研究套件目前支持41个PI实验室。这些房间目前已接近容量，3名新的小鼠研究项目教师计划在2014年1月前将他们的小鼠转移到ARF。三名教师中有两名是癌症中心的成员，我们的目标是将他们与我们的其他小鼠癌症研究用户共同定位。该项目将增加该套件的容量，以支持这一目标。SPF小鼠研究室的两个手术室目前有中央氧气和吸入异氟烷麻醉装置，通过我们的建筑排气装置提供麻醉废气清除。其中一个房间配有II级A2生物安全柜，可保护小鼠免受潜在微生物污染和操作员安全（仅颗粒）。其中一个房间的橱柜是木制的，两个房间的橱柜的数量和格式不足以支持我们在这个套房的用户。因此，我们建议升级两个手术室的病例，以通过隔离的安全设备存储来改善功能，在其中一个手术室增加一个新的水槽，并增加一个移动的HEPA过滤器手术站。总的来说，本项目是从静态微隔离鼠笼向通风鼠笼过渡的延续。该项目的完成对于我们继续实现我们的战略和计划目标至关重要，这些目标是：扩大NIH和UNM HSC之间富有成效的伙伴关系;加强我们对HSC签名计划的支持（脑和行为疾病，癌症，心血管和代谢疾病，儿童健康，环境健康，传染病和免疫）;扩大与ARF的新兴协同效应的发展，作为我们临床和转化科学中心奖（CTSC）的技术核心之一;提高动物护理合规性;并维持HSC自1973年以来一直持续的AAALAC认证。该项目下的新设备将通过改善动物房和笼子的空气质量，通过笼子的通风和建筑物的排气来改善动物护理，并通过节省能源和水（减少笼子更换/卫生）来提高UNM的可持续发展目标。劳动力和笼具供应的成本也将降低，这将降低核心用户的成本上升。总之，我们不断寻求方法，通过我们的跨学科CTSC加快发现的步伐，其总体目标是促进更健康的公众和更负担得起的患者护理。