Novel molecular and cellular approaches for alcoholism medication development
酒精中毒药物开发的新分子和细胞方法
基本信息
- 批准号:8663140
- 负责人:
- 金额:$ 66.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-05-04 至 2017-04-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAlcohol consumptionAlcohol dependenceAlcoholismAlcoholsAnimal ModelAnimalsBehaviorBindingBrainCollaborationsDNADNA MethylationDataDevelopmentDrug AddictionElectrophysiology (science)Enzyme Inhibitor DrugsEnzyme InhibitorsEpigenetic ProcessEthanolFundingGene ExpressionGene Expression ProfileGenesGenetic TranscriptionGlycine ReceptorsGoalsHistone AcetylationHistone DeacetylationHumanIon ChannelKnowledgeLigandsMeasuresMicroRNAsMolecularMolecular BiologyMolecular TargetMusNeurobiologyPeptidesPhage DisplayPharmaceutical PreparationsProgram Research Project GrantsProteinsRegulator GenesResearchResearch PersonnelResearch Project GrantsScientistSiteTechniquesTechnologyTestingTherapeuticTranslatingTranslationsalcohol researchalcohol rewardalcoholism therapybehavior testdesigndrug developmentexperienceinhibitor/antagonistinnovationmembernew therapeutic targetnovelproblem drinkerprogramstherapy development
项目摘要
This five-year funding proposal for a Program Project Grant on alcohol-related research provides innovative paradigms for medication development for the treatment of alcoholism by bringing together experienced alcohol researchers with expertise in molecular biology, electrophysiology and behavior. The goal is to develop the technologies and collaborations necessary to define new targets for medication development and translate our knowledge of alcohol targets into selective ligands. The PPG consists of an Administrative Core (Adron Harris, PI and Center Director), identification and characterization of specific allosteric modulators of ion channels using phage display (S. John Mihic and Rick Morrisett), molecular and cellular mechanisms of novel therapeutic targets in alcohol reward (Igor Ponomarev and Hitoshi Morikawa), microRNA targets for medication development (Dayne Mayfield) and an animal core (Yuri Blednov and Rueben Gonzales) to provide mice and behavioral testing to the projects. The PPG has both internal and external advisory board members, providing expert guidance from scientists with a wide range of expertise in drug development and therapeutics.
这项为期五年的酒精相关研究项目资助计划的资金提案通过将具有分子生物学、电生理学和行为学专业知识的经验丰富的酒精研究人员聚集在一起,为治疗酒精中毒的药物开发提供了创新的范例。我们的目标是开发必要的技术和合作,以定义药物开发的新靶点,并将我们对酒精靶标的知识转化为选择性配体。PPG包括一个管理核心(Adron Harris、Pi和中心主任),使用噬菌体展示鉴定和表征离子通道的特定变构调节剂(S.John Mihic和Rick Morrisett),酒精奖励新治疗靶点的分子和细胞机制(Igor Ponomarev和Hitoshi Morikawa),用于药物开发的microRNA靶标(Dayne Mayfield),以及为项目提供小鼠和行为测试的动物核心(Yuri Blednov和Rueben Gonzales)。PPG有内部和外部顾问委员会成员,提供来自在药物开发和治疗方面具有广泛专业知识的科学家的专家指导。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert A Harris其他文献
Robert A Harris的其他文献
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{{ truncateString('Robert A Harris', 18)}}的其他基金
Integrative Neuroscience Initiative on Alcoholism
关于酗酒的综合神经科学倡议
- 批准号:
9242459 - 财政年份:2017
- 资助金额:
$ 66.43万 - 项目类别:
Novel molecular and cellular approaches for alcoholism medication development
酒精中毒药物开发的新分子和细胞方法
- 批准号:
8198072 - 财政年份:2012
- 资助金额:
$ 66.43万 - 项目类别:
Novel molecular and cellular approaches for alcoholism medication development
酒精中毒药物开发的新分子和细胞方法
- 批准号:
8465776 - 财政年份:2012
- 资助金额:
$ 66.43万 - 项目类别:
Novel molecular and cellular approaches for alcoholism medication development
酒精中毒药物开发的新分子和细胞方法
- 批准号:
8843309 - 财政年份:2012
- 资助金额:
$ 66.43万 - 项目类别:
Medication Development for Treatment of Alcoholism
治疗酒精中毒的药物开发
- 批准号:
7944098 - 财政年份:2009
- 资助金额:
$ 66.43万 - 项目类别:
Medication Development for Treatment of Alcoholism
治疗酒精中毒的药物开发
- 批准号:
7547590 - 财政年份:2009
- 资助金额:
$ 66.43万 - 项目类别:
Predoctoral Training in Interdisciplinary Neuroscience
跨学科神经科学博士前培训
- 批准号:
6750516 - 财政年份:2004
- 资助金额:
$ 66.43万 - 项目类别:
INHALED AMESTHETICS: MOLECULAR ACTIONS ON ION CHANNELS
吸入美容剂:离子通道上的分子作用
- 批准号:
6807222 - 财政年份:2004
- 资助金额:
$ 66.43万 - 项目类别:
Predoctoral Training in Interdisciplinary Neuroscience
跨学科神经科学博士前培训
- 批准号:
6942305 - 财政年份:2004
- 资助金额:
$ 66.43万 - 项目类别:
Predoctoral Training in Interdisciplinary Neuroscience
跨学科神经科学博士前培训
- 批准号:
7485645 - 财政年份:2004
- 资助金额:
$ 66.43万 - 项目类别:
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