Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety Disorders

焦虑症统一跨诊断治疗的疗效评估

• 批准号: 8589008
• 负责人: David H. Barlow
• 金额: $ 58.1万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-24 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8589008
• 关键词: Acute; Address; Aftercare; Anxiety; Anxiety Disorders; Behavior; Benchmarking; Categories; Chronic; Comorbidity; Country; DSM-IV; Data; Depressive disorder; Diagnosis; Diagnostic; Disease; Emotional disorder; Epidemiologic Studies; Etiology; Individual; Knowledge; Lead; Light; Mediating; Mediator of activation protein; Mental disorders; Nature; Neurotic Disorders; Outcome; Outcome Measure; Patients; Pattern; Pharmacological Treatment; Phase; Prevalence; Procedures; Process; Protocols documentation; Public Health; Quality of life; Regulation; Relative (related person); Robin bird; Sampling; Selective Serotonin Reuptake Inhibitor; Severities; Specific qualifier value; Structure; Surveys; Symptoms; Time; Training; Treatment Efficacy; Treatment Protocols; Treatment outcome; Waiting Lists; active method; base; cost effective; efficacy evaluation; evidence base; follow-up; improved; indexing; innovation; novel; psychologic; public health relevance; treatment effect; treatment response; treatment strategy

DESCRIPTION (provided by applicant): Anxiety disorders are common, chronic, costly, debilitating to quality of life, and are more prevalent than any other class of disorders in every country in the world where surveys have been taken. Deepening understanding of the nature of anxiety and related emotional disorders during the last decade has revealed that commonalities in etiology and latent structure among these disorders supersedes differences. At the same time, examination of extant single diagnosis psychological treatment protocols (SDPs) for these disorders underscores mechanistic similarities. These findings suggested the possibility of distilling a set of psychological procedures that would comprise an innovative Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), and this protocol has now been developed. If efficacious, the UP may represent a more efficient and possibly more effective strategy which would render treatment implications of comorbidity, not otherwise specified (NOS) and subdefinitional threshold anxiety disorder conditions moot. We now propose an evaluation of the efficacy of the UP in a group of patients with heterogeneous anxiety disorders by way of rigorous comparisons to existing evidence based SDPs benchmarked against a wait list control condition, using both statistical equivalence and superiority analyses. Additional aims include determining the durability of the UP relative to comparison conditions after treatment discontinuation, and ascertaining the differential impact of treatments on disorder specific symptoms vs. higher-order temperamental variables. Further analyses will indicate if changes in these higher order temperamental variables mediate long-term outcome as preliminary data suggests, and if this mechanism of action differs among treatments.

描述（由申请人提供）：焦虑症是常见的，慢性的，昂贵的，削弱生活质量，并且比世界上每个国家进行调查的任何其他类型的疾病都更普遍。在过去的十年中，对焦虑和相关情绪障碍的性质的深入了解揭示了这些障碍之间在病因学和潜在结构上的共性取代了差异。与此同时，现存的单一诊断心理治疗方案（SDP）的检查，这些疾病强调机制的相似性。这些研究结果表明，有可能提炼出一套心理程序，包括一个创新的统一协议，用于情绪障碍的跨诊断治疗（UP），这个协议现在已经开发出来。如果有效，UP可能是一种更有效的策略，可能更有效，这将使合并症，未另行说明（NOS）和亚定义阈值焦虑障碍条件的治疗意义无实际意义。我们现在提出了一个评估的有效性的UP在一组异质性焦虑症患者的严格比较现有的证据为基础的SDP基准对等待列表控制条件，使用统计等效性和优越性分析。其他目的包括确定治疗中止后UP相对于比较条件的持久性，并确定治疗对疾病特异性症状与高阶气质变量的差异影响。进一步的分析将表明这些高阶气质变量的变化是否如初步数据所示介导长期结果，以及这种作用机制是否在治疗中存在差异。